Results 51 to 60 of about 18,183 (205)

Seed-produced anti-globulin VHH-Fc antibodies retrieve globulin precursors in the insoluble fraction and modulate the Arabidopsis thaliana seed subcellular morphology [PDF]

, 2020
Key message Nanobody-heavy chain (VHH-Fc) antibody formats have the potential to immunomodulate even highly accumulating proteins and provide a valuable tool to experimentally modulate the subcellular distribution of seed storage proteins.
Altmann, Friedrich, Arcalis, Elsa, De Meyer, Thomas, Depicker, Anna, Maleux, Katrien, Melnik, Stanislav, Nolf, Jonah, Stöger, Eva   +7 more
core   +2 more sources

In Preparation for Outdoor Pharming: Griffithsin Can Be Expressed in Nicotiana excelsiana and Retains Activity After Storage as Silage

Frontiers in Bioengineering and Biotechnology, 2020
Griffithsin is an algae-derived lectin with strong anti-viral activity against HIV and a positive safety profile. Multiple clinical studies are investigating griffithsin's utility as topical HIV microbicide.
Paul Eapen, Jennifer Cates, Rich Mundell, Kenneth E. Palmer, Kenneth E. Palmer, Joshua L. Fuqua, Joshua L. Fuqua   +6 more
doaj   +1 more source

Herbimycin B, a new benzoquinonoid ansamycin with anti-TMV and herbicidal activities.

The Journal of Antibiotics, 1980
A new benzoquinonoid ansamycin, herbimycin B was isolated from the culture broth of Streptomyces hygroscopicus No. AM-3672, a herbimycin A-producing strain. Herbimycin B showed potent anti-TMV activity. Herbicidal effect of herbimycin B was less than that of herbimycin A.
Y, Iwai, A, Nakagawa, N, Sadakane, S, Omura, H, Oiwa, S, Matsumoto, M, Takahashi, T, Ikai, Y, Ochiai   +8 more
openaire   +3 more sources

Potato mop-top virus co-opts the stress sensor HIPP26 for long-distance movement [PDF]

, 2018
The work of LT, GC, SJ and AR is funded by the Scottish Government’s Rural and Environmental Science and Analytical Services (RESAS) Division, PH by the BBSRC (grant BB/M024911/1) and The Royal Society and EIS by the Swedish Research Council Formas and ...
Cowan, Graham H., Gil, Jose F., Hemsley, Piers, Jones, Susan, Kalyandurg, Pruthvi B., Kumar, Pankaj, Roberts, Alison G., Savenkov, Eugene I, Torrance, Lesley   +8 more
core   +4 more sources

Synthesis of tetrazole containing 1,2,3-thiadiazole derivatives via U-4CR and their anti-TMV activity [PDF]

Chinese Chemical Letters, 2013
Abstract A series of novel tetrazole containing 1,2,3-thiadiazole derivatives were designed and synthesized via Ugi reaction. Their structures were confirmed by melting points, IR, 1H NMR, and HRMS (ESI). Preliminary bioassay indicated that most target compounds exhibited very good direct anti-TMV activity at 100 μg/mL, which was equal to or higher ...
Wang, S.-X., Fang, Z., Fan, Z.-J., Wang, D., Li, Y.-D., Ji, X.-T., Hua, X.-W., Huang, Y., Kalinina, T. A., Bakulev, V. A., Morzherin, Y. Y.   +10 more
openaire   +2 more sources

Differential Gene Expression in Response to Papayaringspot virus Infection in Cucumis metuliferus UsingcDNA- Amplified Fragment Length PolymorphismAnalysis [PDF]

, 2013
A better understanding of virus resistance mechanisms can offer more effective strategies to control virus diseases. Papayaringspot virus (PRSV), Potyviridae, causes severe economical losses in papaya and cucurbit production worldwide.
Chia-Wei Lin, Chien-Hung Chung, Fuh-Jyh Jan, Hsin-Mei Ku, Jo-Chu Chen, Shy-Dong Yeh, Yu-Tsung Lin   +6 more
core   +5 more sources

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Two new Anti-TMV active chalconoid analogues from the root of Phyllanthus emblica

Natural Product Research, 2017
Two new chalconoid analogues, emblirol A (1) and B (2), along with three known ones (3–5), were isolated from the root of the Phyllanthus emblica L. Their structures were elucidated on the basis of spectral data. Compound 1 and 2 showed moderate anti-TMV activity with inhibition rates 79.6 and 62.1% at a concentration of 1 mg/mL, respectively.
He, Yan, Li Rong, Han, Xing, Zhang, Jun Tao, Feng   +3 more
openaire   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Genetic modification of alternative respiration in Nicotiana benthamiana affects basal and salicylic acid-induced resistance to potato virus X. [PDF]

, 2011
BACKGROUND: Salicylic acid (SA) regulates multiple anti-viral mechanisms, including mechanism(s) that may be negatively regulated by the mitochondrial enzyme, alternative oxidase (AOX), the sole component of the alternative respiratory pathway.
Carr, John P, Fu, Shih-Feng, Lee, Wing-Sham, Verchot-Lubicz, Jeanmarie   +3 more
core   +2 more sources