Results 41 to 50 of about 2,675,396 (301)

Tuberculosis after anti-TNF therapy [PDF]

Clinical Rheumatology, 2009
Dear Editor We read with interest the recent article by Elbek et al. [1] assessing the risk of tuberculosis in patients treated with anti-TNF therapy. The study reported that tuberculin test positivity in the area of their study was quite frequent (77.9%) and that males more frequently had positive tests.
Pamuk, Omer Nuri, Donmez, Salim
openaire   +2 more sources

Assessment of Anti-TNF-α Activities in Keratinocytes Expressing Inducible TNF- α: A Novel Tool for Anti-TNF-α Drug Screening. [PDF]

PLoS ONE, 2016
Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine important in normal and pathological biological processes. Newly synthesized pro-TNF-α is expressed on the plasma membrane and cleaved to release soluble TNF-α protein: both are ...
Sutthirat Udommethaporn, Tewin Tencomnao, Eileen M McGowan, Viroj Boonyaratanakornkit   +3 more
doaj   +1 more source

Disease progression and protection by anti-TNF-α Ab treatment.

, 2023
(A) IFN-α/β/γR knockout (KO) mice (8–10 weeks old) were infected intraperitoneally with 2 × 106 focus-forming units (FFU) of DENV-3 P12/08 and sacrificed at Days 2, 3, and 4 post-infection (p.i.).
Mohamad Al Kadi (11987393), Masayuki Shimojima (241787), Shuetsu Fukushi (542663), Yasusi Ami (17357710), Tadaki Suzuki (251922), Tomoki Yoshikawa (367816), Hideki Ebihara (18294), Masayuki Saijo (324701), Supranee Phanthanawiboon (2159206), Yusuke Sakai (437974), Noriyo Nagata (389752), Daisuke Kamimura (435268), Masaaki Murakami (2677831), Takeshi Kurosu (538717), Daisuke Okuzaki (482418)   +14 more
core   +1 more source

Hepatitis b reactivation rate in patients using anti tnf theraphy: Evaluation of patients not received anti viral prophylaxis

The Turkish Journal of Gastroenterology, 2019
INTRODUCTION: Hepatitis B virus reactivation (HBVR) is an important condition that can be seen under immunosuppressive therapy. HBVR characterized by necroinflammation of the liver and viral replication and may complicated with in liver failure and death.
Süleyman Sayar, Kemal Kürbüz, Çağatay Ak, Nermin Mutlu Bilgiç, Resul Kahraman, Hakan Demirdağ, Roni Atalay, Zuhal Çalışkan, Oğuzhan Öztürk, Hamdi Levent Doğanay, Kamil Özdil   +10 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Atividade anti-inflamatória do ácido arjunóli-co extraído de Combretum leprosum Mart. & Eicher (Combretaceae) em camundongos [PDF]

, 2011
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.Combretum leprosum (mofumbo ou cipoaba) é um arbusto nativo do Brasil utilizado na medicina popular para o tratamento de hemorragias, como sedativo ...
Cabrera, Celeste Heisecke
core  

Anti-TNF-α Drugs Differently Affect the TNFα-sTNFR System and Monocyte Subsets in Patients with Psoriasis. [PDF]

PLoS ONE, 2016
TNF-α has a central role in the development and maintenance of psoriatic plaques, and its serum levels correlate with disease activity. Anti-TNF-α drugs are, however, ineffective in a relevant percentage of patients for reasons that are currently unknown.
Lara Gibellini, Sara De Biasi, Elena Bianchini, Regina Bartolomeo, Antonella Fabiano, Marco Manfredini, Federica Ferrari, Giuseppe Albertini, Tommaso Trenti, Milena Nasi, Marcello Pinti, Anna Iannone, Carlo Salvarani, Andrea Cossarizza, Giovanni Pellacani   +14 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Indications, response, and side effects of biologic treatment in Behçet’s disease: an 8-year study with follow-up

Rheumatology
Introduction The treatment of Behçet’s disease has improved significantly with the introduction of biologic therapies. However, there is still a need for more information about their use.
Saeedeh Shenavandeh, Elham Aflaki, Maryam Rasti RastiJahromi, Afshin Borhani Haghighi, Mohammad Ali Nazarinia   +4 more
doaj   +1 more source