Results 51 to 60 of about 2,675,396 (301)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Methotrexate Enhances Apoptosis of Transmembrane TNF-Expressing Cells Treated With Anti-TNF Agents

Frontiers in Immunology, 2020
BackgroundConcomitant use of methotrexate (MTX) improves the clinical efficacy of anti-TNF agents in the treatment of rheumatoid arthritis (RA). We aimed to clarify the cytotoxic effect of MTX on transmembrane TNF (tmTNF)-expressing cells treated with ...
Qiaolei Wang, Qiaolei Wang, Daisuke Oryoji, Hiroki Mitoma, Yasutaka Kimoto, Masamichi Koyanagi, Kana Yokoyama, Masahiro Ayano, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Koichi Akashi, Takahiko Horiuchi   +12 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Schematic diagram showing the possible mechanism of anti-TNF-α therapy in polycystic ovary syndrome (PCOS).

, 2019
Persistent exposure to androgen promoted the secretion of TNF-α and other inflammatory factors. TNF-αsignificantly upregulated CYP17A1 and downregulated CYP19A1, the key enzymes involved in the synthesis and conversion of androgens, leading to the ...
Xie Yidong (6807866), Xu Wenming (652821), Zuo Tao (6807875), Zhang Xueguang (6807869), Qin Lang (2902367), Wu Sixian (6807872)   +5 more
core   +1 more source

A Case with Anti TNF- α Induced Bullous Pemhigoid

The Turkish Journal of Gastroenterology, 2010
Tumor necrosis factor-alpha (TNF-α) plays a crucial role in the development of autoimmune diseases, and anti-TNF-α agents are used in the treatment of this group of diseases.
Özlem Altındağ, Ali Aydeniz, Savaş Gürsoy   +2 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Anti-TNF therapy in inflammatory bowel disease: addressing barriers to long-term therapy

, 2022
Anti-TNF agents represent important therapeutics in Crohn’s disease and ulcerative colitis; however, there are barriers to their long-term use. First, anti-TNF agents represent a major driver of healthcare expenditure, highlighting the need to consider ...
Ashish Srinivasan (9209930)
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Response to combination therapy with interferon alfa-2a and ribavirin in chronic hepatitis C according to a TNF-alpha promoter polymorphism [PDF]

, 2003
Background. Tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of chronic active hepatitis C. Polymorphisms in the promoter region of the TNF-alpha gene can alter the TNF-alpha expression and modify the host immune response.
Konig, A., Folwaczny, Christian, Schmidt, F., Simperl, C., Schaefer, M., Torok, P., Glas, J., Schiemann, Uwe, Martin, K.   +8 more
core   +1 more source

Recommendations of the Turkish Society for Rheumatology on tuberculosis screening and treatment in patients receiving advanced antirheumatic drug therapy

Ulusal Romatoloji Dergisi
Tuberculosis (TB) remains a significant public health concern in endemic countries despite widespread Bacillus Calmette-Guérin vaccination. In rheumatology practice, biologic and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs ...
Cemal Bes, Rabia Deniz, Mustafa Ekici, Ufuk İlgen, Burak İnce, Zehra Özsoy, Şerife Çoşkun Sağırkaya, Mehmet Soy, Veli Yazısız, Şükran Erten, Timuçin Kaşifoğlu, İhsan Ertenli   +11 more
doaj   +1 more source