Results 31 to 40 of about 4,564,900 (257)

Interactions between rheumatoid arthritis antibodies are associated with the response to anti-tumor necrosis factor therapy

BMC Musculoskeletal Disorders, 2021
Background Blocking of the Tumor Necrosis Factor (TNF) activity is a successful therapeutic approach for 50–60% of rheumatoid arthritis (RA) patients. However, there are yet no biomarkers to stratify patients for anti-TNF therapy.
Antonio Julià, María López-Lasanta, Francisco Blanco, Antonio Gómez, Isabel Haro, Antonio Juan Mas, Alba Erra, Ma Luz García Vivar, Jordi Monfort, Simón Sánchez-Fernández, Isidoro González, Mercedes Alperi, Raúl Castellanos-Moreira, Antonio Fernández-Nebro, César Díaz-Torné, Núria Palau, Raquel Lastra, Jordi Lladós, Raimon Sanmartí, Sara Marsal   +19 more
doaj   +1 more source

The immunogenicity to the first anti-TNF therapy determines the outcome of switching to a second anti-TNF therapy in spondyloarthritis patients [PDF]

, 2013
Introduction: Anti-TNF drugs have proven to be effective against spondyloarthritis (SpA), although 30% of patients fail to respond or experience adverse events leading to treatment discontinuation.
Emilio Martín-Mola, Alejandro Balsa, Peiteado, Diana, Arribas, Florencia, Maria Teresa López-Casla, Sara García-Carazo, Alejandro Villalba, Nuño, Laura, Laura Nuño, García-Carazo, Sara, Jesus Díez, Florencia Arribas, Lojo, Leticia, Diana Peiteado, Dora Pascual-Salcedo, Balsa Criado, Alejandro, Martìn-Mola, Emilio, Díez, Jesús L., Chamaida Plasencia, Leticia Lojo, Villalba, Alejandro, Plasencia, Chamaida, Pascual-Salcedo, Dora, López-Casla, María Teresa   +23 more
core   +1 more source

Differences in reactivation of tuberculosis induced from anti-TNF treatments are based on bioavailability in granulomatous tissue. [PDF]

PLoS Computational Biology, 2007
The immune response to Mycobacterium tuberculosis (Mtb) infection is complex. Experimental evidence has revealed that tumor necrosis factor (TNF) plays a major role in host defense against Mtb in both active and latent phases of infection.
Simeone Marino, Dhruv Sud, Hillarie Plessner, Philana Ling Lin, John Chan, JoAnne L Flynn, Denise E Kirschner   +6 more
doaj   +1 more source

The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation [PDF]

, 2005
Therapies directed against tumour necrosis factor (TNF) are effective for the treatment of rheumatoid arthritis and reduce pain scores in this condition.
Inglis, JJ, Lees, DM, Ahuva Nissim, Nissim, A, Bruce L Kidd, Kidd, BL, Julia J Inglis, Delphine M Lees, Hunt, SP, Chernajovsky, Y, Stephen P Hunt, Yuti Chernajovsky   +11 more
core   +1 more source

Vaccination status of patients using anti-TNF therapy and the physicians' behavior shaping the phenomenon: Mixed-methods approach.

PLoS ONE, 2019
ObjectiveAnti-tumor necrosis factor (Anti-TNF) therapy improves the prognosis and reduces the morbidity and mortality associated with many chronic inflammatory autoimmune diseases.
Hussain Abdulrahman Al-Omar, Hadeel Magdy Sherif, Ahmed Yaccob Mayet   +2 more
doaj   +1 more source

Single-cell transcriptomic analysis in two patients with rare systemic autoinflammatory diseases treated with anti-TNF therapy

Frontiers in Immunology, 2023
Systemic autoinflammatory diseases (SAIDs) are a group of rare diseases characterized by recurrent or continuous inflammation, typically accompanied by genetic variants. Good responses to anti-TNF therapy were observed in SAIDs patients.
Yichao Hua, Na Wu, Junke Miao, Min Shen
doaj   +1 more source

TNF-alpha in asthma

, 2007
Although only 5-10% of patients with asthma are relatively unresponsive to treatment with inhaled corticosteroids, refractory asthma represents an important condition as these patients suffer considerable morbidity and mortality and consume a ...
Ian D. Pavord (7582361), Andrew J. Wardlaw (7582364), Mike A. Berry (7582358), Christopher E. Brightling (7165121)   +3 more
core   +5 more sources

Anti-TNF therapy [PDF]

, 2016
Tumor necrosis factor (TNF) is one of the most important cytokines produced by macrophages. TNF is a very important component of host defense, released very rapidly after all types of injuries and stimuli.
Nanchahal, J, Jagdeep Nanchahal, Udalova, I, Claudia Monaco, Feldmann, M, Marc Feldmann, Irina Udalova, Nanchahal, Jagdeep, Monaco, C   +8 more
core   +1 more source

Manifestation of palmoplantar pustulosis during or after infliximab therapy for plaque-type psoriasis : report on five cases [PDF]

, 2008
Infliximab is a monoclonal antibody directed against TNF-alpha. It has been approved for use in rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriatic arthritis and plaque-type psoriasis.
Krüger, Ullrich, Thaçi, Diamant, Pätzold, Sylvie, Reich, Kristian, Bertsch, Hans Peter, Mössner, Rotraut, Mohr, Johannes   +6 more
core   +1 more source

Real world analysis on the efficacy and safety of anti-tumor necrosis factor therapy in patients with stricturing Crohn’s disease

Scientific Reports, 2021
Crohn’s disease (CD) is often complicated by strictures and associated with increased risk for surgery. Inflammatory strictures respond to medical therapy, and anti-tumor necrosis factor (TNF) therapy is often used after the failure of steroids. However,
Sudheer K. Vuyyuru, Bhaskar Kante, Peeyush Kumar, Pabitra Sahu, Saurabh Kedia, Mukesh Kumar Ranjan, Raju Sharma, Rajesh Panwar, Govind Makharia, Vineet Ahuja   +9 more
doaj   +1 more source