Results 91 to 100 of about 561,822 (204)
Molecular Microbiology, Volume 121, Issue 6, Page 1112-1126, June 2024.TbTim15 is a new subunit of the non‐canonical trypanosomal inner membrane protein translocase. Abstract All mitochondria import >95% of their proteins from the cytosol. This process is mediated by protein translocases in the mitochondrial membranes, whose subunits are generally highly conserved.
Corinne von Känel +6 more
wiley +1 more source
Anais da Academia Brasileira de Ciências, 2013 The present investigation was to evaluate the potential trypanocidal activity of crude ethanolic extract of the fruits of Solanum palinacanthum, Solanum lycocarpum and the glycoalcaloid, solamargine. S. palinacanthum and S.
RAQUEL R.D. MOREIRA +6 more
doaj +1 more source
Activity in vivo of anti-Trypanosoma cruzi compounds selected from a high throughput screening. [PDF]
PLoS Neglected Tropical Diseases, 2011 Novel technologies that include recombinant pathogens and rapid detection methods are contributing to the development of drugs for neglected diseases.
Grasiella Andriani +4 more
doaj +1 more source
Synthesis, leishmanicidal, trypanocidal and cytotoxic activities of quinoline-chalcone and quinoline-chromone hybrids [PDF]
, 2017 We report herein the synthesis and biological activities (cytotoxicity, leishmanicidal and trypanocidal) of six quinoline-chalcone and five quinoline-chromone hybrids.
Elisa García +8 more
core +2 more sources
, 2018 Azadirachta indica commonly known as Neem is known to possess high medicinal value. This study aimed at determining the in vivo anti trypanosomal potential of aqueous extracts of A. indica leaves on Trypanosoma brucei brucei infected mice.
Okoh Martina Enyanwu +2 more
semanticscholar +1 more source
Medicinal Research Reviews, Volume 44, Issue 3, Page 1055-1120, May 2024.Abstract Leishmaniasis is a group of neglected tropical diseases caused by at least 20 species of Leishmania protozoa, which are spread by the bite of infected sandflies. There are three main forms of the disease: cutaneous leishmaniasis (CL, the most common), visceral leishmaniasis (VL, also known as kala‐azar, the most serious), and mucocutaneous ...
Miguel Marín +4 more
wiley +1 more source
Molecules, 2017 Chagas, or American trypanosomiasis, remains an important public health problem in developing countries. In the last decade, trans-sialidase has become a pharmacological target for new anti-Chagas drugs.
Muhammad Kashif +9 more
doaj +1 more source
The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice [PDF]
, 2010 The activity of the antineoplastic drug tamoxifen was evaluated against Trypanosoma cruzi. In vitro activity was determined against epimastigote, trypomastigote and amastigote forms of CL14, Y and Y benznidazole resistant T. cruzi strains.
ALVES, Rosana de Oliveira +6 more
core +3 more sources
European Journal of Medicinal Chemistry Reports, 2022 Beta-carboline is an indole alkaloid which has been identified as a valuable heterocyclic nucleus in the field of medicinal chemistry. It has different biological activities like antibacterial, anticancer, antifungal, antimalarial, antileishmanial, anti ...
Mahender Thatikayala +6 more
doaj
Inhibition of Bacterial RNase P RNA by Phenothiazine Derivatives
Biomolecules, 2016 There is a need to identify novel scaffolds and targets to develop new antibiotics. Methylene blue is a phenothiazine derivative, and it has been shown to possess anti-malarial and anti-trypanosomal activities.
Shiying Wu +2 more
doaj +1 more source