Results 91 to 100 of about 581,138 (251)

Graphene quantum dots induce cascadic apoptosis via interaction with proteins associated with anti-oxidation after endocytosis by Trypanosoma brucei

Frontiers in Immunology, 2022
Trypanosoma brucei, the pathogen causing African sleeping sickness (trypanosomiasis) in humans, causes debilitating diseases in many regions of the world, but mainly in African countries with tropical and subtropical climates.
Yiwei Xie, Yiwei Xie, Yiwei Xie, Hongrui Liang, Hongrui Liang, Hongrui Liang, Ning Jiang, Ning Jiang, Ning Jiang, Dingyuan Liu, Dingyuan Liu, Dingyuan Liu, Naiwen Zhang, Naiwen Zhang, Naiwen Zhang, Qilong Li, Qilong Li, Qilong Li, Kai Zhang, Kai Zhang, Kai Zhang, Xiaoyu Sang, Xiaoyu Sang, Xiaoyu Sang, Ying Feng, Ying Feng, Ying Feng, Ran Chen, Ran Chen, Ran Chen, Yiwei Zhang, Yiwei Zhang, Yiwei Zhang, Qijun Chen, Qijun Chen, Qijun Chen   +35 more
doaj   +1 more source

Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs. [PDF]

, 2012
Nitroheterocyclic prodrugs are used to treat infections caused by Trypanosoma cruzi and Trypanosoma brucei. A key component in selectivity involves a specific activation step mediated by a protein homologous with type I nitroreductases, enzymes found ...
Alsford, Alsford, Armstrong, Begleiter, Belinda S. Hall, Bern, Bienen, Bot, Brun, Bryant, Chaudhuri, Chen, Clarkson, Danson, Danson, Emma Louise Meredith, Ernster, Faeder, Fang, Fang, Fang, Fang, Garavaglia, Gascon, Goodwin, Guerra, Hall, Hall, Hall, Henderson, Hirumi, Hoet, Hu, Iyanagi, Jaiswal, Jarrom, Koder, Kubata, Müller, Nillius, Nivinskas, Nixon, O'Brien, Pal, Parkinson, Peterson, Pinto, Powis, Purkayastha, Race, Race, Ramos, Rassi, Shane R. Wilkinson, Stein, Stuart, Surve, Tatsumi, Tedeschi, Torri, Torri, Urech, Ward, Watanabe, Whiteway, Wilkinson, Yan, Zenno, Zenno   +68 more
core   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Anti-trypanosomal Potential of Methanolic Extract of Calotropis gigantea Leaves against Trypanosma evansi and its Cytotoxicity

International Journal of Bio-Resource and Stress Management, 2023
In an attempt to find anti-trypanosomal extract/compound(s) from medicinal plant for the treatment of trypanosomosis, Calotropis gigantea leaves were extracted with methanol. The obtained extract was screened at concentrations (250-1000 μg ml-1) against 
P. Shaba, N. N. Pandey, O. P. Sharma, J. R. Rao, R. K. Singh   +4 more
doaj  

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, Volume 32, Issue 5, Page 1747-1760, October 2025.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source

DNA minor groove binders-inspired by nature [PDF]

, 2016
The synthesis and biological activity of a variety of analogues to the naturally occurring anti-bacterial and anti-fungal Distamycin A were explored by a number of authors. These compounds were subject to a large array of assays.
Al-Khadhimi, Ahmed A. H, Ali, Jaafar H., Khalaf, Abedawn I.   +2 more
core   +2 more sources

In-vitro and In-vivo Evaluation of Anti-trypanosomal Activity of Carica papaya Seed Extracts and Fractions in Albino Wister Rats

, 2020
Aims: This study presents baseline data on the In-vitro and In-vivo evaluation of anti-trypanosomal activity of Carica papaya seed extracts and fractions in Albino Wister rats. Study Design: Mention the design of the study here.
H. Kinjir, M. A. Madusolumuo, S. Sarkiyayi   +2 more
semanticscholar   +1 more source

Potential Therapeutic Actions of Flavonoids Present in Propolis That Modulate Vascular Endothelial Growth Factor Signaling to Regulate Angiogenesis

Phytotherapy Research, Volume 39, Issue 9, Page 4230-4246, September 2025.
ABSTRACT Propolis is a plant‐derived substance collected by honeybees that has a range of potential therapeutic applications. Propolis consists of resins, waxes, and fatty acids, as well as essential oils and other organic compounds. The pharmacologically active components of propolis include phenols and flavonoids, among others.
Yipeng Lin, Janney Z. Wang, Yihe Niu, Ling Zhu, Rujee K. Duke, Colin C. Duke, Michael Murray, Fanfan Zhou   +7 more
wiley   +1 more source

The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing [PDF]

, 2018
Kinetoplastid parasites—trypanosomes and leishmanias—infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies.
Barrett, Michael P., Begolo, Daniela, Bengaly, Zakaria, Clayton, Christine, Freund, Yvonne, Gillingwater, Kirsten, Giordani, Federica, Pöhner, Ina, Rowan, Timothy G., Vincent, Isabel M., Wade, Rebecca C., Witty, Michael J.   +11 more
core   +3 more sources

The Burden of Neglected Tropical Diseases in Rwanda: A Scoping Review

Health Science Reports, Volume 8, Issue 8, August 2025.
ABSTRACT Background and Aims Rwanda is among the African countries affected by neglected tropical diseases (NTDs). This scoping review aims to synthesize available information to understand the prevalence, incidence, distribution, morbidity, mortality, and risk factors of NTDs in Rwanda.
Masceline Jenipher Mutsaka‐Makuvaza, Michael Olubusayo Binuyo, Callixte Cyuzuzo, Acsa Igizeneza, Jean Paul Sinumvayo, Oluwaremilekun Grace Ajakaye, Egie Elisha Enabulele, Zororo Chinwadzimba, Ezera Agwu, Nicholas Midzi   +9 more
wiley   +1 more source