Results 101 to 110 of about 561,822 (204)
2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses
Acta Pharmaceutica, 2020 Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan ...
Serban Georgeta
doaj +1 more source
Trypanotoxic activity of thiosemicarbazone iron chelators. [PDF]
, 2015 Only a few drugs are available for treating sleeping sickness and nagana disease; parasitic infections caused by protozoans of the genus Trypanosoma in sub-Saharan Africa.
Ellis, S, Sexton, DW, Steverding, D
core +1 more source
Anti-trypanosomal activity of secnidazole in vitro and in vivo
, 2017 Purpose : To evaluate the anti-trypanosomal effect of secnidazole (SEC) in vitro and in vivo. Methods: The dose-response effect of SEC in Trypanosoma b. brucei infected rats was evaluated in five groups of rats (n = 5). Group A was infected but untreated;
I. Eke +5 more
semanticscholar +1 more source
Unlocking the potential of bacterial endophytes from medicinal plants for drug discovery
Microbial Biotechnology, Volume 17, Issue 2, February 2024.Bacteria dwelling within tissues of medicinal plants, the so‐called endophytes, represent a unique source of secondary metabolites with diverse biological activities. Modern approaches such as “genome mining” and metabolic engineering provide new opportunities for revealing the biosynthetic potential of bacterial endophytes and assisting in ...
Sergey B. Zotchev
wiley +1 more source
Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]
, 2014 It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer +32 more
core +1 more source
Memorias do Instituto Oswaldo Cruz, 2014 Trypanosoma cruzi has a particular cytoskeleton that consists of a subpellicular network of microtubules and actin microfilaments. Therefore, it is an excellent target for the development of new anti-parasitic drugs.
Dylan L Díaz-Chiguer +6 more
doaj +1 more source
Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications. [PDF]
, 2016 Non-coding RNAs are crucial regulators for a vast array of cellular processes and have been implicated in human disease. These biological processes represent a hitherto untapped resource in our fight against disease.
Amy Cording (1383558) +6 more
core +3 more sources
Advances in Pharmacological and Pharmaceutical Sciences, Volume 2024, Issue 1, 2024.Colorectal cancer (CRC) is a multifactorial disease driven by genetic and epigenetic alterations that modulate specific metabolic pathways. Despite the availability of effective treatments like 5‐fluorouracil (5‐FU), pharmacological therapy for CRC still faces significant challenges, including drug resistance, toxicity, and limited specificity ...
Adriana Milena Olarte Aponte +8 more
wiley +1 more source
Frontiers in Pharmacology, 2018 Moringa is a sole genus of Moringaceae family with 13 species distributed in the tropical and sub-tropical regions. Among them, Moringa peregrina is one of the species which has wide range of traditional, nutritional, industrial, and medicinal values ...
Annadurai Senthilkumar +4 more
doaj +1 more source
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing [PDF]
, 2018 Kinetoplastid parasites—trypanosomes and leishmanias—infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies.
Barrett, Michael P. +11 more
core +3 more sources