Results 111 to 120 of about 581,138 (251)

Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis [PDF]

, 2018
Interest in nitroheterocyclic drugs for the treatment of infectious diseases has undergone a resurgence in recent years. Here we review the current status of monocyclic and bicyclic nitroheterocyclic compounds as existing or potential new treatments for ...
Alan H. Fairlamb, Alliance T.B., Altcheh J., Andrade H.M., Andrade S.G., Andrade S.G., Andrews K.T., Ang C.W., Araldi R.P., Aubé J., Bahia M.T., Bahia M.T., Balasubramanian B., Barreto-Bergter E., Berriman M., Bisser S., Blumenstiel K., Boiani M., Brener Z., Bruhn D.F., Bustamante J.M., Campos M.C., Campos M.C., Chung M.C., Collins A.R., Darsaud A., de Andrade A.L., Deavall D.G., Dikhit M.R., Docampo R., Docampo R., Docampo R., Dodd M.C., Dogra M., El-Sayed N.M., Enanga B., Eperon G., Fabbro D.L., Fairlamb A.H., Fairlamb A.H., Fairlamb A.H., Fernández M.L., Ferreira R.C., Filardi L.S., Fonseca-Berzal C., Garavaglia P.A., Goijman S.G., Gupta S., Gurumurthy M., Hall B.S., Hall B.S., Hayashi M., Henderson G.B., Henderson G.B., Henriques C., Ivens A.C., Jacobs R.T., Janssens P.G., Jeganathan S., Jennings F.W., Kaiser M., Kubata B.K., Lewis M.D., Lewis M.D., Lewis M.D., Likeufack A.C.L., Maina N., Makarov V., Marin-Neto J.A., Marin-Neto J.A., Matsumoto M., Maya J.D., Mejia A.M., Mejía-Jaramillo A.M., Mesu V.K.B.K., Miura K., Moens F., Molina I., Moreno M., Moreno S.N.J., Morillo C.A., Morillo C.A., Mortelmans K., Mukherjee T., Mukkavilli R., Murta S.M., Murta S.M.F., Murta S.M.F., Neal R.A., Nesslany F., Nogoceke E., Nogueira F.B., Nogueira F.B., Olmo F., Panicucci R., Papadopoulou M.V., Papadopoulou M.V., Papadopoulou M.V., Patterson S., Patterson S., Patterson S., Portal P., Priotto G., Priotto G., Pépin J., Pépin J., Raether W., Repetto Y., Rodriques Coura J., Romero A.H., Ryan N.J., Sasahara K., Shimokawa Y., Singh R., Smith D.A., Sokolova A.Y., Stephen Patterson, Stover C.K., Stuart K., Tarleton R.L., Tarral A., Temperton N.J., Thompson A.M., Thompson A.M., Thompson A.M., Thompson A.M., Thompson A.M., Torreele E., Trochine A., Trochine A., Trunz B.B., Tweats D., Urbina J.A., Viodé C., Walsh J.S., Wilkinson S.R., Winkelmann E., Wyllie S., Wyllie S., Wyllie S., Wyllie S., Zhou L.   +141 more
core   +2 more sources

Mechanisms behind the high mortality rate in chronic Chagas cardiomyopathy: Unmasking a three‐headed monster

European Journal of Heart Failure, Volume 26, Issue 12, Page 2502-2514, December 2024.
Main pathophysiological components influencing mortality in chronic Chagas cardiomyopathy. LV, left ventricular; PVC, premature ventricular contraction; VT, ventricular tachycardia. Chagas disease is a neglected tropical disease caused by the parasite Trypanosoma cruzi.
Luis E. Echeverría, Angie Yarlady Serrano‐García, Lyda Z. Rojas, Enrique A. Berrios‐Bárcenas, Juan Esteban Gómez‐Mesa, Sergio A. Gómez‐Ochoa   +5 more
wiley   +1 more source

Potential Trypanocidal Activity of Glycerol Analogues

ChemistryOpen, Volume 13, Issue 12, December 2024.
Trypanosoma brucei is a unicellular parasitic flagellate protozoa causing human African trypanosomiasis and animal African trypanosomiasis. Synthesised glycerol analogues were tested for their potential trypanocidal affects. They caused morphological changes, including detached flagella, cytokinesis defects and ‘big‐eye’ phenotype.
R. A. Humann, T. K. Smith
wiley   +1 more source

Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications

BioFactors, Volume 50, Issue 5, Page 922-956, September/October 2024.
High‐density lipoproteins are versatile lipoprotein nanoparticles that have pleotropic functions in regulating lipid metabolism, innate immunity, and protection of cardiovascular system. They comprise of several proteins among which 15 apolipoproteins are the major proteins, with diverse functions.
Aishwarya Sudam Bhale, Olivier Meilhac, Christian Lefebvre d'Hellencourt, Mookambeswaran A. Vijayalakshmi, Krishnan Venkataraman   +4 more
wiley   +1 more source

A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe3O4‐MWCNT@MnO2 as a reusable catalyst

Applied Organometallic Chemistry, Volume 38, Issue 8, August 2024.
This work aims to explore the catalytic potential of manganese oxide (MnO2) supported on (Fe3O4‐MWCNT) nano‐composite, which is composed of iron oxide and multi‐walled carbon nanotubes. The nano‐composite was synthesized using a simple impregnation technique.
Adapaka Venkateswara Rao, Suresh Maddila, Sai Sonali Anantha, Alice Rinky Robert, Sreekantha B. Jonnalagadda   +4 more
wiley   +1 more source

Insect–microbe interactions and their influence on organisms and ecosystems

Ecology and Evolution, Volume 14, Issue 7, July 2024.
Insect‐symbiont interactions can have a variety of impacts on organisms and the ecosystem. These multitrophic interactions can result in differential attraction of beneficial insects or natural enemies. Additinoally, these interactions can influence plant and/or soil health as well as microbiome composition.
Jocelyn R. Holt, Nathalia Cavichiolli de Oliveira, Raul F. Medina, Antonino Malacrinò, Amelia R. I. Lindsey   +4 more
wiley   +1 more source

Potential Mechanism of the Anti-trypanosomal Activity of Organoruthenium Complexes with Bioactive Thiosemicarbazones

Biological Trace Element Research, 2013
In the search for new metal-based drugs against diseases produced by trypanosomatid parasites, four organoruthenium(II) compounds [Ru2(p-cymene)2(L)2]X2, where L are bioactive 5-nitrofuryl-containing thiosemicarbazones and X = Cl or PF6, had been previously obtained.
Demoro, Bruno, Rossi, Miriam, Caruso, Francesco, Liebowitz, Daniel, Olea Azar, Claudio, Kemmerling Weis, Ulrike, Maya Arango, Juan, Guiset, Helena, Moreno, Virtudes, Pizzo, Chiara, Mahler, Graciela, Otero, Lucía, Gambino, Dinorah   +12 more
openaire   +2 more sources

Advances in QSAR analysis of anti-trypanosomal activity

, 2017
Trypanosomiasis, also known as sleeping sickness, is a vector-borne parasitic disease transmitted by tsetse fly (Glossina genus) and caused by kinetoplastid Trypanosoma. We have investigated quantitative structure–activity relationship (QSAR) of anti-trypanosomal activities of natural compounds polyphenols [1], as well as synthetic compounds: pyridyl ...
Rastija, Vesna, Masand, Vijay H.
openaire   +3 more sources

Benzoic Acid Derivatives with Trypanocidal Activity: Enzymatic Analysis and Molecular Docking Studies toward Trans-Sialidase

Molecules, 2017
Chagas, or American trypanosomiasis, remains an important public health problem in developing countries. In the last decade, trans-sialidase has become a pharmacological target for new anti-Chagas drugs.
Muhammad Kashif, Antonio Moreno-Herrera, Juan Carlos Villalobos-Rocha, Benjamín Nogueda-Torres, Jaime Pérez-Villanueva, Karen Rodríguez-Villar, José Lius Medina-Franco, Peterson de Andrade, Ivone Carvalho, Gildardo Rivera   +9 more
doaj   +1 more source

Intermembrane space‐localized TbTim15 is an essential subunit of the single mitochondrial inner membrane protein translocase of trypanosomes

Molecular Microbiology, Volume 121, Issue 6, Page 1112-1126, June 2024.
TbTim15 is a new subunit of the non‐canonical trypanosomal inner membrane protein translocase. Abstract All mitochondria import >95% of their proteins from the cytosol. This process is mediated by protein translocases in the mitochondrial membranes, whose subunits are generally highly conserved.
Corinne von Känel, Silke Oeljeklaus, Christoph Wenger, Philip Stettler, Anke Harsman, Bettina Warscheid, André Schneider   +6 more
wiley   +1 more source