Results 81 to 90 of about 581,138 (251)

New anti-trypanosomal active tetracyclic iridoid isolated from Morinda lucida Benth. [PDF]

Bioorganic & Medicinal Chemistry Letters, 2015
Human African trypanosomiasis (HAT), commonly known as sleeping sickness has remained a serious health problem in many African countries with thousands of new infected cases annually. Chemotherapy, which is the main form of control against HAT has been characterized lately by the viewpoints of toxicity and drug resistance issues.
Mitsuko, Suzuki, Nguyen Huu, Tung, Kofi D, Kwofie, Richard, Adegle, Michael, Amoa-Bosompem, Maxwell, Sakyiamah, Frederick, Ayertey, Kofi Baffour-Awuah, Owusu, Isaac, Tuffour, Philip, Atchoglo, Kwadwo Kyereme, Frempong, William K, Anyan, Takuhiro, Uto, Osamu, Morinaga, Taizo, Yamashita, Frederic, Aboagye, Alfred Ampomah, Appiah, Regina, Appiah-Opong, Alexander K, Nyarko, Shoji, Yamaoka, Yasuchika, Yamaguchi, Dominic, Edoh, Kwadwo, Koram, Nobuo, Ohta, Daniel A, Boakye, Irene, Ayi, Yukihiro, Shoyama   +26 more
openaire   +2 more sources

Evaluation of enzyme immunoassays in the diagnosis of camel (Camelus dromedarius) trypanosomiasis:a preliminary investigation [PDF]

, 1989
Three enzyme immunoassays were used for the serodiagnosis of Trypanosoma evansi in camels in the Sudan in order to evaluate their ability to discriminate between infected and non-infected animals.
Aitken, C G, Higgins, A, Jones, T W, Luckins, A G, Rae, P F, Thrusfield, M V   +5 more
core   +2 more sources

Orally Active and Selective Tubulin Inhibitors as Anti-Trypanosome Agents

PLOS ONE, 2016
There is an urgent need to develop a safe, effective, orally active, and inexpensive therapy for African trypanosomiasis due to the drawbacks of current drugs. Selective tubulin inhibitors have the potential to be promising drug candidates for the treatment of this disease, which is based on the tubulin protein structural difference between mammalian ...
Vishal Nanavaty, Rati Lama, Ranjodh Sandhu, Bo Zhong, Daniel Kulman, Viharika Bobba, Anran Zhao, Bibo Li, Bin Su   +8 more
openaire   +4 more sources

Cymantrene–Triazole "Click" Products: Structural Characterization and Electrochemical Properties [PDF]

, 2014
We report the first known examples of triazole-derivatized cymantrene complexes (η5-[4-substituted triazol-1-yl]cyclopentadienyl)tricarbonylmanganese(I), obtained via a “click” chemical synthesis, bearing a phenyl, 3-aminophenyl, or 4-aminophenyl moiety ...
Abboud J.-L. M., Anderson C. B., Astruc D., Badèche S., Baltz T., Beyer B., Bock V. D., Borissova A. O., Calladine J. A., Carvalho I., Chong D., Clough M. C., Dallagi T., David P. Day, David. L. Hughes, Dietmar Steverding, Evrard D., Geiger W. E., Geiger W. E., Gil M. V., Glans L., Gregory G. Wildgoose, Gritzner G., Happ B., Hirano T., Hirumi H., Holovics T. C., Huber W., Huisgen R., Jaschinski T., Kee J. W., Kilpin K. J., Kolb H. C., Kolb H. C., Lage M. L., Lawrence E. J., Laws D. R., Laws D. R., Leroux Y. R., Leroux Y. R., Liu Y., Lunquist R. T., Ornelas C., Ornelas C., Otón F., Otón F., Rapakousiou A., Romero T., Romero T., Romero T., Schweinfurth D., Schweinfurth D., Schweinfurth D., Sheridan M. V., Steverding D., Sünkel K., Thomas Dann, To T. T., Vasily S. Oganesyan, Yoo E. J.   +59 more
core   +1 more source

Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide [PDF]

, 2016
Introduction: Trypanosoma brucei is the causative agent of human African trypanosomiasis, which is responsible for thousands of deaths every year. Current therapies are limited and there is an urgent need to develop new drugs.
Avery, Vicky M., Baell, Jonathan B., Creek, Darren J., Ellis, Katherine M., Ferrins, Lori, Jones, Amy J., McConville, Malcolm J., Nowell, Cameron J., Rahmani, Raphael, Read, Kevin D., Riley, Jennifer, Stoessel, Daniel   +11 more
core   +2 more sources

In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)

Química Nova, 2012
Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized.
Patricia Sartorelli, Jefferson S. Santana, Rafael C. Guadagnin, João Henrique G. Lago, Érika G. Pinto, André G. Tempone, Hélio A. Stefani, Marisi G. Soares, Adalberto M. da Silva   +8 more
doaj   +1 more source

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. [PDF]

, 2010
BackgroundCruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease.
Brinen, Linda S, Chen, Yen Ting, Doyle, Patricia S, Hansell, Elizabeth, Kerr, Iain D, McKerrow, James H, Roush, William R   +6 more
core   +3 more sources

Evaluating 5-nitrofurans as trypanocidal agents [PDF]

, 2013
The nitroheterocycle nifurtimox, as part of a nifurtimox-eflornithine combination therapy, represents one of a limited number of treatments targeting Trypanosoma brucei, the causative agent of human African trypanosomiasis.
Alvarez, G, Bot, C, Cerecetto, H, Di Maio, D, Gonzalez, M, Hall, BS, WILKINSON, SR   +6 more
core   +1 more source

A broad distribution of the alternative oxidase in microsporidian parasites [PDF]

, 2010
Microsporidia are a group of obligate intracellular parasitic eukaryotes that were considered to be amitochondriate until the recent discovery of highly reduced mitochondrial organelles called mitosomes. Analysis of the complete genome of Encephalitozoon
A Atteia, A Stechmann, AD Tsaousis, AE McDonald, AL Moore, AL Moore, AL Umbach, Anthony L. Moore, AV Goldberg, BA Williams, BA Williams, BA Williams, Bryony A. P. Williams, C Affourtit, C Larsson, C Nihei, Catherine Elliot, CH Slamovits, CR Vossbrinck, CW Roberts, DA Berthold, DE Akiyoshi, E Weidner, ES Didier, ES Didier, F Thomarat, GC Vanlerberghe, GV Beznoussenko, I Small, JA Eisen, JD Thompson, JP Huelsenbeck, K Kita, Kiyoshi Kita, Lena Burri, M Chaudhuri, M Nina, MD Katinka, MG Claros, MJ Gardner, MS Albury, MS Albury, MS Albury, N Minagawa, O Emanuelsson, P Stenmark, Patricia J. Johnson, Patrick J. Keeling, PG Crichton, PJ Didier, PJ Keeling, R George, RP Hirt, RS Cornman, S Guindon, SJ Qureshi, T Joseph-Horne, T Suzuki, TA Richards, TD Edlind, TE Elthon, TM Keane, W Jarmuszkiewicz, Y Fukai, Yasutoshi Kido   +64 more
core   +4 more sources

Chemical Composition, Antioxidant, and Antibacterial Activities of Mezilaurus duckei (Lauraceae)

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Mezilaurus duckei, a Brazilian endemic tree species found exclusively in the Amazon Rainforest, is primarily exploited for timber in construction. Due to its endangered status, this study aimed to investigate the chemical profile and biological properties of the ethanolic extract and its phases derived from M. duckei leaves. Chemical profiling
Bruna S. Moroto, Valéria S. Gonçalves, David J. Machate, Talita V. Freire, Érica L. Santos, Flávio M. Alves, Ana C. Micheletti, Nídia C. Yoshida   +7 more
wiley   +1 more source