Anti-trypanosomal activity of secnidazole in vitro and in vivo
, 2017 Purpose : To evaluate the anti-trypanosomal effect of secnidazole (SEC) in vitro and in vivo. Methods: The dose-response effect of SEC in Trypanosoma b. brucei infected rats was evaluated in five groups of rats (n = 5). Group A was infected but untreated;
I. Eke +5 more
semanticscholar +1 more source
Heliyon, 2019 Poly(amidoamine) and Poly(propylenimine) dendrimers with different generations and peripheral groups were studied as solubility enhancers and nanocarriers for 7-bromo-2-hydroxy-phenazine N5,N10-dioxide.
Nahir Dib +9 more
doaj +1 more source
Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicals. [PDF]
PLoS Neglected Tropical Diseases, 2014 BACKGROUND: The silent-information regulator 2 proteins, otherwise called sirtuins, are currently considered as emerging anti-parasitic targets. Nicotinamide, a pan-sirtuin inhibitor, is known to cause kinetoplast alterations and the arrested growth of T.
Lionel Sacconnay +7 more
doaj +1 more source
Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine [PDF]
, 2017 Sleeping sickness is an infectious disease that is caused by the protozoan parasite Trypanosoma brucei. The second stage of the disease is characterised by the parasites entering the brain.
Rushworth, Stuart A. +1 more
core +1 more source
Anais da Academia Brasileira de Ciências, 2013 The present investigation was to evaluate the potential trypanocidal activity of crude ethanolic extract of the fruits of Solanum palinacanthum, Solanum lycocarpum and the glycoalcaloid, solamargine. S. palinacanthum and S.
RAQUEL R.D. MOREIRA +6 more
doaj +1 more source
2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses
Acta Pharmaceutica, 2020 Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan ...
Serban Georgeta
doaj +1 more source
Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications. [PDF]
, 2016 Non-coding RNAs are crucial regulators for a vast array of cellular processes and have been implicated in human disease. These biological processes represent a hitherto untapped resource in our fight against disease.
Amy Cording (1383558) +6 more
core +3 more sources
Anti-Trypanosomal Activity of Guiera senegalensis on Trypanosoma brucei Infected Mice
Journal of Drug Delivery and Therapeutics, 2019 Aqueous decoction of Guiera senegalensis leaves was studied orally and intraperitoneally for its antitrypanosomal activity on mice infected experimentally with Trypanosoma brucei brucei. After a phytochemical screening followed by an acute toxicity study
Zongo André +6 more
semanticscholar +1 more source
Inhibition of Bacterial RNase P RNA by Phenothiazine Derivatives
Biomolecules, 2016 There is a need to identify novel scaffolds and targets to develop new antibiotics. Methylene blue is a phenothiazine derivative, and it has been shown to possess anti-malarial and anti-trypanosomal activities.
Shiying Wu +2 more
doaj +1 more source
Trypanotoxic activity of thiosemicarbazone iron chelators. [PDF]
, 2015 Only a few drugs are available for treating sleeping sickness and nagana disease; parasitic infections caused by protozoans of the genus Trypanosoma in sub-Saharan Africa.
Ellis, S, Sexton, DW, Steverding, D
core +1 more source