Results 81 to 90 of about 561,822 (204)

DNA minor groove binders-inspired by nature [PDF]

, 2016
The synthesis and biological activity of a variety of analogues to the naturally occurring anti-bacterial and anti-fungal Distamycin A were explored by a number of authors. These compounds were subject to a large array of assays.
Al-Khadhimi, Ahmed A. H, Ali, Jaafar H., Khalaf, Abedawn I.   +2 more
core   +2 more sources

Potential Trypanocidal Activity of Glycerol Analogues

ChemistryOpen, Volume 13, Issue 12, December 2024.
Trypanosoma brucei is a unicellular parasitic flagellate protozoa causing human African trypanosomiasis and animal African trypanosomiasis. Synthesised glycerol analogues were tested for their potential trypanocidal affects. They caused morphological changes, including detached flagella, cytokinesis defects and ‘big‐eye’ phenotype.
R. A. Humann, T. K. Smith
wiley   +1 more source

Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors. [PDF]

PLoS Neglected Tropical Diseases, 2015
A series of compounds based on the dipeptidyl nitrile scaffold were synthesized and assayed for their inhibitory activity against the T. cruzi cysteine protease cruzain.
Leandro A A Avelar, Cristian D Camilo, Sérgio de Albuquerque, William B Fernandes, Cristiana Gonçalez, Peter W Kenny, Andrei Leitão, James H McKerrow, Carlos A Montanari, Erika V Meñaca Orozco, Jean F R Ribeiro, Josmar R Rocha, Fabiana Rosini, Marta E Saidel   +13 more
doaj   +1 more source

Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications

BioFactors, Volume 50, Issue 5, Page 922-956, September/October 2024.
High‐density lipoproteins are versatile lipoprotein nanoparticles that have pleotropic functions in regulating lipid metabolism, innate immunity, and protection of cardiovascular system. They comprise of several proteins among which 15 apolipoproteins are the major proteins, with diverse functions.
Aishwarya Sudam Bhale, Olivier Meilhac, Christian Lefebvre d'Hellencourt, Mookambeswaran A. Vijayalakshmi, Krishnan Venkataraman   +4 more
wiley   +1 more source

African Trypanosomes undermine humoral responses and vaccine development : link with inflammatory responses? [PDF]

, 2017
African trypanosomosis is a debilitating disease of great medical and socioeconomical importance. It is caused by strictly extracellular protozoan parasites capable of infecting all vertebrate classes including human, livestock, and game animals.
Achcar, Alampour-Rajabi, Alirol, Allman, Authie, Authié, Auty, Baker, Balber, Banks, Barry, Barry, Berthier, Beschin, Beschin, Blom-Potar, Bockstal, Bockstal, Boller, Bonnet, Borst, Bosschaerts, Boulange, Bouyer, Brun, Brun, Bucheton, Calandra, Capewell, Chamond, Claes, Cnops, Cnops, Cnops, Cnops, Coller, Dagenais, Darji, De Muylder, De Trez, Delafosse, Delespaux, Desquesnes, Devine, Disease, Drennan, Dubois, Duszenko, Engstler, Fenn, Ferrante, Field, Figarella, Franco, Frenkel, Gilbert, Giordani, Gomez-Rodriguez, Graham, Graham, Haanstra, Hall, Hasker, Hemphill, Holland, Holland, Holt, Jamonneau, Jarvinen, Jones, Keitany, Kennedy, Kennedy, Klasen, Kondo, Kroubi, Kuriakose, La Greca, La Greca, Lalmanach, Lanca, Lebien, Lejon, Lejon, Leng, MacGregor, MacGregor, MacLean, MacLean, Magez, Magez, Magez, Mansfield, McGettrick, Mekori, Millar, Mogk, Mony, Morrison, Morrison, Morrison, Mulindwa, Mårtensson, Naessens, Naula, Ng, Nutt, Obishakin, Odongo, Onyilagha, Ooi, Ooi, Osório, O’Gorman, Paulnock, Pays, Peacock, Priotto, Radwanska, Radwanska, Reth, Rico, Rodgers, Rotureau, Ruiz-Postigo, Salmon, Schwede, Schwede, Seed, Sharpe, Sileghem, Sileghem, Simarro, Simarro, Simarro, Stijlemans, Stijlemans, Stijlemans, Stijlemans, Stijlemans, Stijlemans, Stijlemans, Swallow, Takeya, Taylor, Taylor, Taylor, Telleria, Tiberti, Trindade, Unciti-Broceta, Uzonna, Uzonna, Van Den Abbeele, Vassella, Welburn, Welburn, Wellde, Wenzler, Willert, Yaro   +160 more
core   +1 more source

A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe3O4‐MWCNT@MnO2 as a reusable catalyst

Applied Organometallic Chemistry, Volume 38, Issue 8, August 2024.
This work aims to explore the catalytic potential of manganese oxide (MnO2) supported on (Fe3O4‐MWCNT) nano‐composite, which is composed of iron oxide and multi‐walled carbon nanotubes. The nano‐composite was synthesized using a simple impregnation technique.
Adapaka Venkateswara Rao, Suresh Maddila, Sai Sonali Anantha, Alice Rinky Robert, Sreekantha B. Jonnalagadda   +4 more
wiley   +1 more source

Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicals. [PDF]

PLoS Neglected Tropical Diseases, 2014
BACKGROUND: The silent-information regulator 2 proteins, otherwise called sirtuins, are currently considered as emerging anti-parasitic targets. Nicotinamide, a pan-sirtuin inhibitor, is known to cause kinetoplast alterations and the arrested growth of T.
Lionel Sacconnay, Melissa Angleviel, Giuseppe Marco Randazzo, Marcos Marçal Ferreira Queiroz, Emerson Ferreira Queiroz, Jean-Luc Wolfender, Pierre-Alain Carrupt, Alessandra Nurisso   +7 more
doaj   +1 more source

Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies : African trypanosomes as paradign [PDF]

, 2004
Antigen variation is a successful defense system adopted by several infectious agents to evade the host immune response. The principle of this defense strategy in the African trypanosome paradigm involves a dense packing of variant surface glycoproteins (
Conrath, Katja, Cortez-Retamozo, Virna, De Baetselier, Patrick, Magez, Stefan, Muyldermans, Serge, Revets, Hilde, Senter, Peter, Stijlemans, Benoît, Van Xong, Hoang, Wyns, Lode   +9 more
core   +2 more sources

Anti-Trypanosomal Activity of Guiera senegalensis on Trypanosoma brucei Infected Mice

Journal of Drug Delivery and Therapeutics, 2019
Aqueous decoction of Guiera senegalensis leaves was studied orally and intraperitoneally for its antitrypanosomal activity on mice infected experimentally with Trypanosoma brucei brucei. After a phytochemical screening followed by an acute toxicity study
Zongo André, V. Hervé, Bengaly Zakaria, K. Adama, Traoré Aristide, Tamboura Hamidou Hamadou, B. A. Gaston   +6 more
semanticscholar   +1 more source

Insect–microbe interactions and their influence on organisms and ecosystems

Ecology and Evolution, Volume 14, Issue 7, July 2024.
Insect‐symbiont interactions can have a variety of impacts on organisms and the ecosystem. These multitrophic interactions can result in differential attraction of beneficial insects or natural enemies. Additinoally, these interactions can influence plant and/or soil health as well as microbiome composition.
Jocelyn R. Holt, Nathalia Cavichiolli de Oliveira, Raul F. Medina, Antonino Malacrinò, Amelia R. I. Lindsey   +4 more
wiley   +1 more source