Results 101 to 110 of about 7,382,706 (304)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

From Values to Anti-values of the European Union Law

open access: yesPrzegląd Prawa Administracyjnego
The study is an attempt at a general, synthetic reflection on the values and anti-values of European Union (EU) law, that is why the analysis of specific legal institutions has been limited to the necessary minimum. Paradoxically, the anti-values of EU law are associated with: the process of universalization of values expressed by this law; axiological
openaire   +1 more source

THE TANNER LECTURES ON HUMAN VALUES, VOLUME 15

open access: yes, 1994
The Tanner Lectures on Human Values -- The trustees -- Preface to volume 15 -- The Israeli-Palestinian conflict: tragedy, comedy, and cognitive block - a storyteller s point of view / Amos Oz - The sources of normativity / Christine M.
Peterson, Grethe B., ed.
core  

Anti-oxidative capability.

open access: yes, 2016
The anti-oxidative activity of HDL was determined by inhibition of AAPH-initiated oxidation of the fluorescent dye dihydrorhodamine (DHR). Incubation of DHR in presence of apoB-depleted sera from healthy subjects or AMD patients led to a reduction in the
Anton Haas (420487)   +9 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Corruption, Politics and Societal values in Tanzania: An evaluation of the Mkapa administration's anti corruption efforts

open access: yesAfrican Journal of Political Science, 2004
Array
Bruce Heilman, Lawrean Ndumbaro
doaj  

The problem of defining and formation of anti-value: a methodological aspect

open access: yesВестник Пермского университета. Философия. Психология. Социология
The paper is related to popularization of the phenomenon of anti-value. The main problem of the article is defining anti-value as a radical opposition to value being an axiologically positive phenomenon. In such a paradigm, the former is not just negative but «value-destroying», that is, it is full of destructive tendencies.
openaire   +1 more source

Christian Anti-Communism Crusade - Invitation to a lecture by Dr. F.C. Schwarz

open access: yes, 1963
Christian Anti-Communism Crusade - Invitation to a lecture by Dr.
Christian Anti-Communism Crusade
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Anti-values in (Children's Book) by Latif Halmat

open access: yesJournal of University of Raparin
The work which is entitled (Anti-values in (Children's Book) by Latif Halmat) attempts to exhibits those anti-values mentioned in this book. Several kinds of anti-values appear that effect on individual and society as lying, cheating, betrayal, violence, harassment .... etc.
openaire   +1 more source

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