Results 121 to 130 of about 2,259,235 (294)

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Prophage Activation Triggers Extracellular Synthesis of DNA in Bacterial Biofilms via Rolling Circle Replication

Angewandte Chemie, EarlyView.
Shewanella oneidensis and Bacillus subtilis, both harboring prophages, reveal a novel biosynthetic route to scalable and programmable DNA superstructures in flower‐ and wire‐like shapes, respectively. Activation of prophages is achieved via 3‐hour starvation and monitored using reporter strains.
Gabriel Antonio S. Minero, Line Mørkholt Lund, Lasse Hyldgaard Klausen, Obinna Markraphael Ajunwa, Mingdong Dong, Rikke Louise Meyer, Victoria Birkedal, Kai Thormann   +7 more
wiley   +2 more sources

The influence of an innovative antibacterial drug of the thiadiazinone class on the virulence factors of bacteria of the phylum Pseudomonadota, which chronically infect patients with cystic fibrosis

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Infections of the lower respiratory tract by bacteria of the Pseudomonadota phylum: Pseudomonas aeruginosa, Burkholderia spp., Achromobacter spp. are critical to the quality and life expectancy of patients with cystic fibrosis (CF).
Olga L. Voronina, Ekaterina A. Koroleva, Marina S. Kunda, Natalia N. Ryzhova, Ekaterina I. Aksenova, Lidia N. Kapotina, Stanislava A. Nelubina, Anna V. Lazareva, Nailya A. Zigangirova   +8 more
doaj   +1 more source

The Identification, Isolation and Partial Characterisation of VapA-encoding virulence plasmids in Rhodococcus equi found in New Zealand. [PDF]

, 2010
This thesis describes the identification, isolation and partial characterisation of VapA-encoded virulence plasmids present in Rhodococcus equi (R. equi) found in foals in New Zealand. R.
Singh, Niharika
core  

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Advanced Science, EarlyView.
Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu, Kang Wang, Kwet Kyawl Yan, Zhikai Xu, Xuan Zhao, Xiangjun Bai, Zhanfei Li, Yuchang Wang   +7 more
wiley   +1 more source

Disarming Salmonella virulence with 32H-hilE anti-virulence bacteriophage

Microbiological Research
As the development of new antibiotics struggles with the continuous emergence of drug-resistant bacteria, targeting bacterial virulence factors instead of viability has been proposed as one of the alternative approaches to combat the pathogens. Here, we genetically engineered the temperate phage SPC32H to serve as a delivery vehicle for key negative ...
Jinwoo Kim, Haejoon Park, Young Hyun Jung, Ho Jae Han, Doyeon Kim, Sangryeol Ryu, Minsik Kim   +6 more
openaire   +2 more sources

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Senna petersiana (Bolle) Lock: A Review of Its Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicological Profile

Plants
Senna petersiana (Bolle) Lock is a chemically diverse plant widely recognized for its ethnomedicinal applications across various traditional medical systems.
Talita Jessica Mnisi, Mashilo Mash Matotoka, Peter Masoko   +2 more
doaj   +1 more source

FAM134B Restricts African Swine Fever Virus Capsid Assembly via Reticulophagy and Its Antiviral Activity is Antagonized by the Viral Virulence‐Associated Factor pMGF300‐2R

Advanced Science, EarlyView.
ABSTRACT African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating viral disease in domestic pigs and wild boar. ASFV is a large DNA virus whose capsid assembly takes place within perinuclear viral factories (VFs). Accumulating evidence has demonstrated that reticulophagy confers antiviral activity against multiple RNA ...
Rui Luo, Jing Zhang, Ruojia Huang, Xianfeng Zhang, Lian‐Feng Li, Jing Lan, Zhanhao Lu, Yuan Sun, Tao Wang, Hua‐Ji Qiu   +9 more
wiley   +1 more source

TroA of Streptococcus suis is required for manganese acquisition and full virulence [PDF]

, 2011
Streptococcus suis causes infections in pigs and occasionally in humans resulting in 23 manifestations as meningitis, sepsis, arthritis and septic shock. For survival within the 24 host, S. suis requires numerous nutrients including trace metals.
Smith, H.E., Rebel, M.J., Wichers Schreur, P.J., Rebel, J.M.J., van Putten, J.P.M., Jos P. M. van Putten, Johanna M. J. Rebel, Mari A. Smits, Paul J. Wichgers Schreur, Smits, M.A., Hilde E. Smith, Wichgers Schreur, P.J., Putten, J.P.M., van   +12 more
core   +1 more source