Results 101 to 110 of about 2,259,235 (294)

Study of anti-resistance and anti-virulence effects of two antimicrobialmolecules on Gram positive pathogens

, 2022
International audienceIntroduction et objectifsLes Entérocoques et Staphylocoques sont responsables de nombreuses infections associées aux soins. Ces organismes présentent des résistances à divers antibiotiques dont la vancomycine.
Baëtz, Benjamin, Boudrioua, Abdelhakim, Giraud, Caroline, Li, Yanyan, Desmadril, Solenn, Hartke, Axel   +5 more
core   +2 more sources

The BTB/POZ‐MATH Protein ZmBPM1 Interacts With Autophagy‐related Protein ZmATG6 and Modulates the NLR Protein Rp1‐D21‐Mediated Defense Response in Maize

Advanced Science, EarlyView.
The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Chang‐Xiao Tang, Tong‐Tong Liu, Qi‐Dong Ge, Xiao‐Ying Liu, Wanxiao Wang, Yang Sun, Yanfei Liu, Faqiang Li, Guan‐Feng Wang   +8 more
wiley   +1 more source

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK‐Binding Osteoclastogenic Factor

Advanced Science, EarlyView.
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park, Yeongkag Kwon, Yeonjin Lim, Jeong Woo Park, Hyun Jung Ji, Dongwook Lee, Jueun Lee, Sung‐Ho Yun, Sungho Jeong, Ho Seong Seo, Kun Cho, Cheol‐Heui Yun, Ok‐Jin Park, Seung Hyun Han   +13 more
wiley   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Virulence

, 2015
Waxmoth virulence data.
Harrison, Freya, Kar-Wai Hong (3268704), Chan, Kok-Gan, Paul Williams (191800), Stuart A. West (182935), Freya Harrison (63920), West, Stuart A., Eric Pollitt (3268698), Hong, Kar-Wai, Diggle, Stephen P., Roman Popat (471112), Griffin, Ashleigh S., Popat, Roman, Hardeep Naghra (3268707), Williams, Paul, Pollitt, Eric, Sam P. Brown (30600), Kok-Gan Chan (531824), Ashleigh S. Griffin (273184), Brown, Sam P., Stephen P. Diggle (471113), Naghra, Hardeep   +21 more
core   +1 more source

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

Advanced Science, EarlyView.
Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong, Xingjin Li, Tao Hu, Qianqian Lu, Xiaoxu Zhang, Xi Chen, Yifan Luo, Zhong Zuo, Ronald Man Yeung Wong, Miao Xu, Tiancong Zhao, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Structure-Function Relationships of the Neisserial EptA Enzyme Responsible for Phosphoethanolamine Decoration of Lipid A: Rationale for Drug Targeting

Frontiers in Microbiology, 2018
Bacteria cause disease by two general mechanisms: the action of their toxins on host cells and induction of a pro-inflammatory response that can lead to a deleterious cytokine/chemokine response (e.g., the so-called cytokine storm) often seen in ...
Charlene M. Kahler, Charlene M. Kahler, K. L. Nawrocki, K. L. Nawrocki, A. Anandan, Alice Vrielink, Alice Vrielink, William M. Shafer, William M. Shafer   +8 more
doaj   +1 more source

Membrane-Interactive Compounds From Pistacia lentiscus L. Thwart Pseudomonas aeruginosa Virulence

Frontiers in Microbiology, 2020
Pseudomonas aeruginosa is capable to deploy a collection of virulence factors that are not only essential for host infection and persistence, but also to escape from the host immune system and to become more resistant to drug therapies.
Ali Tahrioui, Sergio Ortiz, Onyedikachi Cecil Azuama, Emeline Bouffartigues, Nabiha Benalia, Damien Tortuel, Olivier Maillot, Smain Chemat, Marina Kritsanida, Marc Feuilloley, Nicole Orange, Sylvie Michel, Olivier Lesouhaitier, Pierre Cornelis, Raphaël Grougnet, Sabrina Boutefnouchet, Sylvie Chevalier   +16 more
doaj   +1 more source

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

In vitro and in vivo antifungal effects of fluconazole in combination with Cinnamomum verum essential oil against Candida spp

Frontiers in Pharmacology
IntroductionAntifungal resistance in Candida species is a growing clinical problem globally, especially in immunocompromised patients. One of the alternative approaches to conventional therapies are currently based on essential oils (EOs) alone or in ...
Marina Ionela Nedea, Serena-Ștefania Velicu, Ioana Cristina Marinaş, Mihaela Buleandră, Andreea Letiția Arsene, Bruno Ștefan Velescu, Mariana Carmen Chifiriuc, Mariana Carmen Chifiriuc, Mariana Carmen Chifiriuc, Irina Gheorghe-Barbu, Irina Gheorghe-Barbu   +10 more
doaj   +1 more source