Results 61 to 70 of about 39,168 (176)

Cumulative incidence and treatment effectiveness of low bone mineral density among people living with HIV in Iran (2021–2023)

AIDS Research and Therapy
Background The introduction of antiretroviral therapy (ART) has significantly improved the life expectancy of people living with HIV (PLHIV), leading to an increased prevalence of age-related comorbidities such as osteoporosis.
Hamidreza Rashidi, Soheil Mehmandoost, Noushin Fahimfar, Seyed Mohammad Hosseinian, Mohammad Reza Shakibi, Tarlan Hasan Aghaei, Farzaneh Yazdi Yahaabadi, Pouriya Salajegheh, Willi Mcfarland, Afshin Ostovar, Hamid Sharifi   +10 more
doaj   +1 more source

Out-of-pocket Expenditure and its Impact on the Quality of Life among Patients Attending the Anti-retroviral Therapy Centre of a Tertiary Care Hospital in Kolkata [PDF]

Healthline
Introduction: Out-of-pocket expenditure (OOPE) has a negative impact on Quality of life (QoL) of People Living with HIV (PLHIV)which can increase the risk of slipping into poverty. Objectives: Primary Objective of this study was to estimate the burden of
Mamunur Rashid, Dipendra Narayan Goswami, Kuntala Ray, Mausumi Basu, Aparajita Mondal, Abhipsa Dey   +5 more
doaj   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, Volume 13, Issue 36, 29 June 2026.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

HIV-1 integrase resistance in the context of antiretroviral therapy in paediatric patients ‒ Northeast Brazil

Brazilian Journal of Infectious Diseases
Introduction: Antiretroviral drug resistance poses a challenge to therapy efficacy. Although Integrase Strand Transfer Inhibitors (INSTIs) have a high genetic barrier to resistance, few studies in Brazil have focused on INSTI resistance. This study aimed
Aldicléya Lima Luz, Élcio Leal, Kledoaldo Lima, Mikhael Morais de Souza, Michelle Lima de Carvalho Silva, Mayra Moura Lima, Paloma Gomes Tavares Sette, Yasmim Leandra Moura de Almeida, Heloísa Ramos Lacerda de Melo   +8 more
doaj   +1 more source

Prevalence of acquired and transmitted HIV drug resistance in Iran: a systematic review and meta-analysis

BMC Infectious Diseases
Background There is no systematic review on the prevalence of HIV drug resistance (HIVDR) in Iran. We aimed to estimate the prevalence of HIVDR among people living with HIV (PLHIV) in Iran.
Hossein Mirzaei, Sana Eybpoosh, Fatemeh Mehrabi, Mohammad Reza Shojaei, Ali Mirzazadeh, Mehrdad Khezri, Naser Nasiri, Hamid Sharifi   +7 more
doaj   +1 more source

Tumour‐Derived Extracellular Vesicles Induce Diffuse Large B‐Cell Lymphoma Progression Through Macrophage‐Mediated MDSC Accumulation

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Elevated peripheral myeloid‐derived suppressor cells (MDSCs) predicted suppressed anti‐tumour immunity and poor prognosis in diffuse large B‐cell lymphoma (DLBCL) patients. Here we demonstrated that tumour‐derived extracellular vesicles (EVs) served as a messenger, delivering cholesterol from lymphoma cells to macrophages.
Mengke Liu, YingYu Dong, Qixiao Guan, JianBiao Wang, Qing Shi, RongGui Lin, Muchen Zhang, Di Fu, Shu Cheng, Pengpeng Xu, Eurydice Angeli, Guilhem Bousquet, Wenguo Cui, Hongjing Dou, Wei‐Li Zhao, Li Wang   +15 more
wiley   +1 more source

Shigella flexneri associated reactive arthritis - GI transmitted or sexually transmitted?

Journal of Family Medicine and Primary Care, 2019
The pathogenic association of reactive arthritis with human immunodeficiency virus (HIV) needs more attention. In this case report we described a case of 22 year old male patient suffering from severe HIV infection.
Nidhi Kaeley, Manish Kumar, Bharat B Bhardwaj, Vempalli Nagasubramanyam   +3 more
doaj   +1 more source

The prevalence of antiretroviral drug interactions with other drugs used in women living with HIV and its association with HIV drug change and patient compliance

BMC Infectious Diseases
Background Drug-drug interactions (DDIs) between antiretroviral therapy (ART) and commonly used co-medications in HIV patients, especially women, impact treatment efficacy and patient safety.
Mohammadreza Heydari, Zohre Foroozanfar, Sina Bazmi, Zahra Mohammadi, Hassan Joulaei, Ghavam Ansari   +5 more
doaj   +1 more source

Rejoinder to Commentaries on “A Perspective on the Appropriate Implementation of ICH E9(R1) Addendum Strategies for Handling Intercurrent Events”

Statistics in Medicine, Volume 45, Issue 15-17, July 2026.
Thomas R. Fleming, Kevin J. Carroll, Janet T. Wittes, Scott S. Emerson, Mark D. Rothmann, Sylva Collins, Gregory Levin   +6 more
wiley   +1 more source