Results 81 to 90 of about 42,053 (270)

Anti‐cancer drugs targeting the NADH‐binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity

The FEBS Journal, EarlyView.
VA molecules alter VDAC1 gating by increasing anion flow and reducing cation permeability. In cancer cells, which rely on ER‐mitochondria Ca2+ transfer and overexpress VDAC1, this imbalance triggers bioenergetic stress, ROS buildup, and mitochondrial collapse, leading to cell death.
Stefano Conti‐Nibali, Giuseppe Battiato, Salvatore Antonio Maria Cubisino, Cristina Arrigoni, Marco Lolicato, Simona Reina, Vito De Pinto   +6 more
wiley   +1 more source

Acute Effects on Signal-Averaged Electrogram Parameters and Suppressing Premature Ventricular Contractions in Single or Combined Use of Class I Antiarrhythmic Drugs

Journal of Arrhythmia, 2006
Disopyramide (DP), mexiletine (MX), and flecainide (FL) are class I antiarrhythmic drugs. However, these drugs exert different effects on the electrocardiogram (ECG) based on their unique actions on cardiac myocytes.
Shin-ichiro Kamei, Takao Katoh, Toshihiko Ohara, Masafumi Kanemura, Shin-ichi Kuroki, Teruo Takano   +5 more
doaj   +1 more source

Atrial remodeling in permanent atrial fibrillation : Mechanisms and pharmacological implications [PDF]

, 2013
Atrial fibrillation (AF), the most prevalent rhythm disorder in clinical practice, is currently significantly contributing to morbidity and mortality of the ageing population.
Fazekas, Tamás, Jost, Norbert, Kohajda, Zsófia, Muntean, Danina M.   +3 more
core   +1 more source

Catheter Ablation: Evolution and Efficiencies

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT The present review includes a discussion the goals and pitfalls of efficiency in the medical profession, a historical perspective on the evolution of catheter ablation in the field of electrophysiology (EP), and the data regarding the relationship between efficiency and outcomes in the EP lab. Focus on efficacy is critical to maximize resource
Aravind G. Kalluri, Bradley P. Knight
wiley   +1 more source

Bilateral cardiac sympathetic denervation of a recurrent refractory ventricular tachycardia occurring after catheter ablation of atrial fibrillation and outflow tract premature ventricular contractions

Journal of Arrhythmia, 2019
Recent studies have demonstrated the utility of cardiac sympathetic denervation (CSD) in patients with ventricular tachycardia (VT) refractory to antiarrhythmic drugs and catheter or surgical ablation.
Atsuhiko Yagishita, Masahiko Goya, Yoshihide Takahashi, Hironori Ishibashi, Kikou Akiyoshi, Masahiro Sekigawa, Shingo Maeda, Mihoko Kawabata, Kenichi Okubo, Kenzo Hirao   +9 more
doaj   +1 more source

Prognostic Impact of New‐Onset Atrial Fibrillation After Cardiac Arrest: Observations From a Federated Research Network

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Data on adverse events in patients developing atrial fibrillation (AF) after cardiac arrest (CA) are limited. Methods Retrospective analysis using the TriNetX network. Adults (≥ 18 years) with CA (ICD‐10‐CM I46) from 2014 to 2024 were divided into two cohorts: those with new‐onset AF (I48) within 2 days after CA and those without ...
Enrico Tartaglia, Tommaso Bucci, Amir Askarinejad, Michele Rossi, Muath Alobaida, Steven Ho Man Lam, Mert Kaskal, Andrea Galeazzo Rigutini, Shir Lynn Lim, Giuseppe Boriani, Gregory Y. H. Lip   +10 more
wiley   +1 more source

Anticholinergic activity and pharmacokinetic parameters of agent SS-68 with properties of class III antiarrhythmic drugs [PDF]

, 2016
It was shown that the indole derivate SS-68 (50 and 250 μg/kg intravenous) in acute experiments on cats with neurogenic atrial fibrillation (AF) has a dose-dependent antiarrhythmic action which is associated with the neurotropic influence of this ...
Bogus, S. K., Galenko-Yaroshevskii, P. A., Kulikov, A. L., Suzdalev, K. P., Vinakov, D. V.   +4 more
core   +2 more sources

Real‐Time 3D Mapping Corrects Fluoroscopic Misperception During Pulmonary Vein Isolation by Pulsed Field Ablation

Journal of Cardiovascular Electrophysiology, EarlyView.
In a three‐phase comparison (fluoroscopy‐only, 3D‐blinded, and real‐time 3D‐EAM), 23.8% of blinded procedures missed at least one pulmonary vein. Real‐time 3D mapping eliminated missed veins and reduced PVI applications. 3D‐EAM, three‐dimensional electroanatomical mapping; CT, computed tomography; LA, left atrium; PV, pulmonary vein.
Grégoire Massoullié, Saer Abu‐Alrub, Frederic Jean, Antoine Boudias, Pierre Antoine Catalan, Clément Riocreux, Bruno Pereira, Guillaume Clerfond, Romain Eschalier   +8 more
wiley   +1 more source

Efficiency of phencarol in combination with standard antiarrhythmic drugs in extrasystoles in children

RUDN Journal of Medicine, 2008
The efficiency of multimodality therapy with use standard antiarrhythmic drugs (cordaron and propanorm) in minimum efficient doses and phencarol (1-2 mg/kg) was investigated in 50 children's with extrasistoles, class II-IV by Lown, as compared with ...
O N Soldatova, L A Balykova, L M Makarov, V N Komolyatova, S N Chuprova, O M Soldatov, T I Kornilova   +6 more
doaj  

Cardiac Arrhythmias and Antiarrhythmic Drugs: An Autophagic Perspective

Frontiers in Physiology, 2018
Degradation of cellular material by lysosomes is known as autophagy, and its main function is to maintain cellular homeostasis for growth, proliferation and survival of the cell.
Joanne J. A. van Bavel, Marc A. Vos, Marcel A. G. van der Heyden   +2 more
doaj   +1 more source