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4. Pharmacologic Therapy: Antiarrhythmic Drug Therapy.
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Current Treatment Options in Cardiovascular Medicine, 2006
The use of antiarrhythmic drugs can be challenging to physicians. They are effective in treating various types of arrhythmias, yet their potential to cause adverse events, in particularly proarrhythmia, can be intimidating. When the decision to use antiarrhythmic therapy has been made, physicians are confronted with several issues: choosing the right ...
Brian R, Triola, Peter R, Kowey
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The use of antiarrhythmic drugs can be challenging to physicians. They are effective in treating various types of arrhythmias, yet their potential to cause adverse events, in particularly proarrhythmia, can be intimidating. When the decision to use antiarrhythmic therapy has been made, physicians are confronted with several issues: choosing the right ...
Brian R, Triola, Peter R, Kowey
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Therapy with Antiarrhythmic Drugs
New England Journal of Medicine, 1978How much of what drug for whom?1 Good habits of mind are encouraged when the physician asks these questions before prescribing a drug.
P, Goldman, J A, Ingelfinger
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Pharmacogenetics of antiarrhythmic therapy
Expert Opinion on Pharmacotherapy, 2006Individuals vary widely in their responses to therapy with most drugs. Indeed, responses to antiarrhythmic drugs are so highly variable that study of the underlying mechanisms has elucidated important lessons for understanding variable responses to drug therapy in general. Variability in drug response may reflect variability in the relationship between
Dawood, Darbar, Dan M, Roden
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Atrial Fibrillation: Antiarrhythmic Therapy
Current Problems in Cardiology, 2014Atrial fibrillation is the most common cardiac arrhythmia and is associated with significant morbidity, mortality, and economic cost. Although the benefit of anticoagulation has been well described, control of the underlying rhythm disturbance can be achieved in various ways. Numerous therapeutic options exist and continue to be developed; however, the
Mitchell A, Psotka, Byron K, Lee
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Antiarrhythmic Therapy: Clinical Pharmacology Update
The Journal of Clinical Pharmacology, 1984Abstract: Currently available antiarrhythmic agents are limited by side effects and the potential for increasing arrhythmias. In addition, drug interactions, altered disposition of drug as a result of changes in protein binding or concomitant disease processes, active metabolites, and poorly defined therapeutic ranges with great interpatient ...
R L, Woosley, I, Cerskus, D M, Roden
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Current antiarrhythmic therapy overview
Cardiovascular Drugs and Therapy, 1990Cardiac arrhythmias are commonplace in the Western world and vary in their degree of seriousness from benign to life threatening. In general, arrhythmias may be managed in one of five ways: reassurance only, physical maneuvers, antiarrhythmic drugs, implantable electronic devices, and surgical or transvascular ablation.
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Advances in Antiarrhythmic Therapy
Veterinary Clinics of North America: Small Animal Practice, 1998The therapy of cardiac arrhythmias in small animals can be confusing and challenging. This article reviews the current concepts of cardiac rhythm, including impulse generation, automaticity, and conduction in normal and diseased cardiac tissues. The mechanisms of arrhythmogenesis (abnormal automaticity and triggered events) and automatic modulation of ...
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Pharmacoeconomic Considerations in Antiarrhythmic Therapy
PharmacoEconomics, 1992Recently, the Cardiac Arrhythmia Suppression Trial (CAST) has focused attention on the morbidity and mortality that may be associated with pharmacological antiarrhythmic therapies. While the severity and frequency of adverse effects vary among the available agents, it is uncertain whether initial therapy with one agent is preferable to that with ...
P J, Podrid, R J, Arnold, D J, Kaniecki
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