Results 161 to 170 of about 26,046 (277)

Understanding CPVT pathogenic mechanisms based on mutation location within RyR2: towards personalized medicine?

The Journal of Physiology, EarlyView.
Jean‐Pierre Benitah, Esther Zorio, Ana María Gómez   +2 more
wiley   +1 more source

Beta Blocker Toxicity at Therapeutic Doses: A Look Into Carvedilol Use in the Elderly

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Beta‐blocker toxicity does not occur only in overdose situations. In vulnerable populations such as children and the elderly, therapeutic doses may produce cumulative toxic effects similar to those seen in acute overdose. These patients require monitoring that extends beyond basic laboratory investigations to preempt cumulative toxicity.
Samuel Amo‐Tachie
wiley   +1 more source

Relevance of mexiletine in the era of evolving antiarrhythmic therapy of ventricular arrhythmias. [PDF]

Clin Res Cardiol
Alhourani N, Wolfes J, Könemann H, Ellermann C, Frommeyer G, Güner F, Lange PS, Reinke F, Köbe J, Eckardt L.   +9 more
europepmc   +1 more source

From Molecules to Machines: An Integrative Framework Linking Molecular Pathogenesis, Multi‐Factorial Risk, Risk Stratification, Clinical Management, and Artificial Intelligence in QT Prolongation and Sudden Cardiac Death

Clinical Cardiology, Volume 49, Issue 6, June 2026.
An integrative conceptual framework linking the five principal domains addressed in this review. Beginning at the molecular level, loss‐of‐function mutations in KCNQ1 and KCNH2 reduce outward repolarizing currents (IKs and IKr), while gain‐of‐function SCN5A mutations augment late inward sodium current (INa), establishing the genetic substrate for ...
Mojtaba Farjam, Mohammad Hosein Yazdanpanah, Narges Fereydouni   +2 more
wiley   +1 more source

T‐Cell Acute Lymphoblastic Leukemia in a Young Patient With Andersen–Tawil Syndrome Successfully and Safely Treated With Intensive Chemotherapy Including Potential Precipitating Drugs: A Case Report After 3.5 Years of Follow‐up

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Andersen–Tawil syndrome (ATS) is a rare, hereditary channelopathy characterized by periodic paralysis, cardiac arrhythmias, and sometimes developmental anomalies. No association with hematologic malignancies has previously been reported. We describe the case of a 27‐year‐old man with genetically confirmed Type 1 ATS who developed T‐cell acute ...
Ramy Rahmé, Paule Moussounda Bamba, Thi Thuy Duong Do, Anthony Behin, Estelle Gandjbakhch, Claude Gardin, Thorsten Braun   +6 more
wiley   +1 more source

Efficacy of Fixed Low‐Power Long‐Duration Radiofrequency Ablation of Ventricular Arrhythmias Originating From the Left Ventricular Summit

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
Efficacy and safety of a fixed low‐power, long‐duration radiofrequency catheter ablation of ventricular arrhythmias originating from the left ventricular summit. ABSTRACT Background Radiofrequency catheter ablation (RFCA) of ventricular arrhythmias originating from the left ventricular summit (LVS‐VAs) remains challenging.
Takuro Masuda, Koji Nakagawa, Satoshi Kawada, Tomofumi Mizuno, Akira Ueoka, Saori Asada, Masakazu Miyamoto, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Morita, Shinsuke Yuasa   +10 more
wiley   +1 more source

Sleep Apnea and Paroxysmal Atrial Fibrillation: Diurnal Patterning of Autonomic Dysfunction and Influence of CPAP Therapy

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
Autonomic dysfunction in sleep apnea shows diurnal variation, with stronger associations between SDB severity and HRV during wakefulness than sleep. CPAP therapy induces complex, state‐dependent changes in HRV, suggesting that daytime autonomic alterations may better reflect sustained cardiovascular risk in patients with paroxysmal atrial fibrillation.
Sepideh Khazaie, Lu Wang, Farhad Kaffashi, Ahana Sandhu, Mina K. Chung, Catherine M. Heinzinger, David R. Van Wagoner, Kenneth A. Loparo, Harneet K. Walia, James F. Bena, Reena Mehra   +10 more
wiley   +1 more source

Epicardial adipose tissue‐linked leukotriene and cytokine signalling pathways – novel targets for prevention of obesity‐ and diabetes‐linked ventricular arrhythmia

The Journal of Physiology, EarlyView.
Kelly A. Aromolaran, Ademuyiwa S. Aromolaran   +1 more
wiley   +1 more source

Efficacy and Safety of Catheter Ablation in Very Elderly Patients With Atrial Fibrillation: Short‐ To Mid‐Term Outcomes From a Multicenter Study

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
Patients aged ≥ 80 years with atrial fibrillation underwent catheter ablation. At 2 years, the recurrence‐free survival rate was 85.8% in paroxysmal AF and 63.6% in persistent AF (p = 0.024), and periprocedural complications occurred in 12.0%, including severe complications in 3.3%.
Takumi Tamura, Yoshihisa Naruse, Taro Narumi, Yuki Tokonami, Yasukazu Takazawa, Kazuki Ito, Yutaro Kaneko, Makoto Sano, Ryosuke Takeuchi, Natsuko Hosoya, Masahiro Muto, Ryuta Henmi, Ryo Sugiura, Keisuke Miyajima, Yuichiro Maekawa   +14 more
wiley   +1 more source

Interlesion Time as a Key Metric of Procedural Proficiency in Atrial Fibrillation Ablation: From Fellow to Attending

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
Attending EPs performed ablation with shorter ILT, which likely contributed to more efficient procedures and reduced overall ablation time. ABSTRACT Introduction Pulmonary vein isolation (PVI) is a cornerstone of atrial fibrillation (AF) ablation. Unlike balloon‐based or pulsed field ablation, radiofrequency ablation requires precise catheter control ...
Hitoshi Mori, Daisuke Kawano, Masataka Narita, Kazuhisa Matsumoto, Tsukasa Naganuma, Wataru Sasaki, Naomichi Tanaka, Kazuhiko Kuinose, Kei Matsumoto, Yoshifumi Ikeda, Kazuo Matsumoto, Ritsushi Kato   +11 more
wiley   +1 more source