Results 51 to 60 of about 1,809,047 (357)

Non-antibiotic effect of antibiotic [PDF]

Clinical Microbiology and Infection, 1996
In the present study, we demonstrated the efficacy of low-dose, long-term therapy with erythromycin and an erythromycin-related compound, roxithromycin, in patients with chronic lower respiratory tract disease including diffuse panbronchiolitis (DPB), and investigated the anti-inflammatory action of such drugs. Treatment significantly improved the mean
openaire   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Persisters show heritable phenotype and generate bacterial heterogeneity and noise in protein expression [PDF]

, 2007
Persisters are a small subpopulation of bacteria that survive a lethal concentration of antibiotic without antibiotic resistance genes. Isolation of persisters from normally dividing population is considered difficult due to their slow growth, low ...
Jaison Jacob
core   +2 more sources

Comparative transcriptomics of multidrug-resistant Acinetobacter baumannii in response to antibiotic treatments [PDF]

, 2018
Multidrug-resistant Acinetobacter baumannii, a major hospital-acquired pathogen, is a serious health threat and poses a great challenge to healthcare providers.
Chan, Ting-Fung, Fong-Chuen Loo, Jacky, Ip, Margaret, Lau, Terrence Chi-Kong, Lin, Xiao, Qin, Hao, Tsui, Stephen Kwok-Wing, Wai-Sing Lo, Norman, Yim, Aldrin Kay-Yuen   +8 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Carbapenem-resistant Acinetobacter baumannii carrier detection: a simple and efficient protocol

Microbiology Spectrum
Timely detection of carbapenem-resistant Acinetobacter baumannii (CRAB) carriers is essential to direct infection control measures. In this work, we aimed to develop a practical protocol to detect CRAB from screening samples. To choose a selective medium
Jonathan Lellouche, Alona Keren-Paz, Reut Rov, Reut Efrati Epchtien, Sammy Frenk, Amichay Hameir, Elizabeth Temkin, David Schwartz, Yehuda Carmeli   +8 more
doaj   +1 more source

Detection of Multi-drug Resistant \u3cem\u3eEscherichia coli\u3c/em\u3e in the Urban Waterways of Milwaukee, WI [PDF]

, 2015
Urban waterways represent a natural reservoir of antibiotic resistance which may provide a source of transferable genetic elements to human commensal bacteria and pathogens. The objective of this study was to evaluate antibiotic resistance of Escherichia
Ahuja, Neha H., DeNies, Maxwell S., Hristova, Krassimira R., Kappell, Anthony D., Ledeboer, Nathan A., Newton, Ryan J.   +5 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes

Nature Communications
Microbial Ni2+ homeostasis underpins the virulence of several clinical pathogens. Ni2+ is an essential cofactor in urease and [NiFe]-hydrogenases involved in colonization and persistence.
David Sychantha, Xuefei Chen, Kalinka Koteva, Gerd Prehna, Gerard D. Wright   +4 more
doaj   +1 more source

Correction to: Managing pollution from antibiotics manufacturing: charting actors, incentives and disincentives

Environmental Health, 2019
Following publication of the original article [1], the author explained that there are multiple errors in the original ...
Niels Nijsingh, Christian Munthe, D. G. Joakim Larsson   +2 more
doaj   +1 more source