Results 61 to 70 of about 1,197,282 (304)

New antibiotics for antibiotic-resistant bacteria [PDF]

F1000 Biology Reports, 2009
The need for new antibiotics to effectively treat antibiotic-resistant infections remains unfulfilled. Despite the well-publicised concern over this issue, only two novel antibiotic classes have been introduced in the past 20 years alongside several new agents of existing classes.
Stubbings, William, Labischinski, Harald
openaire   +2 more sources

Antibiotic prescribing on two medical wards at St Luke’s Hospital : what scope for improvement? [PDF]

, 1996
Antibiotics are frequently prescribed drugs and form a significant part of the hospital budget. The literature suggests that prescribing is not without problems and may need constant review. We have no data relating to our hospital.
Fenech, Frederick F., Ebejer, Martin J., Schiavone, M., Vella, Patricia   +3 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Genotyping-Guided Discovery of Persiamycin A From Sponge-Associated Halophilic Streptomonospora sp. PA3

Frontiers in Microbiology, 2020
Microbial natural products have been a cornerstone of the pharmaceutical industry, but the supply of novel bioactive secondary metabolites has diminished due to extensive exploration of the most easily accessible sources, namely terrestrial Streptomyces ...
Soheila Matroodi, Soheila Matroodi, Vilja Siitonen, Bikash Baral, Keith Yamada, Amir Akhgari, Mikko Metsä-Ketelä   +6 more
doaj   +1 more source

Environmental Spread of Antibiotic Resistance

, 2021
Antibiotic resistance represents a global health concern. Soil, water, livestock and plant foods are directly or indirectly exposed to antibiotics due to their agricultural use or contamination.
Bosul Lee, Nicholas Skandalis, Dimitris Papafotis, Marlène Maeusli, Brian Luna, Ioannis Theologidis, Sarah Miller   +6 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Evaluation of combination therapy duration for endocarditis secondary to Enterobacterales

Antimicrobial Agents and Chemotherapy
Combination antimicrobial treatment for endocarditis secondary to Enterobacterales may be associated with clinical benefits, but this benefit comes with an increased risk of adverse drug reactions (ADRs).
Sunish Shah, Jake Smith, Brandon J. Smith, Ryan K. Shields   +3 more
doaj   +1 more source

Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis

eLife, 2019
Bacterial metabolism is fundamental to survival and pathogenesis. We explore how Mycobacterium tuberculosis utilises amino acids as nitrogen sources, using a combination of bacterial physiology and stable isotope tracing coupled to mass spectrometry ...
Aleksandra Agapova, Agnese Serafini, Michael Petridis, Debbie M Hunt, Acely Garza-Garcia, Charles D Sohaskey, Luiz Pedro Sório de Carvalho   +6 more
doaj   +1 more source

Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli [PDF]

, 2011
This work is also partially supported by BBSRC and the Scottish Funding Council (through SULSA)Antibiotic-resistant bacteria, particularly Gram negative species, present significant health care challenges.
H. Lou, M. Chen, Susan S Black, Beis Konstantinos, Bayley Hagan, Matteo Ceccarelli, Beis, Konstantinos, Bushell, SR, Ian R Booth, Victoria A. Bamford, A. Low, Alison S Low, Bamford Victoria A., I. R. Booth, Ceccarelli Matteo, Bushell, Simon R, Ceccarelli, Matteo, Ceccarelli, M, V. A. Bamford, J. H. Naismith, James H. Naismith, James H Naismith, Booth, Ian R, Bamford, Victoria A., Naismith James H., Lou Hubing, Booth Ian R., Low, AS, Black, Susan S, Low, Alison S, Naismith, James H, Tivadar Mach, S. S. Black, Naismith, JH, H. Bayley, Low, Alison S., Mach, T, Black, Susan S., Chen, M, Bushell Simon R., Simon R. Bushell, Susan S. Black, Low Alison S., Mach Tivadar, Beis, K, Hagan Bayley, Bushell, Simon R., Min Chen, Bamford, Victoria A, Bamford, VA, K. Beis, Lou, H, Ian R. Booth, S. R. Bushell, Mach, Tivadar, Konstantinos Beis, Lou, Hubing, Booth, IR, Black Susan S., Bayley, Hagan, Alison S. Low, Naismith, James H., T. Mach, Chen Min, Booth, Ian R., Simon R Bushell, Bayley, H, Chen, Min, Victoria A Bamford, Black, SS, Hubing Lou   +70 more
core   +1 more source