Results 51 to 60 of about 1,082,887 (313)

Carbapenem-resistant Acinetobacter baumannii carrier detection: a simple and efficient protocol

Microbiology Spectrum
Timely detection of carbapenem-resistant Acinetobacter baumannii (CRAB) carriers is essential to direct infection control measures. In this work, we aimed to develop a practical protocol to detect CRAB from screening samples. To choose a selective medium
Jonathan Lellouche, Alona Keren-Paz, Reut Rov, Reut Efrati Epchtien, Sammy Frenk, Amichay Hameir, Elizabeth Temkin, David Schwartz, Yehuda Carmeli   +8 more
doaj   +1 more source

Managing pollution from antibiotics manufacturing: charting actors, incentives and disincentives

Environmental Health, 2019
Background Emissions of high concentrations of antibiotics from manufacturing sites select for resistant bacteria and may contribute to the emergence of new forms of resistance in pathogens. Many scientists, industry, policy makers and other stakeholders
Niels Nijsingh, Christian Munthe, D. G. Joakim Larsson   +2 more
doaj   +1 more source

Antibiotic resistance in the environment, with particular reference to MRSA [PDF]

, 2008
The introduction of β-lactam antibiotics (penicillins and cephalosporins) in the 1940s and 1950s probably represents the most dramatic event in the battle against infection in human medicine.
William Gaze, Gaze, William H., Hawkey, Peter, Peter Hawkey, Hawkey, P. M., O'Neill, Colette, O'Neill, C, Colette O'Neill, Elizabeth Wellington, Gaze, W, Wellington, E, Wellington, Elizabeth, Wellington, E. M. H., Gaze, William   +13 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes

Nature Communications
Microbial Ni2+ homeostasis underpins the virulence of several clinical pathogens. Ni2+ is an essential cofactor in urease and [NiFe]-hydrogenases involved in colonization and persistence.
David Sychantha, Xuefei Chen, Kalinka Koteva, Gerd Prehna, Gerard D. Wright   +4 more
doaj   +1 more source

Correction to: Managing pollution from antibiotics manufacturing: charting actors, incentives and disincentives

Environmental Health, 2019
Following publication of the original article [1], the author explained that there are multiple errors in the original ...
Niels Nijsingh, Christian Munthe, D. G. Joakim Larsson   +2 more
doaj   +1 more source

Colistin-degrading proteases confer collective resistance to microbial communities during polymicrobial infections

Microbiome, 2022
Background The increasing prevalence of resistance against the last-resort antibiotic colistin is a significant threat to global public health. Here, we discovered a novel colistin resistance mechanism via enzymatic inactivation of the drug and proposed ...
Do-Hoon Lee, Ju-Hee Cha, Dae-Wi Kim, Kihyun Lee, Yong-Seok Kim, Hyo-Young Oh, You-Hee Cho, Chang-Jun Cha   +7 more
doaj   +1 more source

Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments [PDF]

, 2019
Discharge of treated sewage leads to release of antibiotic resistant bacteria, resistance genes and antibiotic residues to the environment. However, it is unclear whether increased abundance of antibiotic resistance genes in sewage and sewage-impacted ...
Parnanen, Katariina, Larsson, D. G. Joakim, Katariina Pärnänen, Karkman, Antti, Larsson, D. G. Joakim,, Pärnänen, K, Antti Karkman, D. G. Joakim Larsson, Karkman, Antti,   +8 more
core   +1 more source

Classification of all 94,249 International Classification of Diseases, 10^th Edition, Clinical Modification diagnosis codes as chronic, antibiotic-appropriate, potentially antibiotic-appropriate, and non-antibiotic-appropriate.

, 2023
Classification of all 94,249 International Classification of Diseases, 10th Edition, Clinical Modification diagnosis codes as chronic, antibiotic-appropriate, potentially antibiotic-appropriate, and non-antibiotic-appropriate.
Adriana Guzman (16698843), Mark W. Friedberg (6696116), Tiffany Brown (10805423), Ji Young Lee (235181), Kao-Ping Chua (12466431), Michael A. Fischer (12354576), Jeffrey A. Linder (10805429)   +6 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source