Results 51 to 60 of about 1,234,048 (260)

Antibiotic prescribing on two medical wards at St Luke’s Hospital : what scope for improvement? [PDF]

, 1996
Antibiotics are frequently prescribed drugs and form a significant part of the hospital budget. The literature suggests that prescribing is not without problems and may need constant review. We have no data relating to our hospital.
Fenech, Frederick F., Ebejer, Martin J., Schiavone, M., Vella, Patricia   +3 more
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Varieties of biosocial imagination : reframing responses to climate change and antibiotic resistance [PDF]

, 2013
The authors present climate change and antibiotic resistance as emergent biosocial phenomena—ongoing products of massively multiple interactions among human lifestyles and broader life processes.
Lee, Nick, Motzkau, Johanna
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli [PDF]

, 2011
This work is also partially supported by BBSRC and the Scottish Funding Council (through SULSA)Antibiotic-resistant bacteria, particularly Gram negative species, present significant health care challenges.
H. Lou, M. Chen, Susan S Black, Beis Konstantinos, Bayley Hagan, Matteo Ceccarelli, Beis, Konstantinos, Ian R Booth, Victoria A. Bamford, A. Low, Alison S Low, Bamford Victoria A., I. R. Booth, Ceccarelli Matteo, Bushell, Simon R, Ceccarelli, Matteo, V. A. Bamford, J. H. Naismith, James H. Naismith, James H Naismith, Booth, Ian R, Bamford, Victoria A., Naismith James H., Lou Hubing, Booth Ian R., Black, Susan S, Low, Alison S, Naismith, James H, Tivadar Mach, S. S. Black, H. Bayley, Low, Alison S., Black, Susan S., Bushell Simon R., Simon R. Bushell, Susan S. Black, Low Alison S., Mach Tivadar, Hagan Bayley, Bushell, Simon R., Min Chen, Bamford, Victoria A, K. Beis, Ian R. Booth, S. R. Bushell, Mach, Tivadar, Konstantinos Beis, Lou, Hubing, Black Susan S., Bayley, Hagan, Alison S. Low, Naismith, James H., T. Mach, Chen Min, Booth, Ian R., Simon R Bushell, Chen, Min, Victoria A Bamford, Hubing Lou   +58 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Impact and Sustainability of Antibiotic Stewardship on Antibiotic Prescribing in Visceral Surgery

Antibiotics, 2021
Background: Antibiotic stewardship (AS) ward rounds are a core element in clinical care for surgical patients. Therefore, we aimed to analyze the impact of surgical AS ward rounds on antibiotic prescribing, and the sustainability of the effect after the ...
Magdalena Monika Gruber, Alexandra Weber, Jette Jung, Jens Werner, Rika Draenert   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Carbapenem-resistant Acinetobacter baumannii carrier detection: a simple and efficient protocol

Microbiology Spectrum
Timely detection of carbapenem-resistant Acinetobacter baumannii (CRAB) carriers is essential to direct infection control measures. In this work, we aimed to develop a practical protocol to detect CRAB from screening samples. To choose a selective medium
Jonathan Lellouche, Alona Keren-Paz, Reut Rov, Reut Efrati Epchtien, Sammy Frenk, Amichay Hameir, Elizabeth Temkin, David Schwartz, Yehuda Carmeli   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source