Results 71 to 80 of about 1,082,887 (313)
Nature CommunicationsOur understanding of the rapid adaptation of bacteria to resist novel drugs is growing beyond known mechanisms such as mobile genetic elements and mutation selection.
Jacob E. Choby +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Microbiome, 2017 Background Metallo-β-lactamases are bacterial enzymes that provide resistance to carbapenems, the most potent class of antibiotics. These enzymes are commonly encoded on mobile genetic elements, which, together with their broad substrate spectrum and ...
Fanny Berglund +7 more
doaj +1 more source
ANTIBIOTICS and RESISTANCE to ANTIBIOTICS
, 2023 Antibiotics are natural or synthetic molecules that can inhibit the growth of bacteria (bacteriostatic) or kill some bacteria (bactericidal) (Gamboa et al, 2022). They exert a specific effect on certain structures or functions of the microorganism.
openaire +1 more source
Improvement in Timing of Antibiotic Administration by Using a Prophylactic Antibiotic Record Form
, 2011 Background/Purpose: To evaluate the effect of a form recording the timing of prophylactic antibiotic administration, antibiotics used, and treatment duration on the proper use of prophylactic antibiotics in patients undergoing four types of operations ...
PAN, SUNG-CHING;SUN, HSIN-YUN;LIN, JOU-WEI;LIN, JING;LAI, TAI-SHUAN;CHANG, SHAN-CHWEN +1 more
core +1 more source
Cluster randomised trial in the General Practice Research Database: 1. Electronic decision support to reduce antibiotic prescribing in primary care (eCRT study) [PDF]
, 2011 Background: the purpose of this research is to develop and evaluate methods for conducting cluster randomised trials in a primary care database that contains electronic patient records for large numbers of family practices.
Little Paul +47 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Monopoly Pricing of an Antibiotic Subject to Bacterial Resistance [PDF]
We develop a dynamic bio-economic model of bacterial resistance and disease transmission in which we characterize the pricing policy of a monopolist who is protected by a patent.
Markus Herrmann
core
Antibiotic and Modulation of Microbiota A New Paradigm?
, 2018 Recently new insights on gut microbiota have revolutionized many concepts of the modern medicine. The alteration of microbiota, which is called dysbiosis, has been associated with an expanding list of diseases and conditions.
Antonio Gasbarrini +5 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source