Results 81 to 90 of about 1,197,282 (304)

Classification of all 94,249 International Classification of Diseases, 10^th Edition, Clinical Modification diagnosis codes as chronic, antibiotic-appropriate, potentially antibiotic-appropriate, and non-antibiotic-appropriate.

, 2023
Classification of all 94,249 International Classification of Diseases, 10th Edition, Clinical Modification diagnosis codes as chronic, antibiotic-appropriate, potentially antibiotic-appropriate, and non-antibiotic-appropriate.
Adriana Guzman (16698843), Mark W. Friedberg (6696116), Tiffany Brown (10805423), Ji Young Lee (235181), Kao-Ping Chua (12466431), Michael A. Fischer (12354576), Jeffrey A. Linder (10805429)   +6 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin [PDF]

, 2012
There is a continuing need to discover new bioactive natural products, such as antibiotics, in genetically-amenable micro-organisms. We observed that the enteric insect pathogen, Serratia marcescens Db10, produced a diffusible compound that inhibited the
Coulthurst Sarah J., Challis Gregory L., Stanley-Wall, Nicola R; id_orcid, Gregory L Challis, Gerc, Amy J., Amy J. Gerc, Gerc Amy J., Nicola R Stanley-Wall, Gregory L. Challis (136140), Song Lijiang, Coulthurst, Sarah J; id_orcid, Sarah J. Coulthurst, Lijiang Song (136135), Lijiang Song, Stanley-Wall, Nicola R., Stanley-Wall Nicola R., Coulthurst, Sarah J., Nicola R. Stanley-wall, Challis, Gregory L., Challis, Gregory L, Amy J Gerc, Sarah J. Coulthurst (136148), Song, Lijiang, Gerc, Amy J, Amy J. Gerc, Amy J. Gerc (136131), Nicola R. Stanley-Wall (136144), Sarah J Coulthurst, Gregory L. Challis   +28 more
core   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Cluster randomised trial in the General Practice Research Database: 1. Electronic decision support to reduce antibiotic prescribing in primary care (eCRT study) [PDF]

, 2011
Background: the purpose of this research is to develop and evaluate methods for conducting cluster randomised trials in a primary care database that contains electronic patient records for large numbers of family practices.
Little Paul, Van Staa, Tjeerd; id_orcid, Ashworth, Maek, Delaney, Brendan, van Staa, Tjeerd, Gulliford Martin C, Moore Michael V, Judith Charlton, Paul Little, Gerard McCann, Gulliford, Martin C., Charlton, Judith, Little, Paul, Grieve, Andrew P, Ashworth Mark, Ashworth, Mark, Martin C Gulliford, Grieve Andrew P, Grieve, Andrew P., Van Staa, Tjeerd P., Dregan Alex, McCann, Gerard, Charlton Judith, electronic Cluster Randomised Trial Research Team eCRT Research, Taweel, Adel, Moore, Michael, Andrew P Grieve, Lucy Yardley, Mark Ashworth, Michael V Moore, Dregan, Alex; id_orcid, McCann Gerard, Tjeerd van Staa, Dregan, Alex, Yardley, Lucy, McDermott, Lisa, van Staa Tjeerd, null null, Electronic Cluster Randomised Trial Research Team eCRT Research Team, Wolfe, Charles, Lisa McDermott, Yardley Lucy, Gulliford, Martin C, Rudd, Anthony, Moore, Michael V, McDermott Lisa, Alex Dregan, Moore, Michael V.   +47 more
core   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Seasonal variations in antibiotic resistance gene transport in the Almendares River, Havana, Cuba [PDF]

, 2012
Numerous studies have quantified antibiotic resistance genes (ARG) in rivers and streams around the world, and significant relationships have been shown that relate different pollutant outputs and increased local ARG levels.
Olivares-Rieumont, Susana, Knapp, Charles, Lima, Lazaro, Emma eBowen, David eWerner, Lazaro Lima, David W. Graham, Werner, David, Charles W. Knapp, Susana Olivares-Rieumont, Emma Bowen, Charles W Knapp, Lazaro eLima, Bowen, Emma, David Werner, Graham, David W., David W eGraham, Susana eOlivares-Rieumont   +17 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

ESBL- and pAmpC-producing Enterobacterales from Swedish dogs and cats 2017–2021: a retrospective study

Acta Veterinaria Scandinavica
Background Antibiotic resistant bacteria are a threat to both human and animal health. Of special concern are resistance mechanisms that are transmissible between bacteria, such as extended-spectrum beta-lactamases (ESBL) and plasmid-mediated AmpC (pAmpC)
Anna Bonnevie, Mattias Myrenås, Oskar Nilsson   +2 more
doaj   +1 more source

A Bayesian Belief Network to Infer Incentive Mechanisms to Reduce Antibiotic Use in Livestock Production [PDF]

Efficient policy intervention to reduce antibiotic use in livestock production requires knowledge about the rationale underlying antibiotic usage. Animal health status and management quality are considered the two most important factors that influence ...
Bergevoet, Ron H.M., Ge, Lan, Valeeva, Natasha I., Van Asseldonk, Marcel A.P.M., Hennen, Wil   +4 more
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