Results 101 to 110 of about 1,082,887 (313)
, 2022 Microbial pathogenesis is considered one of the most critical health challenges worldwide. Although several antibiotics have been procured and used, the microbes often manage to escape and become resistant to antibiotics.
Jaydeep Bhattacharya (6755114) +6 more
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Nature CommunicationsPlasmids carrying antibiotic resistance genes (ARG) are the main mechanism of resistance dissemination in Enterobacterales. However, the fitness-resistance trade-off may result in their elimination.
Pengdbamba Dieudonné Zongo +7 more
doaj +1 more source
Patient Knowledge and Antibiotic Abuse: Evidence from an Audit Study in China [PDF]
We ask how patient knowledge of appropriate antibiotic usage affects both physicians prescribing behavior and the physician-patient relationship. We conduct an audit study in which a pair of simulated patients with identical flu-like complaints visits ...
Wei Zhang, Janet Currie, Wanchuan Lin
core
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Combating Antibiotic Resistant Bacteria
, 2014 Effectively combating antibiotic resistance requires a strategy of continual surveillance and analysis of resistant bacteria and an accelerated research and development (R&D) cycle for new antibiotics.
PCAST Antibiotic Resistance Working Group +2 more
core
An evaluation of antimicrobial stewardship in community pharmacy [PDF]
, 2016 This study investigated several aspects of antimicrobial stewardship by gathering information from community pharmacists and members of the public. The aim was to identify how community pharmacists implement antimicrobial stewardship guidelines and ...
Mellor, Callan, Hancock, Laura Jade
core +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Critical Care Clinics, 1998 Antibiotic resistance is an increasing problem in many parts of the world. Antibiotic resistance has been associated with the use of some antibiotics but not with others. Due to the overuse of antibiotics with a high resistance potential, there has been an increase of resistance with certain bacteria, e.g., Staphylococcus aureus, Pseudomonas aeruginosa
openaire +3 more sources