Results 91 to 100 of about 1,082,887 (313)

Genomic and phenotypic characterization of six multidrug-resistant Acinetobacter pittii isolates

Scientific Reports
The Acinetobacter calcoaceticus-baumannii complex is a significant cause of nosocomial infections. While A. baumannii is the most common and clinically significant member globally, recent studies suggest that A.
Nadya Rakovitsky, Mor Lurie-Weinberger, Alona Keren-Paz, Yehuda Carmeli   +3 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Improving antibiotic stewardship skills through interdisciplinary online education: a multicenter teaching intervention for physicians and pharmacists

BMC Medical Education
Background Effective antibiotic prescribing is a core competency for physicians and pharmacists in combating antimicrobial resistance. Despite this, many healthcare professionals report limited confidence in applying antibiotic stewardship principles in ...
Till Koch, Johannes Jochum, Annika van der Linde, Friederike Jahn, Anika Neubert, Evelyn Kramme, Anette Friedrichs   +6 more
doaj   +1 more source

Optimizing COVID-19 surveillance in long-term care facilities: a modelling study

BMC Medicine, 2020
Background Long-term care facilities (LTCFs) are vulnerable to outbreaks of coronavirus disease 2019 (COVID-19). Timely epidemiological surveillance is essential for outbreak response, but is complicated by a high proportion of silent (non-symptomatic ...
David R. M. Smith, Audrey Duval, Koen B. Pouwels, Didier Guillemot, Jérôme Fernandes, Bich-Tram Huynh, Laura Temime, Lulla Opatowski, on behalf of the AP-HP/Universities/Inserm COVID-19 research collaboration   +8 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Comparison of antibiotic consumption in the three internal medicine departments

, 2014
Because of the excessive usage of antibiotics, development of resistant bacteria emerges and therefore monitoring of antibiotic resistance and consumption is essential.
Kristínardóttir, Ester
core  

Evaluating an audit and feedback intervention for reducing antibiotic prescribing behaviour in general dental practice (the RAPiD trial):a partial factorial cluster randomised trial protocol [PDF]

, 2014
Background: Antibiotic prescribing in dentistry accounts for 9% of total antibiotic prescriptions in Scottish primary care. The Scottish Dental Clinical Effectiveness Programme (SDCEP) published guidance in April 2008 (2nd edition, August 2011) for Drug ...
Ramsay, Craig R, Clarkson, Jan E.; id_orcid, Maria Prior, Elders, Andrew, Treweek, S, Elouafkaoui, P., Prior, M, Jan E Clarkson, Ramsay, CR, Translation Research in a Dental Setting (TRiaDS) Research Metho, Rumana Newlands, Ramsay, Craig, Bonetti, D, Stirling, D, Ramsay, C. R., Michie, S, Clarkson, J. E., Francis, J., Clarkson, Jan E, Vale, L, Elders, A., Clarkson, JE, null null, Pitts, N, Walker, A, Duncan, E. M., Clarkson, Jan, Francis, JJ, Prior, M., Grimshaw, JM, Young, Linda, Andrew Elders, Duncan, Eilidh M., Duncan, Eilidh, Black, I, Elders, A, Newlands, R., Duncan, EM, Linda Young, Young, L., Duncan, Eilidh M, Eldridge, S, Young, L, Torgerson, C, Ramsay, Craig R., Tilley, C, Translation Research in a Dental Setting (TRiaDS) Research Methodology Group, Newlands, R, Eilidh M Duncan, Paula Elouafkaoui, Elouafkaoui, Paula, Craig R Ramsay, Newlands, Rumana, Elouafkaoui, P, Prior, Maria, McKee, L   +55 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Characterization of Enterobacterales growing on selective CPE screening plates with a focus on non-carbapenemase-producing strains

Microbiology Spectrum
Carbapenem-resistant Enterobacterales (CRE) are divided into two distinct groups: carbapenemase-producing (CPE) and non-carbapenemase-producing (non-CPE).
Reut Efrati Epchtien, Elizabeth Temkin, Mor N. Lurie-Weinberger, Ophir Kastel, Alona Keren-Paz, David Schwartz, Yehuda Carmeli   +6 more
doaj   +1 more source

Are antibiotics naturally antibiotics?

Journal of Industrial Microbiology & Biotechnology, 2006
Antibiotics have been used for more than 50 years and are the cornerstone of infectious disease treatment; in addition, these low-molecular-weight bioactive compounds have been applied to many other therapeutic purposes. However, there is almost no information on the evolutionary biology or ecology of naturally occurring low-molecular-weight compounds.
openaire   +2 more sources