Results 91 to 100 of about 1,829,235 (358)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Genomic and phenotypic characterization of six multidrug-resistant Acinetobacter pittii isolates

Scientific Reports
The Acinetobacter calcoaceticus-baumannii complex is a significant cause of nosocomial infections. While A. baumannii is the most common and clinically significant member globally, recent studies suggest that A.
Nadya Rakovitsky, Mor Lurie-Weinberger, Alona Keren-Paz, Yehuda Carmeli   +3 more
doaj   +1 more source

Diversity of mucoid to non-mucoid switch among carbapenemase-producing Klebsiella pneumoniae

BMC Microbiology, 2020
Background Klebsiella pneumoniae is a leading cause of intractable hospital-acquired multidrug-resistant infections and carbapenemase-producing K. pneumoniae (CPKp) are particularly feared.
Adriana Chiarelli, Nicolas Cabanel, Isabelle Rosinski-Chupin, Pengdbamba Dieudonné Zongo, Thierry Naas, Rémy A. Bonnin, Philippe Glaser   +6 more
doaj   +1 more source

Nursing Home Infection Control Program Characteristics, CMS Citations, and Implementation of Antibiotic Stewardship Policies: A National Study. [PDF]

, 2018
Recently, the Centers for Medicare & Medicaid Services (CMS) final rule required that nursing homes (NHs) develop an infection control program that includes an antibiotic stewardship component and employs a trained infection preventionist (IP).
Agarwal, Mansi, Dick, Andrew W., Herzig, Carolyn T.A., Pogorzelska-Maziarz, Monika, Stone, Patricia W.   +4 more
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Improving antibiotic stewardship skills through interdisciplinary online education: a multicenter teaching intervention for physicians and pharmacists

BMC Medical Education
Background Effective antibiotic prescribing is a core competency for physicians and pharmacists in combating antimicrobial resistance. Despite this, many healthcare professionals report limited confidence in applying antibiotic stewardship principles in ...
Till Koch, Johannes Jochum, Annika van der Linde, Friederike Jahn, Anika Neubert, Evelyn Kramme, Anette Friedrichs   +6 more
doaj   +1 more source

Advancing Pediatric Antibacterial Drug Development: A Critical Need to Reinvent our Approach. [PDF]

, 2019
The Clinical Trials Transformation Initiative convened with several groups in the pediatric antibacterial drug development community with the goal of identifying challenges and recommending ways to improve current practice.
Bradley, John, Clinical Trials Transformation Initiative’s Pediatric Antibiotic Drug Development Program, Nambiar, Sumathi, Noel, Gary J   +3 more
core   +1 more source

Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis [PDF]

, 2018
Background: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging.
Abu Sin, Muna, Andrasevic, Arjana Tambic, Aracil, Belen, Asensio, Angel, Billstrom, Hanna, Borg, Michael A., Budimir, Ana, Burns, Karen, Canica, Manuela, Cassini, Alessandro, Catry, Boudewijn, Cecchini, Michele, Coignard, Bruno, Colomb-Cotinat, Melanie, Daikos, George L., de Greeff, Sabine C., Deptula, Aleksander, Devleesschauwer, Brecht, Dobreva, Elina Georgieva, Dsstat, Patrizio Pezzotti, Dumpis, Uga, Eckmanns, Tim, Elstrom, Petter, Fernandes, Paulo Andre, Gagliotti, Carlo, Gikas, Achilleas, Guolaugsson, Olafur, Hajdu, Agnes, Haller, Sebastian, Hogberg, Liselotte Diaz, Hopkins, Susan, Hoxha, Ana, Hryniewicz, Waleria, Ivanov, Ivan Nikolaev, Ivanova, Marina, Jalava, Jari, Johnson, Alan, Klavs, Irena, Koek, Mayke B. G., Kolman, Jana, Kontopidou, Flora, Korosec, Ales, Kretzschmar, Mirjam E., Kristinsson, Karl G., Larsson, Sofie, Latour, Katrien, Litvova, Slavka, Liuimiene, Agne, Lyytikainen, Outi, Manageiro, Vera, Martin, Pille, Mertens, Karl, Monen, Jos C. M., Monnet, Dominique L., Murchan, Stephen, Nogueira, Paulo Jorge, Oliveira, Tiago Cravo, Olsen, Stefan Schytte, Ouakrim, Driss Ait, Paphitou, Niki, Perez-Vazquez, Maria, Perrin, Monique, Plachouras, Diamantis, Popescu, Gabriel Adrian, Quattrocchi, Annalisa, Reilly, Jacqui S., Schreterova, Eva, Serban, Roxana Ioana, Simonsen, Gunnar Skov, Sonksen, Ute Wolff, Soprek, Silvija, Stefkovicova, Maria, Strauss, Reinhild, Struelens, Marc J., Struyf, Thomas, Suetens, Carl, Toth, Akos, Tsiodras, Sotirios, Zabicka, Dorota, Zemlickova, Helena   +79 more
core   +6 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

ESBL- and pAmpC-producing Enterobacterales from Swedish dogs and cats 2017–2021: a retrospective study

Acta Veterinaria Scandinavica
Background Antibiotic resistant bacteria are a threat to both human and animal health. Of special concern are resistance mechanisms that are transmissible between bacteria, such as extended-spectrum beta-lactamases (ESBL) and plasmid-mediated AmpC (pAmpC)
Anna Bonnevie, Mattias Myrenås, Oskar Nilsson   +2 more
doaj   +1 more source