Results 101 to 110 of about 253,773 (311)

Evolution of the streptomycin and viomycin biosynthetic clusters and resistance genes [PDF]

The distribution of the streptomycin (strA) and viomycin (vph) resistance genes was examined in Streptomyces isolates. It was hypothesised that non-antibiotic producers that are niche competitors with producers will need to possess resistance to the ...
Laskaris, Paris
core  

Involvement of hpap2 and dgkA Genes in Colistin Resistance Mediated by mcr Determinants

, 2020
Plasmid-mediated colistin resistance (mcr) determinants are challenging the efficacy of polymyxins against Gram-negative pathogens. Among 10 mcr genes described so far, the major determinants mcr-1 and mcr-3 are found closely linked to hpap2 or dgkA ...
Alberto Quesada, María Ugarte-Ruiz, Marta Hernández, Pedro Miguela-Villoldo, Lucas Domínguez, David Rodríguez-Lázaro, Alejandro Gallardo   +6 more
core   +1 more source

Functional metagenomic analysis reveals rivers are a reservoir for diverse antibiotic resistance genes [PDF]

, 2014
The environment harbours a significant diversity of uncultured bacteria and a potential source of novel and extant resistance genes which may recombine with clinically important bacteria disseminated into environmental reservoirs.
Hawkey, PM, Zhang, Lihong, Wellington, E M, Wellington, EM, Gaze, W.H., Gaze, WH, Amos, G C A, Gaze, William H., Hawkey, Peter, Hawkey, P. M., Amos, GCA, Wellington, E.M., Hawkey, P.M., Hawkey, P M, Amos, G.C.A., Zhang, L., Zhang, L, Wellington, E. M. H., Amos, Gregory C. A., Gaze, W H   +19 more
core   +1 more source

Screening of Antibiotic and Virulence Genes from Whole Genome Sequenced Cronobacter sakazakii Isolated from Food and Milk-Producing Environments

, 2023
The objective of this study was to use whole-genome sequencing (WGS) to screen for genes encoding for antibiotic resistance, fitness and virulence in Cronobacter sakazakii strains that had been isolated from food and powdered-milk-producing environments.
Julio Parra-Flores, Stephen Forsythe, Beatriz Daza-Prieto, Ondrej Holý, Ricardo Rodríguez-Martínez, Ariadnna Cruz-Córdova, Juan Xicohtencatl-Cortes, Werner Ruppitsch, Jaroslav Bzdil, Sergio Acuña, Adriana Cabal-Rosel   +10 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Antibiotic-resistance and virulence-related genes in commercially bottled natural mineral waters

BMC Microbiology
Background To date, the presence of antibiotics resistant genes (ARGs) and virulence-related genes (VRGs) has been evidenced in several surface waters, including natural surface water and wastewater, as well as drinking water.
Giulia Radocchia, Francesca Brunetti, Massimiliano Marazzato, Daniela Scribano, Lucia Nencioni, Anna Teresa Palamara, Serena Schippa, Fabrizio Pantanella   +7 more
doaj   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Novel determinants of antibiotic resistance : identification of mutated loci in highly methicillin-resistant subpopulations of methicillin-resistant Staphylococcus aureus

, 2014
This work was supported by a grant from the U.S. Public Health Service 2 RO1 AI457838-14 and by grant UL1 TR000043-07S1 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) Clinical and Translational ...
Kim, Choonkeun, Hermínia de Lencastre, Matthew T. J. Holden, Holden, Matthew T J, María Pardos de la Gándara, Tomasz, Alexander, Parkhill, Julian, de Lencastre, Hermínia, Alexander Tomasz, Stephen D. Bentley, Janina Dordel, Dordel, Janina, Pardos de la Gándara, María, Chung, Marilyn, Bentley, Stephen D, Marilyn Chung, Choonkeun Kim, Julian Parkhill   +17 more
core   +1 more source

Microarray-based detection of 90 antibiotic resistance genes of gram-positive bacteria [PDF]

, 2005
A disposable microarray was developed for detection of up to 90 antibiotic resistance genes in gram-positive bacteria by hybridization. Each antibiotic resistance gene is represented by two specific oligonucleotides chosen from consensus sequences of ...
Slickers, Peter, Vorlet-Fawer, Lorianne, Frey, Joachim, Ehricht, Ralf, Kuhnert, Peter, Perreten, Vincent   +5 more
core   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source