Results 251 to 260 of about 253,773 (311)

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Shifts in the Lung Microbiota and Antibiotic Resistance Genes Occur With Aging in Patients With Lower Respiratory Tract Infections. [PDF]

Biomed Res Int
Chen X, Dong T, Wu D, Pan Q, Wei J, Liang G, Lin Z.   +6 more
europepmc   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Captive breeding of specialty animals represents an overlooked yet critical reservoir for spreading antibiotic resistance genes. [PDF]

ISME J
Xi J, Tao H, Zhang Z, Lian B, Sun W, Zhang Y, Bu S, Yang X, Qian X.   +8 more
europepmc   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

The transferable resistome of biosolids-plasmid sequencing reveals carriage of clinically relevant antibiotic resistance genes. [PDF]

mBio
Hauschild K, Suzuki M, Wolters B, Tokuda M, Yamazaki R, Masumoto M, Moriuchi R, Dohra H, Bunk B, Spröer C, Shintani M, Smalla K.   +11 more
europepmc   +1 more source

Molecular characterization of virulence and antibiotic resistance genes in Klebsiella pneumoniae isolated from sputum samples at a tertiary hospital in Ethiopia. [PDF]

Sci Rep
Abebe AA, Birhanu AG, Tessema TS.
europepmc   +1 more source

Molecular detection of antibiotic resistance genes in Staphylococcus aureus isolated from poultry farms of Kathmandu Valley, Nepal. [PDF]

BMC Microbiol
Shrestha P, Bajracharya B, Shrestha D, Karna AK, Shah P, Gurung K, Ghimire S, Shrestha A.   +7 more
europepmc   +1 more source

Editorial: Horizontal transfer of antibiotic resistance genes in the environment: dynamic, contributing factors, and control. [PDF]

Front Microbiol
Ijaz UZ, Qiu Y, Zhou X, Yin H, Li B.
europepmc   +1 more source

Genetic diversity and occurrence of antibiotic resistance genes from community wastewater in Dhaka and Cox's Bazar, Bangladesh. [PDF]

One Health
Saha A, Hasan R, Ami JQ, Hasan MM, Amin N, Haque R, Rahman M, Jahan F, Hasan R, Liu P, Moe CL, Hossain ME, Rahman MZ.   +12 more
europepmc   +1 more source