Results 181 to 190 of about 3,260,507 (313)

Artificial Intelligence‐Empowered Single‐Cell Phenotyping for Rapid, Automated Pathogen Diagnostics

Advanced Science, EarlyView.
This work presents an integrated diagnostic platform that combines microfluidic single‐cell bacterial detection with artificial intelligence‐driven analysis for rapid antimicrobial susceptibility testing. Single‐cell phenotyping enables assessment of antibiotic response in only a few cell replication cycles, while AI analysis supports precise bacterial
Sabita Khadka, Bushra Raahat, Spyros Tragoudas, Hui Li   +3 more
wiley   +1 more source

Clinical efficacy of empiric antibiotic therapy in Chinese patients with cirrhosis and bacterial infections: A multicenter study. [PDF]

PLoS One
Sheng L, Zhang X, Weng H, Deng Q, Deng M, Wu X, Huang Z, Liu S, Wu R, Ma C, Xu Y, Zhong J, Yang J, Wu Y, Shen H, Ding F, Wang F, Zhai X, Peng C, Ren H, Jin J, Xu X, Li X, Ye X, Qian G, Sun S, Yao X, Miao H, Xiao Q, Ye S, Zhang Q, Xu X, Xu X, Yu Y, Tu H, Zhang X, Huang R, Yang Q, Sheng J, Shi Y, Yu X.   +40 more
europepmc   +1 more source

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

Nuclear medicine imaging to guide antibiotic therapy: an expert review. [PDF]

Br J Radiol
Albano D, Lauri C, Signore A, Treglia G.
europepmc   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Specialty-Related Differences in Adherence to Antibiotic Therapy Guidelines for Infective Endocarditis in Older Patients. [PDF]

Antibiotics (Basel)
Godaert L, Roubaud-Baudron C, Forestier E, Dramé M, The Endola Study Group.   +4 more
europepmc   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

The Role of Inflammatory Biomarkers and Microbiological Profile in Clinical Decision-Making for Antibiotic Therapy in Pediatric Patients: A Retrospective Study. [PDF]

Antibiotics (Basel)
Alidema FB, Hasani Alidema A, Lajçi Berisha N.   +2 more
europepmc   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Malignant External Otitis Complicated by Severe Allergic Reaction to Antibiotic Therapy. [PDF]

Cureus
Fejza J.
europepmc   +1 more source