Results 231 to 240 of about 634,748 (302)

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Sex differences in the blood metabolome of extremely preterm infants: a pilot study on the impact of antibiotic therapy. [PDF]

Biol Sex Differ
Costanzo M, Caterino M, Bianco S, Ruoppolo M, Sotgiu G, Puci M, Franconi F, Campesi I.   +7 more
europepmc   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Guiding Antibiotic Therapy with Machine Learning: Real-World Applications of a CDSS in Bacteremia Management. [PDF]

Life (Basel)
Gómez de la Torre JC, Frenkel A, Chavez-Lencinas C, Rendon A, Higuchi Y, Vela-Ruiz JM, Calpey J, Beaton R, Elijah I, Shachar I, Kim E, Valencia Osorio S, Lee JJ, Grogan G, Siegel J, Allman S, Hueda-Zavaleta M.   +16 more
europepmc   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Legends, dogmas, presumptions, and demystifications in antibiotic therapy. [PDF]

Rev Esp Quimioter
Blanes Hernández R, de Cossio Tejido S, Puchades Gimeno F, García-Bustos V, Salavert Lletí M.   +4 more
europepmc   +1 more source

Improving Access to Outpatient Antibiotic Therapy: Addition of Dalbavancin to a County Hospital Formulary for Complicated Staphylococcus aureus Infections. [PDF]

Cureus
Butt S, Tieman M, Kressel AB, Weaver B, Kays M.   +4 more
europepmc   +1 more source

Changing Bacterial Profiles and Antibiotic Susceptibility Patterns in Spontaneous Ascites Infection: A Shift in Empiric Combination Antibiotic Therapy? [PDF]

Antibiotics (Basel)
Kaplankıran C, Serin E.
europepmc   +1 more source