Results 91 to 100 of about 185,660 (297)

Expression patterns of core metabolic genes and elevated intracellular ROS confer drug tolerance in Staphylococcus aureus

Microbiology Spectrum
Staphylococcus aureus exhibits remarkable tolerance to antibiotic stress, facilitated by a complex network of cellular responses and metabolism controlled by numerous gene expression patterns that can be rapidly remodeled.
Jiahao Liu, Yeming Li, Haodong Liu, Shunhua Yan, Haoyi Jia, Yuxuan Yang, Wenting Hu, Jingjia Wang, Wenfeng Li, Huping Xue, Xin Zhao, Long Li, Pilong Liu   +12 more
doaj   +1 more source

Predicting Antibiotic-Associated Virulence of Pseudomonas aeruginosa Using an ex vivo Lung Biofilm Model

Frontiers in Microbiology, 2020
BackgroundBacterial biofilms are known to have high antibiotic tolerance which directly affects clearance of bacterial infections in people with cystic fibrosis (CF).
Marwa M. Hassan, Marwa M. Hassan, Niamh E. Harrington, Esther Sweeney, Freya Harrison   +4 more
doaj   +1 more source

Bacterial Biofilm and its Clinical Implications [PDF]

, 2018
Microbial biofilm created huge burden in treatment of both community and hospital infections. A biofilm is complex communities of bacteria attached to a surface or interface enclosed in an exopolysaccharide matrix and protected from unfavorable ...
Shakibaie, Prof
core  

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Bacterial defenses against a natural antibiotic promote collateral resilience to clinical antibiotics.

PLoS Biology, 2021
Bacterial opportunistic human pathogens frequently exhibit intrinsic antibiotic tolerance and resistance, resulting in infections that can be nearly impossible to eradicate.
Lucas A Meirelles, Elena K Perry, Megan Bergkessel, Dianne K Newman   +3 more
doaj   +1 more source

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]

, 2020
Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher, Dorrestein, Pieter C, Jarmusch, Alan K, Knight, Rob, Liyanage, Marlon, Ma, Joseph D, Momper, Jeremiah D, Tsunoda, Shirley M, Vrbanac, Alison   +8 more
core   +1 more source

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

Understanding tolerance to cell wall–active antibiotics

Annals of the New York Academy of Sciences, 2020
AbstractAntibiotic tolerance—the ability of bacteria to survive for an extended time in the presence of bactericidal antibiotics—is an understudied contributor to antibiotic treatment failure. Herein, I review the manifestations, mechanisms, and clinical relevance of tolerance to cell wall–active (CWA) antibiotics, one of the most important groups of ...
openaire   +2 more sources

Ti6Al4V‐Bioglass‐Copper Composites for Load‐Bearing Implants

Advanced Healthcare Materials, EarlyView.
We have designed and manufactured a novel Ti64‐based composite by adding 45S5 bioglass (BG) and copper (Cu). Adding BG on titanium improves wear resistance and biocompatibility, whereas Cu addition improves mechanical strength while providing inherent lifelong bacterial resistance.
Lochan Upadhayay, Bryson White, Susmita Bose, Amit Bandyopadhyay   +3 more
wiley   +1 more source

Biofabrication of Endothelialized, Intrinsically Vascularized 3D‐Printed Recombinant Spider Silk Scaffolds

Advanced Healthcare Materials, EarlyView.
This study evaluates 3D‐printed recombinant spider silk hydrogel eADF4(C16)‐RGD in a rat AV loop model for tissue engineering. Constructs with T17b endothelial progenitor cells showed enhanced vascularization and biodegradation. Results highlight the importance of scaffold design and cellular integration in improving vascular density and overall ...
Claire M. Weinhold, Stefanie Heltmann‐Meyer, Xuen J. Ng, Thomas Scheibel, Tobias Fey, Harald Wajant, Carol Geppert, Andreas Arkudas, Dominik Steiner, Raymund E. Horch   +9 more
wiley   +1 more source