Results 91 to 100 of about 855,762 (278)
Advanced Science, EarlyView.This study uncovers the activation, heterogeneity, and regulatory roles of pancreatic stellate cells (PSCs) at single‐cell and spatial levels. It further identifies PLXDC1+ PSCs near aggressive LRRC15+ cancer‐associated myofibroblasts and SPP1+ macrophages, forming a desmoplastic and immunosuppressive tumor niche that promotes CD8+ T cell exhaustion ...
Yanhua Du +12 more
wiley +1 more source
Trends of adverse drug reactions related-hospitalizations in Spain (2001-2006)
BMC Health Services Research, 2010 Background Adverse drug reactions (ADR) are a substantial cause of hospital admissions. We conducted a nationwide study to estimate the burden of hospital admissions for ADRs in Spain during a six-year period (2001-2006) along with the associated total ...
de Miguel Gil +4 more
doaj +1 more source
Social learning of prescribing behavior can promote population optimum of antibiotic use [PDF]
arXiv, 2018 The rise and spread of antibiotic resistance causes worsening medical cost and mortality especially for life-threatening bacteria infections, thereby posing a major threat to global health. Prescribing behavior of physicians is one of the important factors impacting the underlying dynamics of resistance evolution.
arxiv
Antibiotic treatment, duration of infectiousness, and disease transmission [PDF]
arXiv, 2020 Humans, domestic animals, orchard crops, and ornamental plants are commonly treated with antibiotics in response to bacterial infection. By curing infectious individuals, antibiotic therapy might limit the spread of contagious disease among hosts. But an antibiotic`s suppression of within-host pathogen density might also reduce the probability that the
arxiv
Advanced Science, EarlyView.An acoustic‐responsive therapeutic platform for synergistic sonopiezoelectric‐gaseous osteosarcoma therapy and bone regeneration is fabricated through the joint loading of few‐layer black phosphorus nanosheets and S‐Nitroso‐L‐glutathione onto the 3D‐printed bioactive glass scaffolds.
Haoyu Fang +8 more
wiley +1 more source
Біологічні студії, 2012 Application of special systems for drug delivery into target cells might be useful for overcoming several problems in treatment of dangerous diseases. These are: consequences of nonspecific negative effects of drugs towards healthy cells, low sensitivity
Yu. V. Senkiv +8 more
doaj +1 more source
Advanced Science, EarlyView.This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong +5 more
wiley +1 more source
Non-autonomous Cellular Responses to Ototoxic Drug-Induced Stress and Death
Frontiers in Cellular Neuroscience, 2017 The first major recognition of drug-induced hearing loss can be traced back more than seven decades to the development of streptomycin as an antimicrobial agent.
Shimon P. Francis, Lisa L. Cunningham
doaj +1 more source
Advanced Science, EarlyView.The RBR E3 ubiquitin ligase ARIH1, which is upregulated in colorectal cancer cells, promotes cell growth and metastasis and correlates with an unfavorable CRC prognosis. Mechanistically, ARIH1 catalyzes K63‐linked ubiquitination of PHB1, enhancing the interaction between PHB1 and Akt.
Ying Tong +13 more
wiley +1 more source
Antimicrobial resistance and use, and rates of hospitalization associated with bacterial infections, including sepsis [PDF]
arXiv, 2018 While the mechanisms and quantitative details are complex, few analysts would doubt that antibiotic use increases the prevalence of drug-resistant bacterial pathogens among all bacteria causing disease in a population. The causal connection between antibiotic use and the total incidence of severe bacterial infections, possibly mediated by antibiotic ...
arxiv