Results 131 to 140 of about 1,819,870 (340)

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

open access: yesAdvanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

Concentration-Dependent Enrichment of Linezolid-Resistant Staphylococcus aureus in an in vitro Dynamic Model

open access: yesАнтибиотики и Химиотерапия, 2020
To establish the relationships between the enrichment of resistant Staphylococcus aureus mutants and the ratio of daily area under the concentration - time curve (AUC24) to the MIC of linezolid, a mixed inoculum of linezolid-susceptible and -resistant ...
K. N. Alieva   +4 more
doaj  

Engineering the Hierarchical Porosity of Granular Hydrogel Scaffolds Using Porous Microgels to Improve Cell Recruitment and Tissue Integration

open access: yesAdvanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
By fabricating and covalently assembling gelatin methacryloyl (GelMA) porous microgels, a new class of granular hydrogel scaffolds with hierarchical porosity is developed. These scaffolds have a significantly higher void fraction than their counterparts made up of nonporous microgels, enhancing cell recruitment and tissue integration. This research may
Alexander Kedzierski   +9 more
wiley   +1 more source

Post Penicillin Antibiotics: From acceptance to resistance? [PDF]

open access: yes, 2000
Edited transcript of a Witness Seminar held at the Wellcome Institute for the History of Medicine, in London, on 12 May 1998. First published by the Wellcome Trust, 2000. ©The Trustee of the Wellcome Trust, London, 2000.
Reynolds, LA, Tansey, EM
core  

Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells

open access: yesAdvanced Functional Materials, EarlyView.
CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham   +9 more
wiley   +1 more source

Synthesis and Biological Activity of New Antimicrobial Agents - Hybrid Derivatives of Maleimides and Triindolylmethanes

open access: yesАнтибиотики и Химиотерапия, 2020
Methods for the synthesis of hybrid molecules that combine the structure of a highly active antimicrobial compounds - tris(1-alkylindol-3-yl)methylium as well as 3-(indol-1-yl)maleimides that previously showed activity against some protein kinases have ...
S. N. Lavrenov   +11 more
doaj  

Self‐supportive Three‐Way Photoelectrochemical System Achieving Uranium Recycling, Organic Oxidation, and Electricity Generation in Complex Waters

open access: yesAdvanced Functional Materials, EarlyView.
A self‐sustaining solar photoelectrochemical cell (SS‐PEC) is developed to recover uranium from aqueous UO22+ with concurrent organic oxidation and electricity production. The monolithical photoanode directly captures electrons from organic compounds, leading to the oxidation of organic compounds and the decomposition of uranium‐organic complexes ...
Yumei Wang   +7 more
wiley   +1 more source

The Genesis of Methicillin-Resistant \u3ci\u3eStaphylococcus aureus\u3c/i\u3e: A Modern Day Leprosy and Hospital Menace [PDF]

open access: yes, 2009
Methicillin-Resistant Staphylococcus aureus leads to more deaths than AIDS and resists most antibiotics.
Gillen, Alan L.
core   +1 more source

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

open access: yesAdvanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson   +12 more
wiley   +1 more source

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