Results 51 to 60 of about 2,694,182 (391)

Antimicrobial activity of ceftobiprole and comparator agents when tested against gram-positive and -negative organisms collected across China (2016–2018)

BMC Microbiology, 2022
Background Ceftobiprole is a fifth-generation cephalosporin which has been reported to have broad antibacterial spectrum when tested against bacteria collected from other countries except China.
Yin Dandan, Wu Shi, Yang Yang, Zheng Yonggui, Demei Zhu, Guo Yan, Fupin Hu   +6 more
doaj   +1 more source

Approach to Searching for the Producers of Antibiotics That Overcome Drug Resistance of Microorganisms

Антибиотики и Химиотерапия, 2021
Currently, the problem of antibiotic resistance of opportunistic and pathogenic microorganisms is extremely urgent. In order to find new effective natural antibiotics, it is necessary to intensify the search process.
M. V. Demiankova, V. S. Sadykova, A. A. Glukhova, T. A. Efimenko, Yu. V. Boykova, N. D. Malkina, V. G. Kormilitsina, S. O. Sharapchenko, I. G. Sumarukova, B. F. Vasilieva, T. D. Ivankova, L. P. Terekhova, N. I. Gabrielyan, O. V. Efremenkova   +13 more
doaj   +1 more source

Meta‐analysis of oral antibiotics, in combination with preoperative intravenous antibiotics and mechanical bowel preparation the day before surgery, compared with intravenous antibiotics and mechanical bowel preparation alone to reduce surgical‐site infections in elective colorectal surgery [PDF]

, 2018
Background: Surgical‐site infection (SSI) is a potentially serious complication following colorectal surgery. The present systematic review and meta‐analysis aimed to investigate the effect of preoperative oral antibiotics and mechanical bowel ...
McMahon, A.J., McSorley, S.T., Steele, C.W.   +2 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Empiric Antibiotic Therapy in the Treatment of Community-acquired Pneumonia in a General Hospital in Saudi Arabia [PDF]

, 2019
Background: Guideline-based empiric antimicrobial therapy is recommended for the treatment of community-acquired pneumonia (CAP). In this study, we evaluate the pattern of empiric antibiotics of CAP patients.
Al-Tawfiq, Jaffar A., Hinedi, Kareem, Momattin, Hisham   +2 more
core   +1 more source

Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity—A Pharmaco-Toxicological Screening

Antibiotics, 2021
Antibiotics are considered as a cornerstone of modern medicine and their discovery offers the resolution to the infectious diseases problem. However, the excessive use of antibiotics worldwide has generated a critical public health issue and the ...
Daniel Florin Pancu, A. Scurtu, I. Macașoi, D. Marti, Marius Mioc, Codruța Șoica, D. Coricovac, D. Horhat, M. Poenaru, C. Dehelean   +9 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Perioperative Antibiotics [PDF]

The Journal of Arthroplasty, 2014
infection, arthroplasty ...
Hansen, Erik, Belden, Katherine, Silibovsky, Randi, Vogt, Markus, Arnold, William, Bicanic, Goran, BINI, STEFANO, CATANI, Fabio, Chen, Jiying, Ghazavi, Mohammad, Godefroy, Karine M., Holham, Paul, Hosseinzadeh, Hamid, Kim II, Kang, Kirketerp Moøller, Klaus, Lidgren, Lars, Lin, Jian Hao, Lonner, Jess H., Moore, Christopher C., Papagelopoulos, Panayiotis, Poultsides, Lazaros, Randall, R. Lor, Roslund, Brian, Saleh, Khalid, Salmon, Julia V., Schwarz, Edward, Stuyck, Jose, Dahl, Annette W, Yamada, Koji   +28 more
openaire   +7 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Is 24 hour observation in hospital after stopping intravenous antibiotics in neonates justified? [PDF]

, 2009
Background: Antibiotics are given empirically for suspected sepsis in up to 75% of neonates on the Neonatal and Paediatric Intensive Care Unit (NPICU), after completion of a septic screen. Treatment is discontinued on day 3 if cultures remain negative or
Andrejevic, Hermoine, Attard Montalto, Simon, Fenech, Josella, Said Conti, Valerie   +3 more
core