Results 61 to 70 of about 1,881,968 (357)
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
NON-ANTIBIOTIC USE OF ANTIBIOTICS [PDF]
Postępy Mikrobiologii - Advancements of Microbiology, 2018 Abstract Antibiotics are widely used medicines in the treatment of infectious diseases. However, some of them show also non-antibiotic properties, which are increasingly used in the treatment of non-infectious diseases. The authors of this publication believe that this is one of the reasons behind antibiotic dissemination in the ...
Dorota Ksiądzyna +2 more
openaire +3 more sources
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Antibiotics and Environment [PDF]
Antibiotics, 2020 Since the discovery of penicillin by Alexander Fleming in 1928, the use of antibiotics has become the golden standard in the treatment of bacterial infections of all kinds [...]
openaire +4 more sources
COMPOUNDS BASED ON TRIS(1-ALKYLINDOL-3-YL)METHAN FOR OVERCOMING DRUG RESISTANCE IN PATHOGENS
Антибиотики и Химиотерапия, 2020 Trls(1-alkylindol-3-yl)methylium salts that are trls(1-alkylindol-3-yl)methan derivatives with high antibacterial and antifungal activity were obtained through chemical synthesis.
A. S. Trenin +7 more
doaj
mSphere, 2022 Ceftazidime-avibactam is an effective antibiotic combination of a β-lactam and a β-lactamase inhibitor against Klebsiella pneumoniae-carbapenemase (KPC)-producing Enterobacterales.
Siquan Shen +7 more
doaj +1 more source
Antibiotics, 2020 The unprecedented use of antibiotics that led to development of resistance affect human health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases progressed with the acquisition and as such development of antibiotic
Hana Al AlSheikh +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Антибиотики и Химиотерапия, 2020 Novel compounds among 3,4-disubstituted maleimlde derivatives that reveal a pronounced antimicrobial activity in vitro against Gram-positive bacteria, yeast Candida albicans, and fungi Aspergillus niger were obtained through total chemical synthesis. All
S. A. Lakatosh +5 more
doaj
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source