Empiric Antibiotic Therapy in the Treatment of Community-acquired Pneumonia in a General Hospital in Saudi Arabia [PDF]
, 2019 Background: Guideline-based empiric antimicrobial therapy is recommended for the treatment of community-acquired pneumonia (CAP). In this study, we evaluate the pattern of empiric antibiotics of CAP patients.
Al-Tawfiq, Jaffar A. +2 more
core +1 more source
The impact of antibiotic use on transmission of resistant bacteria in hospitals: Insights from an agent-based model [PDF]
, 2018 Extensive antibiotic use over the years has led to the emergence and spread of antibiotic resistant bacteria (ARB). Antibiotic resistance poses a major threat to public health since for many infections antibiotic treatment is no longer effective ...
DRIVE-AB consortium +5 more
core +2 more sources
Антибиотики и Химиотерапия, 2021 Currently, the problem of antibiotic resistance of opportunistic and pathogenic microorganisms is extremely urgent. In order to find new effective natural antibiotics, it is necessary to intensify the search process.
M. V. Demiankova +13 more
doaj +1 more source
Meta‐analysis of oral antibiotics, in combination with preoperative intravenous antibiotics and mechanical bowel preparation the day before surgery, compared with intravenous antibiotics and mechanical bowel preparation alone to reduce surgical‐site infections in elective colorectal surgery [PDF]
, 2018 Background: Surgical‐site infection (SSI) is a potentially serious complication following colorectal surgery. The present systematic review and meta‐analysis aimed to investigate the effect of preoperative oral antibiotics and mechanical bowel ...
McMahon, A.J. +2 more
core +1 more source
‘There is no choice apart from antibiotics…’: qualitative analysis of views on urinary infections in pregnancy and antimicrobial resistance [PDF]
, 2020 Background: Antimicrobial resistance (AMR) is a health risk as it can lead to life-threatening infections. There has been a rise in resistant urinary tract infections (UTIs) which is the most common infection in pregnancy.
Bandura A +8 more
core +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
European intensive care physicians’ experience of infections due to antibiotic-resistant bacteria [PDF]
, 2020 Background Antimicrobial resistance (AMR) compromises the treatment of patients with serious infections in intensive care units (ICUs), and intensive care physicians are increasingly facing patients with bacterial infections with limited or no adequate ...
De Waele, Jan +9 more
core +2 more sources
Oral versus Intravenous Antibiotics for Bone and Joint Infection
New England Journal of Medicine, 2019 BACKGROUND The management of complex orthopedic infections usually includes a prolonged course of intravenous antibiotic agents. We investigated whether oral antibiotic therapy is noninferior to intravenous antibiotic therapy for this indication. METHODS
Ho‐Kwong Li +58 more
semanticscholar +1 more source
Are antibiotics naturally antibiotics?
Journal of Industrial Microbiology & Biotechnology, 2006 Antibiotics have been used for more than 50 years and are the cornerstone of infectious disease treatment; in addition, these low-molecular-weight bioactive compounds have been applied to many other therapeutic purposes. However, there is almost no information on the evolutionary biology or ecology of naturally occurring low-molecular-weight compounds.
openaire +3 more sources
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source