Results 11 to 20 of about 598,963 (290)

Removal of natural anti-αGal antibodies elicits protective immunity against Gram-negative bacterial infections

Frontiers in Immunology, 2023
Antibody-dependent enhancement (ADE) of bacterial infections occurs when blocking or inhibitory antibodies facilitate the infectivity of pathogens. In humans, antibodies involved in ADE of bacterial infections may include those naturally produced against
Sara Olivera-Ardid, Daniel Bello-Gil, Magdiel Perez-Cruz, Cristina Costa, Mariana Camoez, Mariana Camoez, M. Angeles Dominguez, M. Angeles Dominguez, Yara Ferrero-Alves, Jose Miguel Vaquero, Nailya Khasbiullina, Nadezhda V. Shilova, Nicolai V. Bovin, Rafael Mañez, Rafael Mañez   +14 more
doaj   +1 more source

Increased levels of IgG antibodies against human HSP60 in patients with spondyloarthritis. [PDF]

PLoS ONE, 2013
Spondyloarthritis (SpA) comprises a heterogeneous group of inflammatory diseases, with strong association to human leukocyte antigen (HLA)-B27. A triggering bacterial infection has been considered as the cause of SpA, and bacterial heat shock protein ...
Astrid Hjelholt, Thomas Carlsen, Bent Deleuran, Anne Grethe Jurik, Berit Schiøttz-Christensen, Gunna Christiansen, Svend Birkelund   +6 more
doaj   +1 more source

Monoclonal antibodies and bacterial virulence [PDF]

Virulence, 2017
This issue of Virulence features an article entitled “Antibodies to Staphylococcus aureus capsular polysaccharides 5 and 8 perform similarly in vitro but are functionally distinct in vivo”1 which d...
Luigi Iannetti, Mirella Luciani
openaire   +3 more sources

Inhibition of Bacterial Superantigens by Peptides and Antibodies [PDF]

Infection and Immunity, 2001
ABSTRACTThe pyrogenic exotoxins of group A streptococci and staphylococcal enterotoxins are a family of structurally related superantigens with similar biological activity. Two distinct areas have been identified which have a highly conserved amino acid homology in all of the toxin families.
Pavel Pugach, Jason D. Bannan, Khosrow Kashfi, Khosrow Kashfi, Alain Charles, John B. Zabriskie, Kumar Visvanathan   +6 more
openaire   +4 more sources

Functional Activity of Antibodies Directed towards Flagellin Proteins of Non-Typhoidal Salmonella. [PDF]

PLoS ONE, 2016
Non-typhoidal Salmonella (NTS) serovars Typhimurium and Enteritidis are major causes of invasive bacterial infections in children under 5 years old in sub-Saharan Africa, with case fatality rates of ~20%.
Girish Ramachandran, Sharon M Tennant, Mary A Boyd, Jin Y Wang, Mohan E Tulapurkar, Marcela F Pasetti, Myron M Levine, Raphael Simon   +7 more
doaj   +1 more source

Compensatory intestinal immunoglobulin response after vancomycin treatment in humans

Gut Microbes, 2021
Intestinal immunoglobulins (Ig) are abundantly secreted antibodies that bind bacteria and bacterial components in the gut. This binding is considered to accelerate bacterial transit time and prevent the interaction of potentially immunogenic compounds ...
Torsten P. M. Scheithauer, Guido J. Bakker, Maaike Winkelmeijer, Mark Davids, Max Nieuwdorp, Daniël H. van Raalte, Hilde Herrema   +6 more
doaj   +1 more source

Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease

npj Vaccines, 2021
Highly pathogenic emm1 Streptococcus pyogenes strains secrete the multidomain Streptococcal inhibitor of complement (SIC) that binds and inactivates components of the innate immune response. We aimed to determine if naturally occurring or vaccine-induced
Lionel K. K. Tan, Mark Reglinski, Daryl Teo, Nada Reza, Lucy E. M. Lamb, Vaitehi Nageshwaran, Claire E. Turner, Mats Wikstrom, Inga-Maria Frick, Lars Bjorck, Shiranee Sriskandan   +10 more
doaj   +1 more source

Investigation of Cas9 antibodies in the human eye

Nature Communications, 2022
Pre-existing antibodies against Cas9 proteins represent a potential issue for gene therapies, including those targeting the eye. Here the authors assess the presence of intraocular antibodies, and show that Cas9 antibodies were prevalent in human serum ...
Marcus A. Toral, Carsten T. Charlesworth, Benjamin Ng, Teja Chemudupati, Shota Homma, Hiromitsu Nakauchi, Alexander G. Bassuk, Matthew H. Porteus, Vinit B. Mahajan   +8 more
doaj   +1 more source

A Novel Autoantibody Induced by Bacterial Biofilm Conserved Components Aggravates Lupus Nephritis

Frontiers in Immunology, 2021
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multiple autoantibody production and often affects the kidneys, known as lupus nephritis. However, the mechanism underlying lupus nephritis development is unclear.
Wenyan Fu, Wenyan Fu, Yu Liu, Yu Liu, Fangjie Liu, Fangjie Liu, Chenghua Liu, Chenghua Liu, Jingjing Li, Jiali Niu, Peng Han, Dan Xu, Jiaojiao Hou, Yuanfang Ma, Jiannan Feng, Jiannan Feng, Zhanguo Li, Rong Mu, Guang Yang, Guang Yang   +19 more
doaj   +1 more source

Specificity of secretory antibodies to bacterial immunogens [PDF]

Infection and Immunity, 1976
The present investigation examined the specificity of the salivary immune response of axenic and conventional mice to topically administered Salmonella typhi, S. gallinarum, and S. typhimurium. Specific antibacterial antibodies were determined by passive hemagglutination and bacterial agglutination. Reciprocal antibody titers up to 320 were detected in
J A Molinari, J L Ebersole
openaire   +2 more sources