Results 31 to 40 of about 621,927 (266)

Revealing microbial recognition by specific antibodies [PDF]

, 2015
Background: Recognition of microorganisms by antibodies is a vital component of the human immune response. However, there is currently very limited understanding of immune recognition of 50 % of the human microbiome which is made up of as yet un ...
Collado, M. Carmen, Culshaw, Shauna, Džunková, Mária, D’Auria, Giuseppe, Mira, Alex, Simón-Soro, Áurea   +5 more
core   +1 more source

Predicted serotype-specific effectiveness of pneumococcal conjugate vaccines V114 and PCV20 against invasive pneumococcal disease in children

Expert Review of Vaccines
Background Next-generation, higher-valency pneumococcal conjugate vaccines (PCVs), 15-valent PCV V114 and 20-valent PCV (PCV20), have been assessed by comparing their immune responses across serotypes shared with the 13-valent PCV (PCV13).
Josiah Ryman, Jeffrey R. Sachs, Ka Lai Yee, Natalie Banniettis, Jessica Weaver, Thomas Weiss   +5 more
doaj   +1 more source

Utility of serological markers in inflammatory bowel diseases: Gadget or magic? [PDF]

, 2007
The panel of serologic markers for inflammatory bowel diseases (IBD) is rapidly expanding. Although anti-Saccharomyces cerevisiae antibodies (ASCA) and atypical perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) remain the most widely ...
Altorjay, István, Lakatos, Péter László, Norman, G. L., Papp, Mária   +3 more
core   +1 more source

The Immunogenicity of Glutaraldehyde Inactivated PTx Is Determined by the Quantity of Neutralizing Epitopes

Vaccines
Background/Objectives: Chemically or genetically detoxified pertussis toxin (PTx) is a crucial antigen component of the acellular pertussis vaccine. Chemical detoxification using glutaraldehyde generally causes significant structural changes to the toxin.
Xi Wang, Xinyue Cui, Chongyang Wu, Ke Tao, Shuyuan Pan, Wenming Wei   +5 more
doaj   +1 more source

Artificial surface labelling of Escherichia coli with StrepTagII antigen to study how monoclonal antibodies drive complement-mediated killing

Scientific Reports, 2023
Antibodies play a key role in the immune defence against Gram-negative bacteria. After binding to bacterial surface antigens, IgG and IgM can activate the complement system and trigger formation of lytic membrane attack complex (MAC) pores.
Remy M. Muts, Maurits A. den Boer, Bart W. Bardoel, Piet C. Aerts, Carla J. C. de Haas, Albert J. R. Heck, Suzan H. M. Rooijakkers, Dani A. C. Heesterbeek   +7 more
doaj   +1 more source

Diverse Mechanisms of Protective Anti-Pneumococcal Antibodies

Frontiers in Cellular and Infection Microbiology, 2022
The gram-positive bacterium Streptococcus pneumoniae is a leading cause of pneumonia, otitis media, septicemia, and meningitis in children and adults. Current prevention and treatment efforts are primarily pneumococcal conjugate vaccines that target the ...
Aaron D. Gingerich, Jarrod J. Mousa, Jarrod J. Mousa, Jarrod J. Mousa   +3 more
doaj   +1 more source

Reducing Campylobacter jejuni colonization in broiler chickens by in-feed supplementation with hyperimmune egg yolk antibodies [PDF]

, 2019
Campylobacter infections sourced mainly to poultry products, are the most important bacterial foodborne zoonoses worldwide. No effective measures to control these infections in broiler production exist to date.
Canessa, Stefano, De Zutter, Lieven, Garmyn, An, Haesebrouck, Freddy, Heyndrickx, Marc, Martel, An, Pasmans, Frank, Van Rysselberghe, Nathalie, Vandeputte, Jasmien   +8 more
core   +1 more source

Disease-Enhancing Antibodies Improve the Efficacy of Bacterial Toxin-Neutralizing Antibodies [PDF]

Cell Host & Microbe, 2013
During infection, humoral immunity produces a polyclonal response with various immunoglobulins recognizing different epitopes within the microbe or toxin. Despite this diverse response, the biological activity of an antibody (Ab) is usually assessed by the action of a monoclonal population.
Chow, Siu-Kei, Smith, Cameron, MacCarthy, Thomas, Pohl, Mary Ann, Bergman, Aviv, Casadevall, Arturo   +5 more
openaire   +2 more sources

Bioaffinity detection of pathogens on surfaces [PDF]

, 2010
The demand for improved technologies capable of rapidly detecting pathogens with high sensitivity and selectivity in complex environments continues to be a significant challenge that helps drive the development of new analytical techniques. Surface-based
Faisal, S. N., Kim, S., Lee, H. J., Lee, J., Wark, Alastair   +4 more
core   +1 more source

Human antibody targeting Vibrio cholerae O1 O-specific polysaccharide induces an amotile hypovirulent bacterial phenotype: mechanism of protection against cholera

mBio
Antibodies targeting the O-specific polysaccharide (OSP) of Vibrio cholerae O1 are crucial determinants of protection against cholera. These antibodies agglutinate bacteria and, even in sub-agglutinating conditions, inhibit V. cholerae motility.
Smriti Verma, Murat Cetinbas, Meagan Kelly, Stefania Senger, Christina S. Faherty, Jeshina Janardhanan, Chanchal R. Wagh, Taufiqur Rahman Bhuiyan, Fahima Chowdhury, Ashraful Islam Khan, Aklima Akter, Richelle C. Charles, Jason B. Harris, Stephen B. Calderwood, Jens Wrammert, Matthew K. Waldor, Merrill Asp, Jung-Shen Benny Tai, Jing Yan, Peng Xu, Pavol Kováč, Ruslan I. Sadreyev, Firdausi Qadri, Edward T. Ryan   +23 more
doaj   +1 more source