Journal of the European Academy of Dermatology and Venereology, EarlyView.A matching‐adjusted indirect treatment comparison (MAIC) was conducted, comparing approved biologics for long‐term (48–52 weeks) treatment of moderate‐to‐severe hidradenitis suppurativa (HS). Using weighted patient‐level trial data allowed re‐estimation of relative bimekizumab efficacy compared with aggregate secukinumab and adalimumab trial data ...
Thrasyvoulos Tzellos +9 more
wiley +1 more source
Rituximab-Induced Serum Sickness in Patients With Multiple Sclerosis: A Case Report and Literature Review. [PDF]
CureusSikkal A +4 more
europepmc +1 more source
Litifilimab efficacy on skin outcomes in cutaneous lupus erythematosus in the Phase 2 LILAC study
Journal of the European Academy of Dermatology and Venereology, EarlyView.Our findings show that greater proportions of litifilimab‐treated participants than placebo experienced 20%, 50%, 70% or 90% improvements in CLASI‐A score from baseline and CLASI‐A scores of 0–1 or 0–3. Similar results were observed using physician global assessments, supporting the Phase 2 LILAC study primary analysis in CLE.
Victoria P. Werth +8 more
wiley +1 more source
Bimekizumab efficacy using IHS4 outcomes in hidradenitis suppurativa: Results from BE HEARD I and II
Journal of the European Academy of Dermatology and Venereology, EarlyView.The majority of bimekizumab‐treated patients shifted from severe to mild and moderate IHS4 stages, and nearly 25% achieved an IHS4 of 0 by Week 48. Bimekizumab led to clinically meaningful improvements across IHS4 outcome measures. These data highlight an opportunity to address the need for effective treatments against draining tunnels.
Thrasyvoulos Tzellos +15 more
wiley +1 more source
Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human V<sub>H</sub>1-2-rearranging mouse models. [PDF]
Proc Natl Acad Sci U S ABatra H +27 more
europepmc +1 more source
CD4+ T Cells Predict Relapse in Pemphigus Vulgaris Treated With Rituximab: A Retrospective Study
Oral Diseases, EarlyView.ABSTRACT Objective This study evaluated the CD4+ T‐cell role in mediating post‐Rituximab Pemphigus vulgaris (PV) relapse, comparing CD4+ count and CD4+/CD20+ ratio between patients who achieved remission and those who relapsed. Methods The clinical course of 27 PV patients treated with Rituximab was evaluated after a 32‐month median follow‐up. CD4+ and
Simone Liguori +9 more
wiley +1 more source
Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases
Periodontology 2000, EarlyView.Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva +2 more
wiley +1 more source
QX008N, an Anti-TSLP Monoclonal Antibody: Pharmacokinetics, Tolerability, and Immunogenicity in Healthy Chinese Subjects. [PDF]
Clin Transl SciShen ZW +7 more
europepmc +1 more source
Emerging therapeutics for the treatment of light chain and transthyretin amyloidosis [PDF]
, 2019 Lenihan, Daniel J +2 more
core +1 more source
International Journal of Cancer, Volume 159, Issue 1, Page 11-29, 1 July 2026.Abstract Gastric signet ring cell carcinoma (GSRCC) is a special type of gastric cancer common in young women. Diffuse gastric cancer (DGC) begins with intramucosal lesions comprising differentiated GSRCC cells. Genetically, GSRCC and DGC are clonally identical, with their morphology influenced by extracellular Wnt signaling.
Qian Wang +5 more
wiley +1 more source