Results 201 to 210 of about 64,954 (254)
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Monoclonal Antibody to Human Cytotrophoblast
American Journal of Reproductive Immunology, 1984ABSTRACT: A monoclonal antibody (18B/A5) has been generated against human first trimester trophoblast membranes which, unlike others so far reported in the literature, reacted only with cytotrophoblast and not with syncytiotrophoblast. Although the identity of the target antigen has not yet been established, the antibody could be a valuable tool for ...
Y W, Loke, S, Day
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Monoclonal Antibodies to Human Choriocarcinoma
American Journal of Reproductive Immunology and Microbiology, 1986ABSTRACT: We have established two monoclonal antibodies (TM7‐3 and TM3‐8) that react to choriocarcinoma cells. Both of these monoclonal antibodies have shown a similar reactive pattern to human cell lines, normal and neoplastic trophoblast tissues, and other fetal and adult tissues.
K, Yamashita +3 more
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Monoclonal antibodies to human erythrocytes
European Journal of Immunology, 1982AbstractEight monoclonal antibodies from mouse hybridomas raised to normal human erythrocytes were tested with a panel of null‐type erythrocytes, enzyme‐treated normal cells, and by inhibition with human erythrocyte sialoglycoproteins. Two antibodies reacted poorly or not at all with RhNULL cells.
D J, Anstee, P A, Edwards
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Monoclonal Antibody to Human Thyrotropin*
The Journal of Clinical Endocrinology & Metabolism, 1982Using the technique of somatic cell fusion, a monoclonal antibody to human TSH (hTSH) has been produced. The monoclonal antibody (anti-hTSH 1/1) has an affinity (Kd = 4.04 x 10(-9) M/liter) for hTSH which is slightly less than that of the polyclonal antisera (Kd = 9.8 x 10(-10) M/liter) derived from the same mouse used for the fusion experiment.
Ridgway, E C +3 more
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Monoclonal Antibodies to Human Nephrin
Hybridoma and Hybridomics, 2004Nephrin is a 180-200-kDa transmembrane protein of the immunoglobulin superfamily. In the kidney, nephrin localizes to the slit diaphragm (SD) between interdigitating podocyte foot processes and mutations in the nephrin gene cause congenital nephrotic syndrome.
Vesa, Ruotsalainen +4 more
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Generating human monoclonal antibodies
Medical Oncology and Tumor Pharmacotherapy, 1984Present methods and systems for the generation of human monoclonal antibodies are briefly reviewed. The specificities of the available reagents are outlined. It would appear that the generation using hybridoma methods of human monoclonal antibodies to human tumor cell surface antigens is a rare event and that methods of in vitro immunostimulation may ...
A M, Neville, P A, Edwards, M J, O'Hare
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Immunology Today, 1988
Abstract Reproducible and efficient production of human monoclonal antibodies of predefined specificity has proved to be a notoriously difficult task. Many variations on basic production techniques now exist and, as Keith Thompson reviews here, the comparative ease with which they can now be made promises to open up numerous new research avenues.
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Abstract Reproducible and efficient production of human monoclonal antibodies of predefined specificity has proved to be a notoriously difficult task. Many variations on basic production techniques now exist and, as Keith Thompson reviews here, the comparative ease with which they can now be made promises to open up numerous new research avenues.
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Human Monoclonal Antibodies to Human Cytomegalovirus
The Journal of Infectious Diseases, 1989Human monoclonal antibodies (HMAbs) to human cytomegalovirus (HCMV) have been developed by using electric field-induced cell fusion of human B lymphocytes to the human-mouse cell line SBC-H20. By this procedure, multiple hybridomas have been produced that secrete IgG 1 HMAbs with distinct patterns of indirect immunofluorescence on HCMV-infected cells ...
S K, Foung +6 more
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Humanization and Simultaneous Optimization of Monoclonal Antibody
2013Antibody humanization is an essential technology for reducing the potential risk of immunogenicity associated with animal-derived antibodies and has been applied to a majority of the therapeutic antibodies on the market. For developing an antibody molecule as a pharmaceutical at the current biotechnology level, however, other properties also have to be
T, Kuramochi +3 more
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Human Monoclonal Antibodies: The Benefits of Humanization
2018The major reasons for developing human monoclonal antibodies were to be able to efficiently manipulate their effector functions while avoiding immunogenicity seen with rodent antibodies. Those effector functions involve interactions with the complement system and naturally occurring Fc receptors on diverse blood white cells.
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