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Human Monoclonal Antibodies: The Benefits of Humanization
2018The major reasons for developing human monoclonal antibodies were to be able to efficiently manipulate their effector functions while avoiding immunogenicity seen with rodent antibodies. Those effector functions involve interactions with the complement system and naturally occurring Fc receptors on diverse blood white cells.
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Human Monoclonal Antibody Technology [PDF]
, 1994 The success of Kohler and Milstein (1975) in immortalizing specific antibody secreting cell lines of rodent origin inevitably led to similar attempts to generate human monoclonals. Initially this effort was largely driven by the belief that such products would be clinically (especially therapeutically) superior to their rodent counterparts. In addition
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Production of Human Monoclonal Antibodies
1984The need to obtain human monoclonal antibodies has not been overshadowed by the immense success of mouse monoclonal antibody technology. Human monoclonal antibodies will be less antigenic for human in vivo studies and therapy; they will be more likely to recognize antigenic subtleties not easily detected by xenogeneic antibodies, and they will have ...
Bradley J. Dyer +6 more
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Characterization of Monoclonal Antibodies to Human OC43
1987Human coronaviruses are important respiratory pathogens (1). These viruses have also been implicated in human neurological diseases (2, 3), and some reports have suggested an association with the demyelinating condition multiple sclerosis (4, 5, 6), although other studies cast doubt upon the role of coronaviruses in this disease (7, 8, 9, 10, 11).
Stephen A. Stohlman +4 more
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Fully Human Therapeutic Monoclonal Antibodies
Journal of Immunotherapy, 2006Monoclonal antibody (mAb) therapy has been facilitated by a number of technologic advances over the past 30 years. Whereas hybridoma development of murine mAbs was requisite for the development of mAbs as drugs, the inherent immunogenicity of rodent sequences in humans has presented obstacles to the clinical application of mAbs.
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Toward Human Monoclonal Antibodies
1990OKT3 is a murine monoclonal antibody directed against an epitope on one of the subunits of the CD3 complex on human T cells. CD3 is associated with the T cell receptor and seems to play a role in the expression of the receptor. Clinically it is used as rescue treatment in renal allograft rejection and is currently being tested for use prophylactically ...
Dennis R. Burton +3 more
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Monoclonal antibodies in human reproduction
1984This workshop centred on the effect which monoclonal antibodies (mAbs) are now beginning to make in various fields of research in human reproduction. An introduction by the chairperson, L. Mettler (Kiel, W. Germany), outlined the background to much of the technology involved in the production of mAbs based from the original work of Kohler and Milstein ...
P. M. Johnson, K. Hannon, L. Mettler
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MONOCLONAL ANTIBODIES TO HUMAN TRANSFERRINS
British Journal of Haematology, 1988Anne B. Mason +2 more
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Monoclonal antibody to human fibronectin
Cell Biology International Reports, 1980Walsh, F S, Dhut, S
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