Data from 2731 patients with hidradenitis suppurativa (HS) treated with biologics for 12–16 weeks in phase III randomized controlled trials (RCT) were included in a network meta‐analysis (NMA). Adalimumab showed the highest efficacy in achieving a clinical HS response 50 (HiSCR50) and the lowest incidence of adverse events (AE).
Laura Calabrese+4 more
wiley +1 more source
Clinical Scaleup of Humanized AnnA1 Antibody Yielded Unexpected High Reticuloendothelial (RES) Uptake in Mice. [PDF]
Xu LL+7 more
europepmc +1 more source
European Guideline (EuroGuiDerm) on atopic eczema: Living update
The updated guideline includes a new evidence‐based recommendation for the IL‐13 inhibitor lebrikizumab. In addition, the Janus kinase inhibitors baricitinib and abrocitinib, which were initially only approved for adult patients, are now also recommended for children from the age of 2 and adolescents from the age of 12, respectively.
A. Wollenberg+31 more
wiley +1 more source
Evaluating the immune effector functions induced by humanized anti-CD99 antibody in eliminating T lymphoblastic leukemia/lymphoma cells. [PDF]
Kotemul K+7 more
europepmc +1 more source
Prostate-Specific Membrane Antigen-Targeted Antibody-Drug Conjugates: A Promising Approach for Metastatic Castration-Resistant Prostate Cancer. [PDF]
Shih CH, Hsieh TY, Sung WW.
europepmc +1 more source
Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva+2 more
wiley +1 more source
Current Review of Monoclonal Antibody Therapeutics in Small Animal Medicine. [PDF]
Wang J+4 more
europepmc +1 more source
Updated insights into the molecular pathogenesis of canine atopic dermatitis
Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley +1 more source
Pyoderma gangrenosum in a patient with multiple sclerosis under natalizumab treatment: a case report. [PDF]
Kohandel K+4 more
europepmc +1 more source