Results 231 to 240 of about 405,156 (331)

CRISPR/Cas9‐Mediated Knockouts of the ALG3 and GNTI in N. benthamiana and Their Application to Pharmaceutical Production

Plant Biotechnology Journal, EarlyView.
ABSTRACT N‐Glycosylation critically influences the efficacy, safety and pharmacokinetic properties of biopharmaceuticals. Plant expression platforms offer multiple advantages for the production of N‐glycosylated proteins, but their use is impeded by the presence of plant‐specific N‐glycan epitopes, which raise concerns of possible immunogenicity to ...
Dolgormaa Bataa, Hiroyuki Kajiura, Reimi Lai Sang Sawada‐Choi, Yukino Yamashita, Takeshi Ishimizu, Ryo Misaki, Atsushi Takeda, Kazuhito Fujiyama   +7 more
wiley   +1 more source

Characterization of the biological anti-staphylococcal functionality of hUK-66 IgG1, a humanized monoclonal antibody as substantial component for an immunotherapeutic approach

Human Vaccines & Immunotherapeutics, 2014
B. Oesterreich, Birgit Lorenz, Tim Schmitter, R. Kontermann, Michael Zenn, B. Zimmermann, M. Haake, U. Lorenz, K. Ohlsen   +8 more
semanticscholar   +1 more source

Synthesis and characterization of a functional benzoylecgonine - bovine serum albumin conjugate for quantification of a humanized monoclonal anti-cocaine antibody. [PDF]

Biochem Biophys Rep
Webster RP, Kirley TL, Ray AR, Chan ZH, Norman AB.   +4 more
europepmc   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Monoclonal Antibodies: Historical Perspective and Current Trends in Biological Drug Development. [PDF]

Int J Mol Sci
Madej B, Tomaszewski F, Szmajda-Krygier D, Świechowski R, Jeleń A, Mirowski M.   +5 more
europepmc   +1 more source

Acute lymphoblastic B‐cell leukemia or CAR‐T cell related skin changes – a relevant diagnostic challenge

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Farzan Solimani, Amrei Dilling, Konrad Heisterkamp, Frederik Damm, Olaf Penack, Christian Oberender, Philipp Le‐Coutre, Martina Rudelius, Kamran Ghoreschi, Alexander Nast   +9 more
wiley   +1 more source

Integrative physiology of skeletal muscle for maintaining cognitive health

The Journal of Physiology, EarlyView.
Abstract figure legend Maintenance of brain/cognitive health and function is increasingly appreciated to be a systemic challenge. In particular, skeletal muscle influences the brain through release of myokines in response to contraction, which influence the expression of brain‐derived neurotrophic factor (BDNF) in the brain, a vital player in the ...
Matthew H. Brisendine, Joshua C. Drake
wiley   +1 more source

Mucin-1: a promising pan-cancer therapeutic target. [PDF]

NPJ Precis Oncol
Grewal US, Kurzrock R.
europepmc   +1 more source

Interaction between nuclear‐translocated cellular communication network factor 2 and purine‐rich box 1 regulates the expression of fibrosis‐related genes

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Although cellular communication network factor 2 (CCN2) is secreted out to the extracellular environment, intracellular CCN2 rather than re‐incorporated CCN2 from the outside may be involved in its translocation into the nuclei, because translocation of CCN2 into the nucleus was not disturbed by soluble heparin.
Xuan Thi Nguyen, Satoshi Kubota, Masaharu Takigawa, Takashi Nishida   +3 more
wiley   +1 more source

Acquired hemophilia due to immune checkpoint inhibitors: a case series introducing emicizumab treatment. [PDF]

Oncologist
Wolff L, Ertl C, Heinzerling L, Aspeslagh S, Verhaert M, Lattenist R, Confente C, Lambert C, Ilzkovitz M.   +8 more
europepmc   +1 more source