Results 91 to 100 of about 3,631,784 (211)

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Identification of murine haemopoietic stem cells with monoclonal antibodies [PDF]

, 1988
The work described in this thesis deals with the production and application of monoclonal antibodies to characterize murine haemopoietic stem cells.
Vries, P. (Peter) de
core   +1 more source

Inducible immortalized Dendritic Cells enable antigen-specific antibody production in a murine in vitro Immunization model.

PLoS ONE
Transferring the complexity of the in vivo immune response into a controlled in vitro system represents a promising strategy for the rapid generation of antigen-specific antibodies while significantly reducing the reliance on animal experimentation, thus
Juliane Egert, Natalia Maier, Burkhard Micheel, Katja Hanack   +3 more
doaj   +1 more source

Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment

Advanced Science, EarlyView.
Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang, Jiaqi He, Wan‐Ru Zhuang, Yao Lei, Yanru Jiang, Xianbin Ma, Pan Liu, Zhujun Jiang, Yongheng Li, Hai‐Yan Xie   +9 more
wiley   +1 more source

Multiple Tolerization Reduces Antibody Binding Against Tolerogen Cells: Implications for the Production of Monoclonal Antibodies

, 2018
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)CNPq: 425535/2016-9We report an immunization technique that can update the production of monoclonal antibodies (mAbs): the multiple tolerization subtractive immunization (MTSI).
Andrei Moroz, Julia Paiola da Silva, Da Silva, Julia Paiola [UNESP], Fusco-Almeida, Ana Marisa, Elenice Deffune, Da Silva, Julia Paiola, De Lima Fontes, Marina, Moroz, Andrei [UNESP], De Lima Fontes, Marina [UNESP], Marina de Lima Fontes, Nakamura, Cecília Naomi, Deffune, Elenice [UNESP], Cecília Naomi Nakamura, Deffune, Elenice, Matheus Bertanha, Bertanha, Matheus [UNESP], Ana Marisa Fusco-Almeida, Moroz, Andrei, Fusco-Almeida, Ana Marisa [UNESP], Nakamura, Cecília Naomi [UNESP], De Almeida, Rodrigo [UNESP], Bertanha, Matheus, De Almeida, Rodrigo, Rodrigo de Almeida   +23 more
core   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

Dual monoclonal antibody-based sandwich ELISA for detection of in vitro packaged Ebola virus

Diagnostic Pathology, 2018
Background Rapid transmission and high mortality of Ebola virus disease (EVD) highlight a urgent need of large scale, convenient and effective measure for Ebola virus screening. Application of monoclonal antibodies (mAbs) are crucial for establishment of
Junjie Zai, Kai Yi, Lilan Xie, Jiping Zhu, Xiaoting Feng, Yaoming Li   +5 more
doaj   +1 more source

Monoclonal antibodies for diagnosis of enterovirus 71

, 2014
[[abstract]]Enterovirus 71 (EV71), one of the major causative agents of hand, foot, and mouth disease (HFMD), is now recognized as an emerging neurotropic virus in Asia and may cause severe neurologic complications and mortalities.
Xu, L;Huang, KJ;Ho, TS;Liu, CC;Lee, YR;Lin, CY;Shiuan, D;Jiang, XH
core   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source