Results 81 to 90 of about 3,631,784 (211)

Monoclonal antibody against canine distemper virus H protein potently neutralizes the giant panda-derived strain

AMB Express
Canine distemper virus (CDV) is a multi-host pathogen with high morbidity and mortality, posing a severe threat to endangered carnivores, including giant pandas.
Yunli Li, Jianzhao Wu, Jiaqi Li, Jianhong Zeng, Lin Li, Xiaoyan Su, Jianzhong Wang, Xianzhu Xia, Rong Hou, Na Feng, Songrui Liu   +10 more
doaj   +1 more source

Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice

eLife
Pseudomonas aeruginosa (PA) is an opportunistic, frequently multidrug-resistant pathogen that can cause severe infections in hospitalized patients. Antibodies against the PA virulence factor, PcrV, protect from death and disease in a variety of animal ...
Malika Hale, Kennidy K Takehara, Christopher D Thouvenel, Dina A Moustafa, Andrea Repele, Mary F Fontana, Jason Netland, Sharon McNamara, Ronald L Gibson, Joanna B Goldberg, David J Rawlings, Marion Pepper   +11 more
doaj   +1 more source

Antibody-mediated neutralization of ACBP/DBI has anorexigenic and lipolytic effects

Adipocyte, 2020
We recently identified acyl coenzyme A-binding protein (ACBP)/diazepam binding inhibitor (DBI) as a novel ‘hunger factor’: a protein that is upregulated in human or murine obesity and that, if administered to mice, causes hyperphagy, adipogenesis and ...
Valentina Sica, Isabelle Martins, Omar Motiño, José M. Bravo-San Pedro, Guido Kroemer   +4 more
doaj   +1 more source

Sensitivity test of monoclonal antibodies Streptococcus mutans 1(c) 67 kDa [PDF]

, 2010
Background: Based on SKRT 2004, dental caries prevalence rate in Indonesia reached 90,05%. Local passive immunization with monoclonal antibodies is a new alternative in caries prevention.
Indah Listiana Kriswandini, Rizki Purnamasari Nugraheni, Anis Irmawati   +2 more
core   +1 more source

Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes [PDF]

, 2009
Anti-hepatitis C virus (HCV) cross-neutralizing human monoclonal antibodies, directed against conserved epitopes on surface E2 glycoprotein, are central tools for understanding virus-host interplay, and for planning strategies for prevention and ...
Patel, Ah, Ball Jonathan K., Nicasio Mancini, Nicola Clementi, Sautto, G, Clementi, N., Ball, J.K., Diotti, R.A., Burioni, R., Mario Perotti, Arvind H Patel, Nitti Giovanni, Diotti, Ra, Clementi Massimo, CLEMENTI, NICOLA, BURIONI, ROBERTO, Sautto, G., CLEMENTI, MASSIMO, Perotti, M., Jonathan K Ball, Massimo Clementi, Nitti, G, Giovanni Nitti, Patel, A.H., Clementi, M., Perotti Mario, Ball, Jk, Perotti, M, Patel Arvind H., Roberta A Diotti, Giuseppe Sautto, Mancini Nicasio, Diotti Roberta A., Mancini, N., Roberto Burioni, Sautto Giuseppe, MANCINI, NICASIO, Clementi Nicola, Burioni Roberto, Nitti, G.   +39 more
core   +1 more source

Sequential Patterning of Photoresponsive Hydrogels Directs Crypt Fission and Reveals the Role of Epithelial Curvature on Fission Symmetry

Advanced Science, EarlyView.
Deterministic crypt fission is achieved in intestinal organoids using photopatternable hydrogels with spatiotemporal control. Daughter‐crypt symmetry is shown to depend on parent‐crypt geometry and epithelial curvature, while myosin‐dependent mechanosensing links tissue shape to regenerative outcomes.
Delaney L. McNally, Kaustav Bera, Nolan R. Petrich, Alex Khang, Marilyne Coulombe, David Castillo‐Azofeifa, Ophir D. Klein, Peter J. Dempsey, Kristi S. Anseth   +8 more
wiley   +1 more source

Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis

Frontiers in Immunology, 2019
Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) target a wide range of modified proteins. Citrullination occurs during physiological processes such as apoptosis, yet little is known about the interaction of ACPA with
Katy A. Lloyd, Gustaf Wigerblad, Gustaf Wigerblad, Peter Sahlström, Peter Sahlström, Manasa G. Garimella, Karine Chemin, Johanna Steen, Philip J. Titcombe, Philip J. Titcombe, Bianka Marklein, Diana Zhou, Ragnhild Stålesen, Elena Ossipova, Christina Lundqvist, Olov Ekwall, Olov Ekwall, Johan Rönnelid, Daniel L. Mueller, Mikael C. I. Karlsson, Mariana J. Kaplan, Karl Skriner, Lars Klareskog, Fredrik Wermeling, Vivianne Malmström, Caroline Grönwall   +25 more
doaj   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Development of Foot-and-Mouth Disease Virus-Neutralizing Monoclonal Antibodies Derived From Plasmablasts of Infected Cattle and Their Germline Gene Usage

Frontiers in Immunology, 2019
Cattle are susceptible to foot-and-mouth disease virus (FMDV), and neutralizing antibodies are critical for protection against FMDV infection in this species.
Kun Li, Sheng Wang, Yimei Cao, Huifang Bao, Pinghua Li, Pu Sun, Xingwen Bai, Yuanfang Fu, Xueqing Ma, Jing Zhang, Dong Li, Yingli Chen, Xuerong Liu, Fanglan An, Faju Wu, Zengjun Lu, Zaixin Liu   +16 more
doaj   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source