Results 31 to 40 of about 3,631,784 (211)

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]

, 1993
The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
Brandt, M., Seißler, Jochen, Jungfer, Herbert, Eiermann, Thomas H., Wolfahrt, S., Endl, Josef, Scherbaum, Werner A., Richter, Wiltrud   +7 more
core   +1 more source

Engineering chimeric human and mouse major histocompatibility complex (MHC) class I tetramers for the production of T-cell receptor (TCR) mimic antibodies.

PLoS ONE, 2017
Therapeutic monoclonal antibodies targeting cell surface or secreted antigens are among the most effective classes of novel immunotherapies. However, the majority of human proteins and established cancer biomarkers are intracellular.
Demin Li, Carol Bentley, Jenna Yates, Maryam Salimi, Jenny Greig, Sarah Wiblin, Tasneem Hassanali, Alison H Banham   +7 more
doaj   +1 more source

The effect of enzymatically polymerised polyphenols on CD4 binding and cytokine production in murine splenocytes. [PDF]

PLoS ONE, 2012
High-molecular weight polymerised polyphenols have been shown to exhibit anti-influenza virus, anti-HIV, and anti-cancer activities. The purpose of this study was to evaluate the immunomodulating activities of enzymatically polymerised polyphenols, and ...
Daisuke Yamanaka, Yumi Tamiya, Masuro Motoi, Ken-ichi Ishibashi, Noriko N Miura, Yoshiyuki Adachi, Naohito Ohno   +6 more
doaj   +1 more source

Patient-Derived Antibody Data Yields Development of Broadly Cross-Protective Monoclonal Antibody against ST258 Carbapenem-Resistant Klebsiella pneumoniae

Microbiology Spectrum, 2022
The most pressing challenge for the development of anti-capsular antibodies is maximizing coverage against the heterogenous capsular polysaccharide (CPS) of carbapenem-resistant Klebsiella pneumoniae (CR-Kp).
Kasturi Banerjee, Michael P. Motley, Camila Boniche-Alfaro, Somanon Bhattacharya, Raj Shah, Andrew Ardizzone, Bettina C. Fries   +6 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Characterization of the major immediate-early polypeptides encoded by murine cytomegalovirus [PDF]

, 1985
The immediate-early (IE) infected cell proteins induced by the murine cytomegalovirus (Smith strain) were studied. These polypeptides were identified as IE proteins by their synthesis in the presence of actinomycin D after removal from a protein ...
Fibi, Mathias R., Koszinowski, Ulrich H., Keil, Günther M.   +2 more
core   +1 more source

Characterisation of two snake toxin-targeting human monoclonal immunoglobulin G antibodies expressed in tobacco plants. [PDF]

, 2023
Current snakebite antivenoms are based on polyclonal animal-derived antibodies, which can neutralize snake venom toxins in envenomed victims, but which are also associated with adverse reactions.
Adams, AC, Anna Christina Adams, Ljungars, A, Shirin Ahmadi, Dahl, Camilla Holst, Grav, Lise Marie, Moore, CM, Camilla Holst Dahl, Lise Marie Grav, Catherine M. Moore, Voldborg, BG, Laustsen, AH, Ma, Julian K-C, Anne Ljungars, Matthew J. Paul, Voldborg, Bjørn Gunnar, Moore, Catherine M., Paul, Matthew J., Andreas Hougaard Laustsen, Laustsen, Andreas Hougaard, Ahmadi, S, Grav, LM, Adams, Anna Christina, Bjørn Gunnar Voldborg, Julian K-C Ma, Ma, JK-C, Dahl, CH, Sanne Schoffelen, Schoffelen, S, Schoffelen, Sanne, Ahmadi, Shirin, Ljungars, Anne, Paul, MJ   +32 more
core   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Summary of screens for α-Jacob murine monoclonal antibodies.

, 2016
Summary of screens for α-Jacob murine monoclonal antibodies.
Carol A. Gilchrist (270735), Felicia K. Nguyen (2735716), Abdullah Siddique (165926), Lauren J. Spadafora (1338033), William A. Petri Jr. (165937), Tuhinur Arju (2735710), Benjamin Hoffstrom (2735713), Moira R. Kearney (2735704), Gerard A. Cangelosi (165934), Ibne K. Ali (2735707), Rashidul Haque (60045)   +10 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source