Results 31 to 40 of about 136,597 (121)

Shark Variable New Antigen Receptor (VNAR) Single Domain Antibody Fragments: Stability and Diagnostic Applications

Antibodies, 2013
The single variable new antigen receptor domain antibody fragments (VNARs) derived from shark immunoglobulin new antigen receptor antibodies (IgNARs) represent some of the smallest known immunoglobulin-based protein scaffolds.
Stewart Nuttall, Matthew A. Perugini, Iveth González, Joanne L. Casey, Abdulmonem Sanalla, Miles Barraclough, Con Dogovski, Julie Angerosa, Kathy Parisi, Olan Dolezal, Katherine Griffiths, Michael Foley   +11 more
doaj   +1 more source

Foreign or Domestic CARs: Receptor Ligands as Antigen-Binding Domains

Medical Sciences, 2014
Chimeric antigen receptors (CARs) are increasingly being used in clinical trials to treat a variety of malignant conditions and recent results with CD19-specific CARs showing complete tumor regressions has sparked the interest of researchers and the ...
Donald R. Shaffer, Penghui Zhou, Stephen Gottschalk   +2 more
doaj   +1 more source

Tetraplex Fluorescent Microbead-Based Immunoassay for the Serodiagnosis of Newcastle Disease Virus and Avian Influenza Viruses in Poultry Sera

Pathogens, 2022
Virulent Newcastle disease virus (NDV) as well as highly pathogenic avian influenza (HPAIV) subtypes H5 and H7 induce contagious and lethal systemic disease in poultry.
Na Zhao, Christian Grund, Martin Beer, Gang Wang, Timm C. Harder   +4 more
doaj   +1 more source

Idiotype vaccines produced with a non-cytopathic alphavirus self-amplifying RNA vector induce antitumor responses in a murine model of B-cell lymphoma

Scientific Reports, 2021
A promising therapy for patients with B-cell lymphoma is based on vaccination with idiotype monoclonal antibodies (mAbs). Since idiotypes are different in each tumor, a personalized vaccine has to be produced for each patient.
Erkuden Casales, Eva Martisova, Helena Villanueva, Ascensión López Díaz de Cerio, Susana Inoges, Noelia Silva-Pilipich, María Cristina Ballesteros-Briones, Alejandro Aranda, Jaione Bezunartea, Maurizio Bendandi, Fernando Pastor, Cristian Smerdou   +11 more
doaj   +1 more source

Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice

eLife
Pseudomonas aeruginosa (PA) is an opportunistic, frequently multidrug-resistant pathogen that can cause severe infections in hospitalized patients. Antibodies against the PA virulence factor, PcrV, protect from death and disease in a variety of animal ...
Malika Hale, Kennidy K Takehara, Christopher D Thouvenel, Dina A Moustafa, Andrea Repele, Mary F Fontana, Jason Netland, Sharon McNamara, Ronald L Gibson, Joanna B Goldberg, David J Rawlings, Marion Pepper   +11 more
doaj   +1 more source

Antibody-mediated neutralization of ACBP/DBI has anorexigenic and lipolytic effects

Adipocyte, 2020
We recently identified acyl coenzyme A-binding protein (ACBP)/diazepam binding inhibitor (DBI) as a novel ‘hunger factor’: a protein that is upregulated in human or murine obesity and that, if administered to mice, causes hyperphagy, adipogenesis and ...
Valentina Sica, Isabelle Martins, Omar Motiño, José M. Bravo-San Pedro, Guido Kroemer   +4 more
doaj   +1 more source

Monoclonal antibody against canine distemper virus H protein potently neutralizes the giant panda-derived strain

AMB Express
Canine distemper virus (CDV) is a multi-host pathogen with high morbidity and mortality, posing a severe threat to endangered carnivores, including giant pandas.
Yunli Li, Jianzhao Wu, Jiaqi Li, Jianhong Zeng, Lin Li, Xiaoyan Su, Jianzhong Wang, Xianzhu Xia, Rong Hou, Na Feng, Songrui Liu   +10 more
doaj   +1 more source

Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis

Frontiers in Immunology, 2019
Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) target a wide range of modified proteins. Citrullination occurs during physiological processes such as apoptosis, yet little is known about the interaction of ACPA with
Katy A. Lloyd, Gustaf Wigerblad, Gustaf Wigerblad, Peter Sahlström, Peter Sahlström, Manasa G. Garimella, Karine Chemin, Johanna Steen, Philip J. Titcombe, Philip J. Titcombe, Bianka Marklein, Diana Zhou, Ragnhild Stålesen, Elena Ossipova, Christina Lundqvist, Olov Ekwall, Olov Ekwall, Johan Rönnelid, Daniel L. Mueller, Mikael C. I. Karlsson, Mariana J. Kaplan, Karl Skriner, Lars Klareskog, Fredrik Wermeling, Vivianne Malmström, Caroline Grönwall   +25 more
doaj   +1 more source

Development of Foot-and-Mouth Disease Virus-Neutralizing Monoclonal Antibodies Derived From Plasmablasts of Infected Cattle and Their Germline Gene Usage

Frontiers in Immunology, 2019
Cattle are susceptible to foot-and-mouth disease virus (FMDV), and neutralizing antibodies are critical for protection against FMDV infection in this species.
Kun Li, Sheng Wang, Yimei Cao, Huifang Bao, Pinghua Li, Pu Sun, Xingwen Bai, Yuanfang Fu, Xueqing Ma, Jing Zhang, Dong Li, Yingli Chen, Xuerong Liu, Fanglan An, Faju Wu, Zengjun Lu, Zaixin Liu   +16 more
doaj   +1 more source

Dual monoclonal antibody-based sandwich ELISA for detection of in vitro packaged Ebola virus

Diagnostic Pathology, 2018
Background Rapid transmission and high mortality of Ebola virus disease (EVD) highlight a urgent need of large scale, convenient and effective measure for Ebola virus screening. Application of monoclonal antibodies (mAbs) are crucial for establishment of
Junjie Zai, Kai Yi, Lilan Xie, Jiping Zhu, Xiaoting Feng, Yaoming Li   +5 more
doaj   +1 more source