Results 41 to 50 of about 136,597 (121)

Development and Application of Mouse-Derived CD2v Monoclonal Antibodies Against African Swine Fever Virus from Single B Cells

Viruses
African swine fever (ASF) is a highly pathogenic and hemorrhagic swine infectious disease caused by the African swine fever virus (ASFV). It encodes over 150 proteins, among which the CD2v protein plays multiple roles throughout the infection process ...
Litao Yu, Fangtao Li, Xingqi Zou, Lu Xu, Junjie Zhao, Yan Li, Guorui Peng, Yingju Xia, Qizu Zhao, Yuanyuan Zhu   +9 more
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Humanization of Pan-HLA-DR mAb 44H10 Hinges on Critical Residues in the Antibody Framework

Antibodies
Reducing the immunogenicity of animal-derived monoclonal antibodies (mAbs) for use in humans is critical to maximize therapeutic effectiveness and preclude potential adverse events.
Audrey Kassardjian, Danton Ivanochko, Brian Barber, Arif Jetha, Jean-Philippe Julien   +4 more
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A novel fully human anti-ROR1 antibody PBA-0405 optimized for ADCC, induces potent anti-tumor activity against both solid and hematological malignancies

Frontiers in Immunology
IntroductionB-cell malignancies, including chronic lymphocytic leukemia (CLL), pose a significant clinical challenge due to high relapse rates and dose-limiting toxicities seen with current therapies, particularly in elderly patients.
Niina Veitonmäki, Anna Kostyn, Sonia Kołt, Aleksandra Ziemblicka, Beata Romanowska, Sabina Oleksy, Ewelina Krzywińska, Kamilla Sołtys, Łukasz Świderski, Piotr Naporowski, Piotr Mamczur, Monika Świtoń, Marek Orłowski, Marek Orłowski, Ying Zhang, Jianming Xu, Anna Andrzejczak, Aleksandra Bielawska-Pohl, Lidia Karabon, Dariusz Wołowiec, Wondossen Sime, Ramin Massoumi, Sameer Deshmukh, Jakub Kołodziejski, Tomasz Klaus, Pieter Spee   +25 more
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Rapid production of monoclonal antibodies from single mouse B cells against FMDV

Animal Diseases
Single B-cell antibody generation technology is an advanced method that offers several advantages, including rapid production, high efficiency, and high yield.
Zhengxin Yang, Fangtao Li, Mengjia Zhang, Yan Li, Qizu Zhao, Chunyan Wang, Lu Xu, Yebing Liu, Wentao Li, Yuanyuan Zhu   +9 more
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Inhibition of HER2 signaling and breast cancer cell growth with a novel antibody targeting HER2 ECD III/IV.

PLoS ONE
Human epidermal growth factor receptor 2 (HER2), a ligand-independent tyrosine kinase receptor belonging to the EGFR family, serves as a key oncogenic driver in breast, gastric, and several other solid tumors.
Chunchun Liu, Yulei Ren, Xuan Luo, Peiyun Zhou, Xiangjuan Du, Qianmin Wang, Xue Han, Yanhui Xu, Ping Wang, Dan Zhao, Huirong Yang   +10 more
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Prostaglandin F2 receptor negative regulator as a potential target for chimeric antigen receptor-T cell therapy for glioblastoma

Cancer Immunology, Immunotherapy
Background Chimeric antigen receptor (CAR)-T cell therapy targeting novel glioblastoma (GBM)-specific cell surface antigens is a promising approach. However, transcriptome analyses have revealed few GBM-specific target antigens.
Hideki Kuroda, Noriyuki Kijima, Tetsuro Tachi, Shunya Ikeda, Koki Murakami, Tomoyoshi Nakagawa, Moto Yaga, Kanji Nakagawa, Reina Utsugi, Ryuichi Hirayama, Yoshiko Okita, Naoki Kagawa, Naoki Hosen, Haruhiko Kishima   +13 more
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T-cell responses against CD19-targeted CAR T cells varnimcabtagene autoleucel (ARI-0001): implications for immune response and therapy outcomes

Journal for ImmunoTherapy of Cancer
Patients with B-cell malignancies receiving CD19-targeted chimeric antigen receptor (CAR) T-cell therapy may experience treatment failure due to various mechanisms.
Manel Juan, Alvaro Urbano-Ispizua, Eddie James, William W Kwok, Susana Rives, Valentín Ortiz-Maldonado, Anna Alonso-Saladrigues, Julio Delgado, Europa Azucena González-Navarro, Ariadna Bartoló-Ibars, Andrea Aran, Alexandra M Johansson, Nela Klein-González   +12 more
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Priming VRC01-precursor B cells with non-envelope immunogens disfavors boosting with HIV-1 envelope

npj Vaccines
VRC01-class antibodies are a genetically restricted class of antibodies capable of potently neutralizing diverse strains of HIV-1. Unmutated VRC01 precursors fail to recognize recombinant HIV-1 Envelope (Env) proteins, which necessitated the development ...
Andrew Wilcox-King, Yu-Hsin Wan, Samuel C. Scharffenberger, Crystal B. Chhan, Amelia R. Davis, Leah J. Homad, Emilie Seydoux, Kellie J. MacPhee, Latha Kallur Siddaramaiah, Mariane Melo, Pia Dosenovic, Darrell J. Irvine, Ollivier Hyrien, Leonidas Stamatatos, Andrew T. McGuire   +14 more
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Nidogen 1-enriched extracellular vesicles promote liver metastasis by inducing EMT and activating stellate cells

iScience
Summary: The liver is frequently affected by metastasis in colorectal cancer patients; however, the precise interaction between the liver microenvironment and metastatic colorectal cancer cells remains elusive.
Haipeng Chen, Hengchang Liu, Lin Wang, Jialiang Liu, Tianli Chen, You Zuo, Hanqing Hu, Xishan Wang, Guiyu Wang   +8 more
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Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Advanced Science
The tumor microenvironment promotes cancer progression in part by supporting cancer stem cells (CSC). In colorectal cancer (CRC), progastrin (PG), an orphan growth factor secreted by tumor cells within the tumor and its microenvironment, maintains CSCs ...
Julie Nguyen, Marie Lafitte, Maud Barbery, Kevin Espie, Maya Jeitany, Romain Larive, Jihane Vitre, Conception Paul, Yvan Boublik, Elise Fourgous, Valérie Simon, Audrey Sirvent, Madeline Neiveyans, Steeve Thirard, Lucile Bansard, Morgan Maillard, Nathalie Coutry, Jacques Colinge, Philippe Jay, Pierre Martineau, Michael Hahne, Julie Pannequin, Serge Roche   +22 more
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