Results 21 to 30 of about 136,597 (121)

A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum.

PLoS Pathogens, 2022
Potent and durable vaccine responses will be required for control of malaria caused by Plasmodium falciparum (Pf). RTS,S/AS01 is the first, and to date, the only vaccine that has demonstrated significant reduction of clinical and severe malaria in ...
Nathan Beutler, Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Randall S MacGill, Elijah Garcia, Jaeson Calla, Mara Parren, Linlin Yang, Wayne Volkmuth, Emily Locke, Jason A Regules, Sheetij Dutta, Daniel Emerling, Angela M Early, Daniel E Neafsey, Elizabeth A Winzeler, C Richter King, Fidel Zavala, Dennis R Burton, Ian A Wilson, Thomas F Rogers   +21 more
doaj   +1 more source

Antibodies to antigenic site A of influenza H7 hemagglutinin provide protection against H7N9 challenge.

PLoS ONE, 2015
Identifying major antigenic and protective epitopes of the H7 hemagglutinin (HA) will be important for understanding the antibody response to vaccines developed against the novel influenza H7N9 viruses that emerged in China in 2013.
Falko Schmeisser, Anupama Vasudevan, Swati Verma, Wei Wang, Esmeralda Alvarado, Carol Weiss, Vajini Atukorale, Clement Meseda, Jerry P Weir   +8 more
doaj   +1 more source

Rebmab200, a humanized monoclonal antibody targeting the sodium phosphate transporter NaPi2b displays strong immune mediated cytotoxicity against cancer: a novel reagent for targeted antibody therapy of cancer.

PLoS ONE, 2013
NaPi2b, a sodium-dependent phosphate transporter, is highly expressed in ovarian carcinomas and is recognized by the murine monoclonal antibody MX35. The antibody had shown excellent targeting to ovarian cancer in several early phase clinical trials but ...
Mariana Lopes dos Santos, Fernanda Perez Yeda, Lilian Rumi Tsuruta, Bruno Brasil Horta, Alécio A Pimenta, Theri Leica Degaki, Ibere C Soares, Maria Carolina Tuma, Oswaldo Keith Okamoto, Venancio A F Alves, Lloyd J Old, Gerd Ritter, Ana Maria Moro   +12 more
doaj   +1 more source

Alpha‐Klotho, a critical protein for lung health, is not expressed in normal lung

FASEB BioAdvances, 2019
Alpha‐Klotho (αKlotho), produced by the kidney and selected organs, is essential for tissue maintenance and protection. Homozygous αKlotho‐deficiency leads to premature multi‐organ degeneration and death; heterozygous insufficiency leads to apoptosis ...
Jianning Zhang, Khoa Cao, Johanne V. Pastor, Liping Li, Orson W. Moe, Connie C. W. Hsia   +5 more
doaj   +1 more source

Engineering chimeric human and mouse major histocompatibility complex (MHC) class I tetramers for the production of T-cell receptor (TCR) mimic antibodies.

PLoS ONE, 2017
Therapeutic monoclonal antibodies targeting cell surface or secreted antigens are among the most effective classes of novel immunotherapies. However, the majority of human proteins and established cancer biomarkers are intracellular.
Demin Li, Carol Bentley, Jenna Yates, Maryam Salimi, Jenny Greig, Sarah Wiblin, Tasneem Hassanali, Alison H Banham   +7 more
doaj   +1 more source

The effect of enzymatically polymerised polyphenols on CD4 binding and cytokine production in murine splenocytes. [PDF]

PLoS ONE, 2012
High-molecular weight polymerised polyphenols have been shown to exhibit anti-influenza virus, anti-HIV, and anti-cancer activities. The purpose of this study was to evaluate the immunomodulating activities of enzymatically polymerised polyphenols, and ...
Daisuke Yamanaka, Yumi Tamiya, Masuro Motoi, Ken-ichi Ishibashi, Noriko N Miura, Yoshiyuki Adachi, Naohito Ohno   +6 more
doaj   +1 more source

Patient-Derived Antibody Data Yields Development of Broadly Cross-Protective Monoclonal Antibody against ST258 Carbapenem-Resistant Klebsiella pneumoniae

Microbiology Spectrum, 2022
The most pressing challenge for the development of anti-capsular antibodies is maximizing coverage against the heterogenous capsular polysaccharide (CPS) of carbapenem-resistant Klebsiella pneumoniae (CR-Kp).
Kasturi Banerjee, Michael P. Motley, Camila Boniche-Alfaro, Somanon Bhattacharya, Raj Shah, Andrew Ardizzone, Bettina C. Fries   +6 more
doaj   +1 more source

L2pB1 Cells Contribute to Tumor Growth Inhibition

Frontiers in Immunology, 2021
Natural IgM (nIgM) antibodies play critical roles in cancer immunosurveillance. However, the role of B-1 B cells, the lymphocytes that produce nIgM, remains to be elucidated.
Varuna Shibad, Ali Bootwala, Changchuin Mao, Changchuin Mao, Hanna Bader, Hung Vo, Esther Landesman-Bollag, Conrad Guo, Angel Rubio, Richard Near, Richard Near, Wenda Gao, Sreekar Challa, Vennela Chukka, Jeffrey Gao, Avery Kelly, Tamar Landesman, Tyler VanHelene, Xuemei Zhong   +18 more
doaj   +1 more source

Dengue Virus Envelope Dimer Epitope Monoclonal Antibodies Isolated from Dengue Patients Are Protective against Zika Virus

mBio, 2016
Zika virus (ZIKV) is a mosquito-borne flavivirus responsible for thousands of cases of severe fetal malformations and neurological disease since its introduction to Brazil in 2013.
J. A. Swanstrom, J. A. Plante, K. S. Plante, E. F. Young, E. McGowan, E. N. Gallichotte, D. G. Widman, M. T. Heise, A. M. de Silva, R. S. Baric   +9 more
doaj   +1 more source

Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies

Frontiers in Immunology, 2019
4-1BB (CD137) is an inducible costimulatory receptor that promotes expansion and survival of activated T cells; and IgG-based 4-1BB-agonistic monoclonal antibodies exhibited potent antitumor activity in clinical trials.
Kasper Mikkelsen, Seandean Lykke Harwood, Marta Compte, Nekane Merino, Kasper Mølgaard, Simon Lykkemark, Ana Alvarez-Mendez, Francisco J. Blanco, Francisco J. Blanco, Luis Álvarez-Vallina, Luis Álvarez-Vallina, Luis Álvarez-Vallina   +11 more
doaj   +1 more source