Results 21 to 30 of about 236,432 (265)

Production and N-glycan engineering of Varlilumab in Nicotiana benthamiana

Frontiers in Plant Science, 2023
N-glycan engineering has dramatically evolved for the development and quality control of recombinant antibodies. Fc region of IgG contains two N-glycans whose galactose terminals on Fc-glycan have been shown to increase the stability of CH2 domain and ...
Kim Dua Nguyen, Hiroyuki Kajiura, Hiroyuki Kajiura, Ryo Kamiya, Takahiro Yoshida, Ryo Misaki, Ryo Misaki, Kazuhito Fujiyama, Kazuhito Fujiyama, Kazuhito Fujiyama   +9 more
doaj   +1 more source

Lipid nanoparticle delivery of unmodified mRNAs encoding multiple monoclonal antibodies targeting poxviruses in rabbits

Molecular Therapy: Nucleic Acids, 2022
Poxviruses are a large and complex family of viruses with members such as monkeypox virus and variola virus. The possibility of an outbreak of monkeypox virus (or a related poxvirus) or the misuse of variola virus justifies the development of ...
Eric M. Mucker, Carolin Thiele-Suess, Patrick Baumhof, Jay W. Hooper   +3 more
doaj   +1 more source

Serologic characterization of anti-protamine/heparin and anti-PF4/heparin antibodies

Blood Advances, 2017
: Anti-protamine (PRT)/heparin antibodies are a newly described class of heparin-dependent antibodies occurring in patients exposed to PRT and heparin during cardiac surgery.
Grace M. Lee, Manali Joglekar, Maragatha Kuchibhatla, Sanjay Khandelwal, Rui Qi, Lubica Rauova, Gowthami M. Arepally   +6 more
doaj   +1 more source

Constitutive overexpression of a novel 21 kDa protein by Hodgkin Lymphoma and Aggressive Non-Hodgkin Lymphomas

Molecular Cancer, 2008
Background CD30, a 120 kDa surface phosphorylated protein is a member of tumour necrosis/nerve growth factor receptor (TNF/NGFR) family and constitutively expressed by Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin lymphoma (HL) and the neoplastic ...
Gascoyne Randy D, Skinnider Brian, Cohn Jason B, Fadlelmola Faisal M, Zhou Minglong, Banerjee Diponkar   +5 more
doaj   +1 more source

Bispecific antibodies and their use in applied research

Veterinary World, 2012
Bispecific antibodies (BsAb) can, by virtue of combining two binding specificities, improve the selectivity and efficacy of antibody-based treatment of human disease.
Harshit Verma, Durairajan Ramachandran, Ashabaree Samal   +2 more
doaj   +1 more source

Monoclonal antibodies against peptidorhamnomannans of Scedosporium apiospermum enhance the pathogenicity of the fungus. [PDF]

PLoS Neglected Tropical Diseases, 2010
Scedosporium apiospermum is part of the Pseudallescheria-Scedosporium complex. Peptidorhamnomannans (PRMs) are cell wall glycopeptides present in some fungi, and their structures have been characterized in S. apiospermum, S.
Livia C L Lopes, Rodrigo Rollin-Pinheiro, Allan J Guimarães, Vera C B Bittencourt, Luis R Martinez, Wade Koba, Sandra E Farias, Joshua D Nosanchuk, Eliana Barreto-Bergter   +8 more
doaj   +1 more source

Monoclonal antibody against canine distemper virus H protein potently neutralizes the giant panda-derived strain. [PDF]

AMB Express
Canine distemper virus (CDV) is a multi-host pathogen with high morbidity and mortality, posing a severe threat to endangered carnivores, including giant pandas.
Li Y, Wu J, Li J, Zeng J, Li L, Su X, Wang J, Xia X, Hou R, Feng N, Liu S.   +10 more
europepmc   +2 more sources

Proinflammatory Action of a New Electronegative Low-Density Lipoprotein Epitope

Biomolecules, 2019
The electronegative low-density lipoprotein, LDL (−), is an endogenously modified LDL subfraction with cytotoxic and proinflammatory actions on endothelial cells, monocytes, and macrophages contributing to the progression of atherosclerosis.
Tanize do Espirito Santo Faulin, Soraya Megumi Kazuma, Gustavo Luis Tripodi, Marcela Frota Cavalcante, Felipe Wakasuqui, Cristiano Luis Pinto Oliveira, Maximilia Frazão de Souza Degenhardt, Jussara Michaloski, Ricardo José Giordano, Daniel Francisco Jacon Ketelhuth, Dulcineia Saes Parra Abdalla   +10 more
doaj   +1 more source

Development of ELISA test for the quality control of Pseudomonas aeruginosa recombinant vaccine based on the hybrid recombinant protein

Медицинская иммунология, 2020
A hybrid recombinant protein containing the amino  acid sequences of the three  most significant Pseudomonas aeruginosa antigens  (membrane proteins OprF, OprI  and toxoid  aTox)  was incorporated into a vaccine against Pseudomonas infection.
A. V. Soldatenkova, A. M. Kudryashova, N. F. Gavrilova, I. V. Yakovleva, O. V. Borisova, V. V. Sviridov, N. A. Mikhailova   +6 more
doaj   +1 more source

Production and characterisation of monoclonal antibodies for the detection of AOZ, a tissue bound metabolite of furazolidone

Veterinární Medicína, 2005
3-amino-2-oxazolidinone (AOZ) is a tissue bound toxic metabolite derived from the nitrofuran antibiotic, furazolidone. AOZ is detected in the derivatised form of 3-{[(2-nitrophenyl) methylene] amino}-2-oxa-zolidinone (NP AOZ).
M. Vass, L. Kotkova, I. Diblikova, Z. Nevorankova, K.M. Cooper, D.G. Kennedy, M. Franek   +6 more
doaj   +1 more source