Results 41 to 50 of about 245,259 (243)

Antibodies to antigenic site A of influenza H7 hemagglutinin provide protection against H7N9 challenge.

PLoS ONE, 2015
Identifying major antigenic and protective epitopes of the H7 hemagglutinin (HA) will be important for understanding the antibody response to vaccines developed against the novel influenza H7N9 viruses that emerged in China in 2013.
Falko Schmeisser, Anupama Vasudevan, Swati Verma, Wei Wang, Esmeralda Alvarado, Carol Weiss, Vajini Atukorale, Clement Meseda, Jerry P Weir   +8 more
doaj   +1 more source

Patient-Derived Antibody Data Yields Development of Broadly Cross-Protective Monoclonal Antibody against ST258 Carbapenem-Resistant Klebsiella pneumoniae

Microbiology Spectrum, 2022
The most pressing challenge for the development of anti-capsular antibodies is maximizing coverage against the heterogenous capsular polysaccharide (CPS) of carbapenem-resistant Klebsiella pneumoniae (CR-Kp).
Kasturi Banerjee, Michael P. Motley, Camila Boniche-Alfaro, Somanon Bhattacharya, Raj Shah, Andrew Ardizzone, Bettina C. Fries   +6 more
doaj   +1 more source

Costimulatory molecule-deficient dendritic cell progenitors (MHC class II⁺, CD80(dim), CD86^-) prolong cardiac allograft survival in nonimmunosuppressed recipients [PDF]

, 1996
We have shown previously that granulocyte-macrophage colony-stimulating factor-stimulated mouse bone marrow-derived MHC class II+ dendritic cell (DC) progenitors that are deficient in cell surface expression of the costimulatory molecules B7-1 (CD8O) and
Angus W. Thomson, Azuma, Boussiotis, Boussiotis, Clare-Salzler, Demetris, Frances Chambers, Freeman, Freeman, Fumin Fu, Gimmi, Go, Hathcock, Inaba, Inaba, Inaba, Jenkins, Jenkinson, John J. Fung, Khoury, Kraal, Larsen, Lin, Lina Lu, Linsley, Lu, Lu, Lu, Lu, Matzinger, Pearson, Qian, Rastellini, Reis e Sousa, Sakamoto, Sayegh, Shiguang Qian, Starzl, Starzl, Steinman, Swiggard, Talmor, Taniguchi, Thomas E. Starzl, Thomson, Turka, Van Gool, Woo, Youping Li   +48 more
core   +1 more source

Rebmab200, a humanized monoclonal antibody targeting the sodium phosphate transporter NaPi2b displays strong immune mediated cytotoxicity against cancer: a novel reagent for targeted antibody therapy of cancer.

PLoS ONE, 2013
NaPi2b, a sodium-dependent phosphate transporter, is highly expressed in ovarian carcinomas and is recognized by the murine monoclonal antibody MX35. The antibody had shown excellent targeting to ovarian cancer in several early phase clinical trials but ...
Mariana Lopes dos Santos, Fernanda Perez Yeda, Lilian Rumi Tsuruta, Bruno Brasil Horta, Alécio A Pimenta, Theri Leica Degaki, Ibere C Soares, Maria Carolina Tuma, Oswaldo Keith Okamoto, Venancio A F Alves, Lloyd J Old, Gerd Ritter, Ana Maria Moro   +12 more
doaj   +1 more source

The effect of enzymatically polymerised polyphenols on CD4 binding and cytokine production in murine splenocytes. [PDF]

PLoS ONE, 2012
High-molecular weight polymerised polyphenols have been shown to exhibit anti-influenza virus, anti-HIV, and anti-cancer activities. The purpose of this study was to evaluate the immunomodulating activities of enzymatically polymerised polyphenols, and ...
Daisuke Yamanaka, Yumi Tamiya, Masuro Motoi, Ken-ichi Ishibashi, Noriko N Miura, Yoshiyuki Adachi, Naohito Ohno   +6 more
doaj   +1 more source

Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]

, 2005
Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Huss, R., Hutter, J., Krombach, F., Moosmann, S., Moser, C.   +4 more
core   +1 more source

Alpha‐Klotho, a critical protein for lung health, is not expressed in normal lung

FASEB BioAdvances, 2019
Alpha‐Klotho (αKlotho), produced by the kidney and selected organs, is essential for tissue maintenance and protection. Homozygous αKlotho‐deficiency leads to premature multi‐organ degeneration and death; heterozygous insufficiency leads to apoptosis ...
Jianning Zhang, Khoa Cao, Johanne V. Pastor, Liping Li, Orson W. Moe, Connie C. W. Hsia   +5 more
doaj   +1 more source

Engineering chimeric human and mouse major histocompatibility complex (MHC) class I tetramers for the production of T-cell receptor (TCR) mimic antibodies.

PLoS ONE, 2017
Therapeutic monoclonal antibodies targeting cell surface or secreted antigens are among the most effective classes of novel immunotherapies. However, the majority of human proteins and established cancer biomarkers are intracellular.
Demin Li, Carol Bentley, Jenna Yates, Maryam Salimi, Jenny Greig, Sarah Wiblin, Tasneem Hassanali, Alison H Banham   +7 more
doaj   +1 more source

In Vivo Fluorescence Imaging of E-Selectin: Quantitative Detection of Endothelial Activation in Arthritis [PDF]

, 2010
Rheumatoid arthritis (RA) is a chronic progressive systemic inflammatory disease, characterized by synovial inflammation and localized destruction of cartilage and bone.
Gompels, Luke, Gompels, Luke
core   +1 more source

L2pB1 Cells Contribute to Tumor Growth Inhibition

Frontiers in Immunology, 2021
Natural IgM (nIgM) antibodies play critical roles in cancer immunosurveillance. However, the role of B-1 B cells, the lymphocytes that produce nIgM, remains to be elucidated.
Varuna Shibad, Ali Bootwala, Changchuin Mao, Changchuin Mao, Hanna Bader, Hung Vo, Esther Landesman-Bollag, Conrad Guo, Angel Rubio, Richard Near, Richard Near, Wenda Gao, Sreekar Challa, Vennela Chukka, Jeffrey Gao, Avery Kelly, Tamar Landesman, Tyler VanHelene, Xuemei Zhong   +18 more
doaj   +1 more source