Results 231 to 240 of about 1,274,843 (306)

Comparative Real-World Outcomes of OnabotulinumtoxinA and CGRP Monoclonal Antibodies in Chronic Migraine. [PDF]

J Clin Med
Lin CF, Chung CC, Chen JH, Chi NF, Hu CJ, Huang HE, Chen CC, Yeh TH, Wei JC, Lee HH.   +9 more
europepmc   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

A Narrative Review of Amyloid-β Monoclonal Antibodies for Alzheimer Disease: How Amyloid Species Engagement May Affect Clinical Outcomes. [PDF]

Neurologist
Caselli RJ, Geldmacher DS, Schilling TB.
europepmc   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Change in COVID-19 outcomes in lymphoma patients across pandemic waves: results of the COVID-19-lymphoma registry of the Bavarian Cancer Research Center (BZKF) 2020-2022. [PDF]

Ann Hematol
Forkl S, Freudenberger F, Jacobs B, Einhell S, Hirschbuehl K, Claus R, Hellwig D, Mougiakakos D, Dreyling M, Illert L, Heidegger S, Weigert O, Hellmuth JC.   +12 more
europepmc   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Protective and Pathogenic Antibodies to Citrullinated Antigens. [PDF]

Immunol Rev
Sareila O, He Y, Xu Z, Ge C, Lönnblom E, Holmdahl R.   +5 more
europepmc   +1 more source

Cross-Species Reactivity and Differential Anti-PRRSV Activities of CD163 SRCR4/SRCR5 Monoclonal Antibodies. [PDF]

Vet Sci
Meng Y, Yang S, Jiao J, Zhang P, Guan Q, Lin Y, Cui M, Wang X, Zhu X, Qiu M, Lin H, Zheng W, Zhu J, Stoian AMM, Fraile L, Chen N.   +15 more
europepmc   +1 more source

Development of JEV NS1 Specific Capture-ELISA Based on a Single Monoclonal Antibody. [PDF]

Animals (Basel)
Zhang SJ, Zhang JH, Liu SM, Huang YT, Wang JL, Bu ZG, Hua RH.   +6 more
europepmc   +1 more source

MuSK myasthenia gravis: from antigen-antibody to clinical translation. [PDF]

Front Immunol
Zhou X, Zhang J, Dong H, Cui X, Zhang H, Zhang M, Liu R, Liu Q, Hu J, Liu J, Zhang Y, Zhao X, Chang T, Ruan Z, Yang J, Lv J, Gao F.   +16 more
europepmc   +1 more source