Results 261 to 270 of about 2,105,900 (288)
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An Overview of Monoclonal Antibodies
Seminars in Oncology Nursing, 2019To provide a brief overview of the development of monoclonal antibodies in immunotherapy, including a review of the mechanism of action and types, and indications for use.Peer-reviewed journal articles, book chapters, internet.Monoclonal antibodies offer alternative treatment to cancer patients who have failed or progressed on standard chemotherapy ...
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Molecular and Cellular Biochemistry, 1984
The technology for the production of murine monoclonal antibodies has been refined enormously since its introduction in 1975. However, the technology for generating human monoclonal antibodies has only recently come into its own. In this review, three currently available approaches to the production of human monoclonal antibodies are described.
D. Kozbor +4 more
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The technology for the production of murine monoclonal antibodies has been refined enormously since its introduction in 1975. However, the technology for generating human monoclonal antibodies has only recently come into its own. In this review, three currently available approaches to the production of human monoclonal antibodies are described.
D. Kozbor +4 more
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Deimmunization of Monoclonal Antibodies
2008Immunogenicity is a major limitation to therapy with certain monoclonal antibodies and proteins. A major driver for immunogenicity is the presence of human T-cell epitopes within the protein sequence which can activate helper T-cells resulting in the sustained production of antibodies and neutralization of the therapeutic effect.
Laura J. Crompton +3 more
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Monoclonal antibodies in haematology
Blood Reviews, 1989The development of methods for the production of monoclonal antibodies is having an important impact in the field of immunohaematology. Four separate areas are implicated. First, there is the use of monoclonal antibodies in blood transfusion, where antibodies within the ABO, Rh, Lewis, P, MN, Kell and Lutheran systems are available.
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Radiolabeling of Monoclonal Antibodies
2000Radiolabeling of monoclonal antibodies (mAbs) is often one of the principal methods for the in vitro and in vivo assessment of these reagents, whether this is determining the affinity of a new reagent, preparing for preclinical testing, or clinically for diagnostic or therapeutic use.
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