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Monoclonal Antibodies: A Review
Current Clinical Pharmacology, 2018Over the last three decades, monoclonal antibodies (MAbs) have made a striking transformation from scientific tools to powerful human therapeutics. Muromonab CD3 a murine MAb was the first FDA approved therapeutic MAb for the prevention of kidney transplant rejection.
Preeti Sidhu +6 more
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New England Journal of Medicine, 1981
Serologic reagents have played an important role in the diagnosis, treatment, and epidemiology of infectious diseases. A new technology has been developed for generating homogeneous antibodies that can be produced in large amounts and are available indefinitely. This technique promises to increase the reliability and sensitivity of immunoassays and may
M D, Scharff, S, Roberts, P, Thammana
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Serologic reagents have played an important role in the diagnosis, treatment, and epidemiology of infectious diseases. A new technology has been developed for generating homogeneous antibodies that can be produced in large amounts and are available indefinitely. This technique promises to increase the reliability and sensitivity of immunoassays and may
M D, Scharff, S, Roberts, P, Thammana
openaire +4 more sources
Production of Monoclonal Antibodies [PDF]
Current Protocols in Immunology, 1992 AbstractThis unit describes the production of monoclonal antibodies beginning with immunization, cell fusion, and selection. Support protocols are provided for screening primary hybridoma supernatants for antibodies of desired specificity, establishment of stable hybridoma lines, cloning of these B cell lines by limiting dilution to obtain monoclonal ...
Wayne M, Yokoyama +7 more
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2008
Monoclonal antibodies (mabs) are powerful tools for the quantification, detection, and targeting of specific molecules. Allergen-specific mabs are important for the quantification of major allergens in allergen preparations used for allergen-specific immunotherapy and allergy diagnosis.
Helga, Kahlert, Oliver, Cromwell
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Monoclonal antibodies (mabs) are powerful tools for the quantification, detection, and targeting of specific molecules. Allergen-specific mabs are important for the quantification of major allergens in allergen preparations used for allergen-specific immunotherapy and allergy diagnosis.
Helga, Kahlert, Oliver, Cromwell
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Monoclonal Antibodies to Benzodiazepines
Journal of Neurochemistry, 1985Abstract: Four hybridoma lines secreting monoclonal antibodies to benzodiazepines were produced after BALB/c mice were immunized with a benzodiazepine‐bovine serum albumin conjugate. The monoclonal antibodies were purified from ascites fluids, and their binding affinities for benzodiazepines and other benzodiazepine receptor ligands were determined ...
A L, De Blas +5 more
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Antibodies and Selection of Monoclonal Antibodies
2015Monoclonal antibodies are universal binding molecules with a high specificity for their target and are indispensable tools in research, diagnostics and therapy. The biotechnological generation of monoclonal antibodies was enabled by the hybridoma technology published in 1975 by Köhler and Milstein.
Katrin Messerschmidt +2 more
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