Results 111 to 120 of about 3,666,403 (333)

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Nature Communications, 2019
Lee et al. report an engineered IgG1 Fc domain that behaves like an hFcRn binding pH toggle switch. The authors show that this new half-life extension Fc domain confers improved pharmacokinetics in new humanized knock-in mouse strains that recapitulate ...
Chang-Han Lee, Tae Hyun Kang, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M. Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E. Macdonald, Andrew J. Murphy, Naxin Tu, Jiwon Lee, Jonathan R. McDaniel, Emily Makowski, Peter M. Tessier, Aaron S. Meyer, Pierre Bruhns, George Georgiou   +18 more
doaj   +1 more source

Sero-Prevalence and Factors Associated with Toxoplasma gondii Infection among Pregnant Women Attending Antenatal Care in Mwanza, Tanzania. [PDF]

, 2013
Serological screening of pregnant women for Toxoplasma gondii-specific antibodies is not practiced as an antenatal care in Tanzania; and there is a limited data about sero-prevalence of T. gondii infection in developing countries.
Groß, Uwe, Kidenya, Benson R, Majinge, Charles, Massinde, Anthony N, Mazigo, Humphrey D, Michael, Denna, Mshana, Stephen E, Mwambe, Berno   +7 more
core   +2 more sources

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody [PDF]

, 2020
Xiaolong Tian, Cheng Li, Ailing Huang, Shuai Xia, Sicong Lu, Zheng‐Li Shi, Lu Lu, Shibo Jiang, Zhenlin Yang, Yanling Wu, Tianlei Ying   +10 more
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Rat Monoclonal Antibodies Specific for LST1 Proteins [PDF]

, 2009
The LST1 gene is located in the human MHC class III region and encodes transmembrane and soluble isoforms that have been suggested to play a role in the regulation of the immune response and are associated with inflammatory diseases such as rheumatoid ...
Kremmer, Elisabeth, Nitschké, Maximilian J. E., Schiller, Christian, Seidl, Alexander, Weiss, Elisabeth H.   +4 more
core   +1 more source

Characterization of SARS-CoV-2 RNA, Antibodies, and Neutralizing Capacity in Milk Produced by Women with COVID-19

, 2021
Ryan M. Pace, Janet E. Williams, Kirsi M. Järvinen, Mandy B. Belfort, Christina D. W. Pace, Kimberly A. Lackey, Alexandra C. Gogel, Phuong Nguyen‐Contant, Preshetha Kanagaiah, Theresa Fitzgerald, Rita Ferri, Bridget E. Young, Casey Rosen‐Carole, Nichole Diaz, Courtney L. Meehan, Beatrice Caffé, Mark Y. Sangster, David J. Topham, Mark A. McGuire, Antti Seppo, Shelley McGuire   +20 more
openalex   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Antibody and Antibody Mimetic Immunotherapeutics [PDF]

Future Medicinal Chemistry, 2017
Angeline N, Ta, Brian R, McNaughton
openaire   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein

Fluids and Barriers of the CNS
Background Therapeutic antibodies for the treatment of neurological disease show great potential, but their applications are rather limited due to limited brain exposure.
Marie-Lynn Cuypers, Tom Jaspers, Jarne Clerckx, Simon Leekens, Christopher Cawthorne, Guy Bormans, Frederik Cleeren, Nick Geukens, Bart De Strooper, Maarten Dewilde   +9 more
doaj   +1 more source