Results 111 to 120 of about 5,065,448 (337)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Thoracic duct fistula and renal transplantation [PDF]

, 1979
Thoracic duct drainage (TDD) was established for 21-115 days in 40 kidney recipients with an average removal per patient day of 4.7 1 lymph and 1.88 billion cells. Cellular and humoral immunity were depressed. TDD and immunosuppressive drugs were started
Franks, JJ, Halgrimson, CG, Iwaki, Y, Koep, LJ, McCalmon, RT, Schröter, GP, Starzl, TE, Subryan, V, Terasaki, PI, Weil, R   +9 more
core   +2 more sources

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Nature, 2021
Zijun Wang, F. Schmidt, Y. Weisblum, F. Muecksch, C. Barnes, Shlomo Finkin, Dennis J. Schaefer-Babajew, M. Cipolla, C. Gaebler, J. Lieberman, Thiago Y. Oliveira, Zhi Yang, M. Abernathy, Kathryn E Huey-Tubman, A. Hurley, Martina Turroja, K. West, Kristie M Gordon, Katrina G. Millard, Victor Ramos, Justin Da Silva, Jianliang Xu, R. Colbert, R. Patel, Juan P Dizon, Cecille Unson-O’Brien, I. Shimeliovich, A. Gazumyan, M. Caskey, P. Bjorkman, R. Casellas, T. Hatziioannou, P. Bieniasz, M. Nussenzweig   +33 more
semanticscholar   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Unveiling novel insights into human IL-6 − IL-6R interaction sites through 3D computer-guided docking and systematic site mutagenesis

Scientific Reports
The cytokine interleukin-6 (IL-6) plays a crucial role in autoimmune and inflammatory diseases. Understanding the precise mechanism of IL-6 interaction at the amino acid level is essential to develop IL-6-inhibiting compounds.
Kaitong Li, Junyu Cai, Zhiyang Jiang, Qingbin Meng, Zhao Meng, He Xiao, Guojiang Chen, Chunxia Qiao, Longlong Luo, Jijun Yu, Xinying Li, Yinxiang Wei, Hui Li, Chenghua Liu, Beifen Shen, Jing Wang, Jiannan Feng   +16 more
doaj   +1 more source

Distinguishing features of cetuximab and panitumumab in colorectal cancer and other solid tumors [PDF]

, 2019
Cetuximab and panitumumab are two distinct monoclonal antibodies (mAbs) targeting the epidermal growth factor receptor (EGFR), and both are widely used in combination with chemotherapy or as monotherapy to treat patients with RAS wild-type metastatic ...
Aderka, Dan, García Foncillas, Jesús, Ronga, Philippe, Stintzing, Sebastian, Sunakawa, Yu, Wainberg, Zev, Witzler, Pauline   +6 more
core   +1 more source

Antibodies to watch in 2020

mAbs, 2019
This 2020 installment of the annual ‘Antibodies to Watch’ series documents the antibody therapeutics approved in 2019 and in regulatory review in the United States or European Union, as well as those in late-stage clinical studies, as of November 2019 ...
H. Kaplon, Mrinalini Muralidharan, Zita Schneider, J. Reichert   +3 more
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

CD47 as a Potential Target to Therapy for Infectious Diseases

Antibodies, 2020
The integrin associated protein (CD47) is a widely and moderately expressed glycoprotein in all healthy cells. Cancer cells are known to induce increased CD47 expression.
Lamin B. Cham, Tom Adomati, Fanghui Li, Murtaza Ali, Karl S. Lang   +4 more
doaj   +1 more source

Specific detection of dengue and Zika virus antibodies using envelope proteins with mutations in the conserved fusion loop [PDF]

, 2017
Detection of antibodies is widely used for the diagnosis of infections with arthropod-borne flaviviruses including dengue (DENV) and Zika virus (ZIKV). Due to the emergence of ZIKV in areas endemic for DENV, massive co-circulation is observed and methods
Barzon, Luisa, Brites, Carlos, Drexler, Jan Felix, Ferreira, Orlando C, Kumbukgolla, Widuranga, Moges, Beyene, Moreira-Soto, Andres, Pal\uf9, Giorgio, Rockstroh, Alexandra, Sarno, Manoel, Schmidt-Chanasit, Jonas, Sinigaglia, Alessandro, Ulbert, Sebastian   +12 more
core   +2 more sources