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Different effector cell types in antibody-dependent cell-mediated cytotoxicity
Nature, 1975ANTIBODY-DEPENDENT cell-mediated cytotoxicity has been demonstrated in vitro using a number of continuously cultivated cell lines1,2 and nucleated erythrocytes3 as targets. Although the biological role of this cytotoxicity is not yet clear, it represents a potentially efficient cytotoxic mechanism and considerable interest has been shown in the ...
C J, Sanderson, I A, Clark, G A, Taylor
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Antibody-dependent cell-mediated cytotoxicity for cultured autologous melanoma cells
Cellular Immunology, 1981Abstract Sera from 33 patients with malignant melanoma were tested for antibody-dependent cellmediated cytotoxicity (ADCC) against cultured autologous melanoma cells prelabeled with [ 3 H]proline in a 36-h assay. Effector cells (autologous or from normal donors) were obtained by Ficoll-Hypaque separation of peripheral blood.
P O, Livingston +4 more
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Antibody-Dependent Lymphoid Cell-Mediated Cytotoxicity: Role of Complement
The Journal of Immunology, 1974Abstract Unsensitized lymphoid cells have the capacity to destroy antibody-coated target cells in vitro. Definitive studies to rule out the participation of complement (C) components in this reaction require a system with a complete absence of C components and with no possibility of endogenous synthesis of C by cells in culture.
J A, Van Boxel +3 more
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Influence of Hydrocortisone on Antibody-Dependent Lymphoid Cell Mediated Cytotoxicity
Immunological Communications, 1974Mice spleen lymphocytes which can be stimulated non-specifically by B cell mitogens such as lipopoly-saccharides (LPS) or a Nocardia water soluble mitogen (NWSM) are sensitive to cortisone. Experiments were performed in view of evaluating the influence of hydrocortisone on the lymphocyte-dependent antibody (LDA) cytotoxicity of mice spleen cells.
L, Chedid, D, Juy, C, Bona
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Antibody-dependent cell-mediated cytotoxicity (ADCC) in Aujeszky's disease
Archives of Virology, 1979Antibody-dependent cell-mediated cytotoxicity (ADCC) was studied using as targets 51Cr-labelled Vero cells infected with the Bartha strain of Aujeszky's disease virus (ADV). Using hyperimmune anti-ADV serum to sensitize the targets, porcine leukocytes from dextran-sedimented blood were found to be efficient effector cells yielding maximal 51Cr release ...
L A, Ashworth, G, Lloyd, A, Baskerville
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Methods for Measuring Antibody-Dependent Cell-Mediated Cytotoxicity In Vitro
2014Antibody-dependent cell-mediated cytotoxicity (ADCC) is a relevant characteristic to measure for a number of therapeutic monoclonal antibodies (mAbs) under development. ADCC is a mechanism by which antibody-opsonized, infected, or cancerous cells are destroyed by FcγRIII (CD16)-expressing effector cells.
Aaron S, Miller +2 more
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Antibody-dependent cell-mediated cytotoxicity
Survey of Immunologic Research, 1983E W, Fuson +5 more
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Antibody-Dependent Cell-Mediated Cytotoxicity
Gastroenterology, 1976Martin F. Kagnoff, Stephen Campbell
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