Results 191 to 200 of about 316,215 (308)

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

TNF-α and IFN-γ differentially regulate AML cell susceptibility to CD70-antibody-mediated cytotoxicity. [PDF]

J Immunother Cancer
Sponheimer M, White K, Ulrich M, Kazerani M, Maiser A, Tyborski ET, Rappa GP, Richter D, Briem E, Hänel G, Philipp N, Nixdorf D, Rohrbacher L, Marcinek A, Linder A, Kuhl N, Piseddu I, Straub T, Harz H, Wichmann C, Maenner D, Rudelius M, Hornung V, Leonhardt H, Van Elssen CHMJ, Abdelhamed S, Diolaiti D, Bücklein V, Subklewe M.   +28 more
europepmc   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Few‐Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell‐Like Phenotypes

Advanced Healthcare Materials, EarlyView.
Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar, Peifu Cheng, Tugce Dogruel, Maxsam Donta, Juhyung Jung, Naomi A. Asante, Donald S. Sakaguchi, Surya K. Mallapragada, Piran R. Kidambi, Metin Uz   +9 more
wiley   +1 more source

IgE based therapeutics are an emerging modality in cancer treatment. [PDF]

Discov Oncol
Kumari S, Ghosh S, Doerner A.
europepmc   +1 more source

The in vivo effect of hepatotrophic factors ALR, HGF, and IGF-II on natural killer cell functions [PDF]

, 1997
Azzarone, A, Deleo, A, Francavilla, A, Hagiya, M, Iacobellis, A, Polimeno, L, Starzl, TE, Vujanovic, N, Whiteside, T   +8 more
core  

Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash, Jacob Robins, J. Scott VanEpps, Minji Kim, Jouha Min   +4 more
wiley   +1 more source

562 SO-C101 induces NK cell cytotoxicity and potentiates antibody-dependent cell cytotoxicity and anti-tumor activity

Journal for ImmunoTherapy of Cancer, 2020
Zuzana Antosova, Marketa Jiratova, Eva Nedvedova   +2 more
doaj   +1 more source

Unraveling the dual roles of tumor-infiltrating antibodies in solid tumors: friend or foe in the tumor microenvironment? [PDF]

Front Immunol
Miao L, Zhou R, Zhang L, Feng L, Wang Y, Song P, Lv D, Shen TM.   +7 more
europepmc   +1 more source

Metallofullerenol Sc3N@C80(OH)18: A New Generation Radioprotector Protecting Human Erythrocytes Against Multiple Biochemical Damage Modes Upon Gamma Irradiation, Identifying It as a Scavenger of Short‐ and Long‐Lived Radicals

Advanced Healthcare Materials, EarlyView.
Metallofullerenol Sc3N@C80(OH)18 demonstrates strong radioprotective properties as a scavenger of both short‐ and long‐lived radicals. The study reveals protection of human erythrocytes from γ‐radiation–induced biochemical damage via post‐irradiation removal of primary and secondary reactive oxidants, supported by pulse radiolysis kinetics.
Jacek Grebowski, Maciej Studzian, Szymon Lekki‐Porebski, Anna Konarska, Marian Wolszczak, Grzegorz Litwinienko, Lukasz Pulaski   +6 more
wiley   +1 more source