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Bovine antibody dependent cell-mediated cytotoxicity (ADCC) effector cells

Veterinary Immunology and Immunopathology, 1987
ADCC effector cells from bovine blood were separated by centrifugation, adherence and rosetting techniques. Each enriched cell population, peripheral blood mononuclear cells (PBM), null lymphocytes, monocytes and neutrophils, was then examined for its capacity to mediate ADCC.
E L, Belden, H M, Peng
openaire   +2 more sources

Assessing Antibody-dependent, Cell-mediated Cytotoxicity in Cancer Cells using Antibody-Dependent Cell-Mediated Cytotoxicity Reporter Bioassay

Journal of Visualized Experiments
The method for antibody-dependent, cell-mediated cytotoxicity (ADCC) represents an important tool to assess the efficacy of therapeutic antibodies in cancer immunotherapy. Evaluating ADCC activity in cancer cells is essential for the development and optimization of antibody-based treatments.
Kelvin Kam Yew, Kuan   +4 more
openaire   +2 more sources

SELECTIVE REACTIONS IN ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY

Transplantation, 1977
Selective reactions associated with HLA specificity were sought in antibody-dependent cell-mediated cytotoxic tests against HLA-typed lymphoblastoid lines using operationally monospecific HLA sera and effector cells from healthy individuals. Precise detection of HLA specificities was disturbed by the presence of natural antibodies in HLA antiserum and ...
J, Takasugi, M, Takasugi
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Reversible blocking of antibody-dependent cell-mediated cytotoxicity

Cellular Immunology, 1977
Abstract The ability of human peripheral blood lymphocytes to kill antibody-coated Chang liver cells in antibody-dependent cell-mediated cytotoxicity (ADCC) can be blocked with aggregated IgG (agg-IgG) or by soluble immune complexes. Dissociation of aggregates of IgG or immune complexes from the cell surface, however, resulted in partial recovery of ...
K, Sugamura, J B, Smith
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Antibody-Dependent Cell-Mediated Cytotoxicity in Humans

The Journal of Immunology, 1975
Abstract Mononuclear cells from human peripheral blood are able to destroy alloantibody-coated target cells of a human lymphoblastoid line. The effector cell is a nonadherent, non-phagocytic, medium sized lymphoid cell. This cell is not detectable in early human fetuses.
Giorgio Trinchieri   +3 more
openaire   +2 more sources

Antibody-Dependent Cell-Mediated Cytotoxicity Against Influenza Virus-Infected Cells

Journal of Infectious Diseases, 1983
The three major immunocompetent cells in human peripheral blood (lymphocytes, neutrophils, and monocytes) were shown to be effector cells for antibody-dependent cell-mediated cytotoxicity (ADCC) against influenza virus-infected baby hamster kidney cells in vitro.
G, Hashimoto, P F, Wright, D T, Karzon
openaire   +2 more sources

Antibody-dependent cell-mediated cytotoxicity for cultured autologous melanoma cells

Cellular Immunology, 1981
Abstract Sera from 33 patients with malignant melanoma were tested for antibody-dependent cellmediated cytotoxicity (ADCC) against cultured autologous melanoma cells prelabeled with [ 3 H]proline in a 36-h assay. Effector cells (autologous or from normal donors) were obtained by Ficoll-Hypaque separation of peripheral blood.
P O, Livingston   +4 more
openaire   +2 more sources

Antibody‐dependent cell cytotoxicity: immunotherapy strategies enhancing effector NK cells

Immunology & Cell Biology, 2017
Antibody‐dependent cellular cytotoxicity (ADCC) is a set of mechanisms that target cells coated with IgG antibodies of the proper subclasses (IgG1 in the human) to be the prey of cell‐to‐cell cytolysis executed by immune cells expressing FcRIIIA (CD16A).
Maria Carmen, Ochoa   +7 more
openaire   +2 more sources

Different effector cell types in antibody-dependent cell-mediated cytotoxicity

Nature, 1975
ANTIBODY-DEPENDENT cell-mediated cytotoxicity has been demonstrated in vitro using a number of continuously cultivated cell lines1,2 and nucleated erythrocytes3 as targets. Although the biological role of this cytotoxicity is not yet clear, it represents a potentially efficient cytotoxic mechanism and considerable interest has been shown in the ...
C J, Sanderson, I A, Clark, G A, Taylor
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Antibody-dependent cell-mediated cytotoxicity (ADCC) in Aujeszky's disease

Archives of Virology, 1979
Antibody-dependent cell-mediated cytotoxicity (ADCC) was studied using as targets 51Cr-labelled Vero cells infected with the Bartha strain of Aujeszky's disease virus (ADV). Using hyperimmune anti-ADV serum to sensitize the targets, porcine leukocytes from dextran-sedimented blood were found to be efficient effector cells yielding maximal 51Cr release ...
L A, Ashworth, G, Lloyd, A, Baskerville
openaire   +2 more sources

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