Results 221 to 230 of about 1,768,583 (320)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

The impact of vaccine booster doses on specific B- and T-lymphocyte dynamics in Thai healthcare personnel following COVID-19 vaccination. [PDF]

Sci Rep
Kittikraisak W, Leepiyasakulchai C, Saelee C, Tanathitikorn C, Suttha P, Punjasamanvong S, Piyaraj P, Wongrapee T, Yoocharoen P, Chottanapund S, Mott JA.   +10 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

The combination of anti-PD-1 antibodies, trastuzumab and chemotherapy may improve the outcome of some patients with HER2-positive alpha-fetoprotein-producing gastric cancer: a retrospective real-world analysis from a single center. [PDF]

BMC Cancer
Ge S, Wang F, Li H, Yang Y, Zhang L, Duan J, Bai M, Liu R, Ning T, Wang X, Ji Z, Sun Y, Deng T.   +12 more
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

IL-17⁺/IL-10⁺ Ratio in TCRαβ⁺ CD4^- CD8^- T Cells As a Marker of Disease Activity in Lupus-Prone Mice and Patients With Systemic Lupus Erythematosus. [PDF]

ACR Open Rheumatol
Imai R, Li Y, Li H, Kar A, Fu R, Li W, Kyttaris VC, Tsokos GC.   +7 more
europepmc   +1 more source

DIRECT EVIDENCE THAT B-1 LIKE LYMPHOCYTES PRODUCE XENOREACTIVE ANTIBODIES USING SINGLE-CELL ANALYSIS

, 1998
Shigeki Wakiyama, Joyce Swensson, Guo‐Du Wu, Eiji Gochi, Robert Mendez, Donald V. Cramer   +5 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Genetic Divergence and Antibody Expression Influence the N-Glycomes of CHO-K1 and CHO-S Cells. [PDF]

Biotechnol Bioeng
Donini R, Blundell P, Pleass RJ, Lu D, Dell A, Kontoravdi C, Haslam SM.   +6 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source