Results 241 to 250 of about 556,937 (315)

COX-2 regulates IL-17A-producing γδ T cells to drive mismatch repair-deficient colon cancer

Suzuki T, White M, Leach J, Edwards J, Gilroy K, Porter R, Hong Y, Terradas-Terradas M, Hayman H, Mohamed NE, Lannagan T, Mackey J, Ridgway R, Campbell A, Verbandt S, Kirschner K, Tejpar S, Edwards J, Dunne P, Coffelt S, Sansom O.   +20 more
europepmc   +1 more source

In vivo production of an anti-HIV antibody in mice by non-viral gene knockin in primate hematopoietic stem and progenitor cells. [PDF]

Mol Ther
Castelli JMP, Poljakov K, Jwa Y, Cunningham R, Cassidy ME, Gray MD, Sanchez Gaytan JN, Enstrom MR, Gastelum G, Wang Z, Linton JD, Rongvaux A, Taylor JJ, Adair JE.   +13 more
europepmc   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Not all plasma cells are made equal: well-hidden layers of heterogeneity. [PDF]

Front Immunol
Akessé AA, Bonaud A.
europepmc   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Re-shaping the immune response to influenza vaccination in a host with immune memory from influenza infection. [PDF]

NPJ Vaccines
White CL, Mengu L, Sidhu IS, Gandhapudi SK, Richards KA, Sant AJ.   +5 more
europepmc   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Humoral and cellular immune response after COVID-19 vaccination in patients with sickle cell disease on hydroxyurea. [PDF]

Blood Adv
Haggenburg S, Pothast CR, Hofsink Q, Haverkate NJE, Bhoekhan MS, Claireaux M, van Binnendijk RS, Hartog GD, Lissenberg-Witte BI, de Vries RD, van Tuijn C, Biemond BJ, Nur E, Geurts van Kessel CH, Mutsaers PGNJ, Broers AEC, Goorhuis A, Nijhof IS, van Gils MJ, Heemskerk MHM, Hazenberg MD, Rutten CE, van Meerloo JJH, Smit GP, Wouters D, van Leeuwen EMM, Bontkes HJ, Kootstra N, Kant IMJ, Graas T, Toussaint B, de Jong S, Darwesh S, Mahes SS, Kamminga D, Koelewijn M, Faber G, Beaumont G, Engel MD, Pierie RCN, Janssen SR, Faber G, Groen K, Burger JA, Bouhuijs JH, Baars PA, van Dijkman E, Heijmans J, Witte YY, Nahui Palomino RA, Omar SZ, Zweegman S, Kater AP, van den Vegt C, Arends-Halbesma I, de Pater E, Dijkstra MJ, van Beek J, Rots NY, Rijnstra ES, de Rooij DM, Sanders RW, Poniman M, Olijhoek W, van Rijswijk J, Beaumont T, Çetinel L, Schellekens L, den Hartogh YM, Cloos J, Weijers SS, Tonouh-Aajoud S, Avci S, Roelandse-Koop E, Dik WA, Vogels-Nooijen S.   +75 more
europepmc   +1 more source

Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats

Advanced Functional Materials, EarlyView.
We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang, Ilya Pyatnitskiy, Yanshu Shi, Kai Wing Kevin Tang, Yi Xie, Sihan Yu, Thomas Wynn, Xiangping Liu, Ju‐Chun Hsieh, Jinmo Jeong, Weilong He, Brinkley Artman, Anakaren Romero Lozano, Xi Shi, Arjun Sangani, Lief E Fenno, Samantha Santacruz, Banglin Chen, Huiliang Wang   +18 more
wiley   +1 more source