Results 101 to 110 of about 5,125,209 (406)

A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Nature Communications, 2020
Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time.
A. Huang, Bernardo García-Carreras, M. Hitchings, Bingyi Yang, L. Katzelnick, S. Rattigan, Brooke A. Borgert, Carlos A Moreno, B. Solomon, L. Trimmer-Smith, Veronique Etienne, I. Rodríguez-Barraquer, J. Lessler, Henrik Salje, D. Burke, A. Wesolowski, D. Cummings   +16 more
semanticscholar   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities

mAbs, 2022
Controlled Fab arm exchange (cFAE) has proven to be a generic and versatile technology for the efficient generation of IgG-like bispecific antibodies (DuoBodies or DBs), with several in clinical development and one product, amivantamab, approved by the ...
Desislava Yanakieva, Lukas Pekar, Andreas Evers, Markus Fleischer, Stephan Keller, Dirk Mueller-Pompalla, Lars Toleikis, Harald Kolmar, Stefan Zielonka, Simon Krah   +9 more
doaj   +1 more source

Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis. [PDF]

, 2016
The invasion-promoting MT1-MMP is a cell surface-associated collagenase with a plethora of critical cellular functions. There is a consensus that MT1-MMP is a key protease in aberrant pericellular proteolysis in migrating cancer cells and, accordingly, a
Cieplak, Piotr, Ge, Xin, Nam, Dong Hyun, Remacle, Albert G, Shiryaev, Sergey A, Strongin, Alex Y   +5 more
core   +1 more source

Antibody-Mediated Encephalitis.

New England Journal of Medicine, 2018
Antibody-Mediated Encephalitis The category of autoimmune encephalitides constitutes disorders with relatively distinct characteristics such as psychosis, seizures, abnormal movements, coma, and dysautonomia.
J. Dalmau, F. Graus
semanticscholar   +1 more source

Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients

Science immunology, 2020
Saliva is an alternative biofluid to serum for detecting and monitoring IgG to SARS-CoV-2 spike and RBD antigens in COVID-19. While the antibody response to SARS-CoV-2 has been extensively studied in blood, relatively little is known about the antibody ...
B. Isho, K. Abe, Michelle Zuo, Alainna J. Jamal, B. Rathod, Jenny H. Wang, Zhijie Li, G. Chao, Olga L. Rojas, Yeo Myong Bang, A. Pu, Natasha Christie-Holmes, C. Gervais, D. Ceccarelli, Payman Samavarchi-Tehrani, Furkan Guvenc, P. Budylowski, A. Li, A. Paterson, F. Yue, L. M. Marin, L. Caldwell, J. Wrana, K. Colwill, F. Sicheri, S. Mubareka, S. Gray-Owen, S. Drews, W. Siqueira, M. Barrios-Rodiles, M. Ostrowski, J. Rini, Y. Durocher, A. McGeer, J. Gommerman, A. Gingras   +35 more
semanticscholar   +1 more source

The cytochrome oxidase defect in ISC‐depleted yeast is caused by impaired iron–sulfur cluster maturation of the mitoribosome assembly factor Rsm22

FEBS Letters, EarlyView.
The yeast mitoribosome assembly factor Rsm22 contains a [4Fe‐4S] cluster that is matured by the mitochondrial iron–sulfur cluster assembly (ISC) machinery. Defects in ISC components result in impaired mitochondrial protein synthesis due to a mitoribosome assembly defect.
Ulrich Mühlenhoff, Dominik Trauth, Weronika Śliwińska, Linda Boss, Roland Lill   +4 more
wiley   +1 more source

SARS CoV subunit vaccine: Antibodymediated neutralisation and enhancement [PDF]

, 2012
1. A SARS vaccine was produced based on recombinant native full-length Spike-protein trimers (triSpike) and efficient establishment of a vaccination procedure in rodents. 2.
Altmeyer, R, Bruzzone, R, Cheung, CY, Daeron, M, Dutry, I, Escriou, N, Jaume, M, Kam, YW, Kien, F, Li, PH, Nal, B, Peiris, JSM, Roberts, A, Subbarao, K, Yip, MS   +14 more
core   +1 more source

Rubisco : easy purification and immunochemical determination [PDF]

, 2001
Rubisco (Ribulose-1.5-bisphosphate carboxylase/oxygenase) from spinach was purified to homogeneity in one step by gel filtration. This enzyme is suitable for the generation of a specific antibody in rabbits.
Groß, Ulrich
core   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source